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Identification
NameColchicine
Accession NumberDB01394
TypeSmall Molecule
GroupsApproved
DescriptionA major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]
Structure
Thumb
Synonyms
Colchicin
Colchicina
Colchicinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Colchicinetablet1 mgoralEuro Pharm International Canada Inc1950-12-312012-06-14Canada
Colchicinecapsule.6 mg/1oralWest ward Pharmaceutical Corp2014-10-01Not applicableUs
Colchicinetablet0.6 mgoralSandoz Canada Incorporated1974-12-31Not applicableCanada
Colchicinetablet, film coated.6 mg/1oralPrasco Laboratories2015-01-12Not applicableUs
Colchicine Tab 0.6mgtablet0.6 mgoralOdan Laboratories Ltd1982-12-31Not applicableCanada
Colchicine Tab 0.6mgtablet0.6 mgoralD.C. Labs Limited1969-12-312003-07-11Canada
Colchicine Tab 0.6mgtablet0.6 mgoralAbbott Laboratories, Limited1951-12-312007-07-31Canada
Colchicine Tab 1mgtablet1 mgoralOdan Laboratories Ltd1985-12-312013-03-06Canada
Colcrystablet, film coated.6 mg/1oralREMEDYREPACK INC.2013-05-032016-04-05Us
Colcrystablet, film coated.6 mg/1oralAvera Mc Kennan Hospital2015-08-05Not applicableUs
Colcrystablet, film coated.6 mg/1oralProficient Rx LP2009-09-01Not applicableUs
Colcrystablet, film coated.6 mg/1oralAR Scientific Inc.2009-09-01Not applicableUs
Colcrystablet, film coated.6 mg/1oralPhysicians Total Care, Inc.2011-10-19Not applicableUs
Colcrystablet, film coated.6 mg/1oralTakeda Pharmaceuticals America, Inc.2009-09-01Not applicableUs
Colcrystablet, film coated.6 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-09-01Not applicableUs
Colcrystablet, film coated.6 mg/1oralCardinal Health2009-09-01Not applicableUs
Colcrystablet, film coated.6 mg/1oralREMEDYREPACK INC.2013-02-212016-04-05Us
Euro-colchicinetablet0.6 mgoralEuro Pharm International Canada IncNot applicableNot applicableCanada
Jamp-colchicinetablet0.6 mgoralJamp Pharma Corporation2011-10-07Not applicableCanada
Jamp-colchicinetablet1.0 mgoralJamp Pharma Corporation2011-10-072013-04-03Canada
Mitigarecapsule.6 mg/1oralHikma Americas, Inc.2014-10-01Not applicableUs
PMS-colchicinetablet0.6 mgoralPharmascience Inc2013-02-27Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Probenecid and ColchicineWatson Laboratories, Inc.
Verban OntWelcker Lyster Ltd., Division Of Technilab Inc.
SaltsNot Available
Categories
UNIISML2Y3J35T
CAS number64-86-8
WeightAverage: 399.437
Monoisotopic: 399.168187537
Chemical FormulaC22H25NO6
InChI KeyInChIKey=IAKHMKGGTNLKSZ-UHFFFAOYSA-N
InChI
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
IUPAC Name
N-{3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0²,⁷]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide
SMILES
COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1C(CC2)NC(C)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tropones. These are compounds containing a tropone ring, which is a cycloheptatrienone ring bearing a ketone group.
KingdomOrganic compounds
Super ClassHydrocarbon derivatives
ClassTropones
Sub ClassNot Available
Direct ParentTropones
Alternative Parents
Substituents
  • Tropone
  • Anisole
  • Alkyl aryl ether
  • Benzenoid
  • Acetamide
  • Cyclic ketone
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Ether
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor treatment and relief of pain in attacks of acute gouty arthritis.
PharmacodynamicsColchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition.
Mechanism of actionThe precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack. Colchicine decreases leukocyte chemotaxis and phagocytosis and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Colchicine has no analgesic or antihyperuricemic activity. Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit tubulin. Although some studies have found that this action probably does not contribute significantly to colchicine's antigout action, a recent in vitro study has shown that it may be at least partially involved.
Related Articles
AbsorptionColchicine is rapidly absorbed after oral administration, probably from the jejunum and ileum. However, the rate and extent of absorption are variable, depending on the tablet dissolution rate; variability in gastric emptying, intestinal motility, and pH at the absorption site; and the extent to which colchicine is bound to microtubules in gastrointestinal mucosal cells.
Volume of distribution
  • 5 to 8 L/kg [healthy young volunteers]
Protein bindingLow to moderate (30 to 50%).
Metabolism

Probably hepatic. Although colchicine metabolites have not been identified in humans, metabolism by mammalian hepatic microsomes has been demonstrated in vitro.

Route of eliminationIn healthy volunteers (n=12) 40 – 65% of 1 mg orally administered colchicine was recovered unchanged in urine. Enterohepatic recirculation and biliary excretion are also postulated to play a role in colchicine elimination.
Half lifeElimination half-life is approximately 1 hour in healthy subjects, although a study with an extended sampling time reported mean terminal elimination half-life values of approximately 9 to 10.5 hours. Other studies have reported half-life values of approximately 2 hours in patients with alcoholic cirrhosis and approximately 2.5 hours in patients with familial Mediterranean fever.
Clearance
  • 0.17 L/hr/kg [familial Mediterranean fever patients with end-stage renal disease]
  • 0.73 L/hr/kg [familial Mediterranean fever patients with normal renal function]
ToxicityThe onset of toxic effects is usually delayed for several hours or more after the ingestion of an acute overdose. Nausea, vomiting, abdominal pain, and diarrhea occur first. The diarrhea may be bloody due to hemorrhagic gastroenteritis. Burning sensations of the throat, stomach, and skin may be prominent symptoms. Extensive vascular damage may result in shock. Kidney damage, evidenced by hematuria and oliguria, may occur. Muscular weakness may be marked, and ascending paralysis of the central nervous system may develop; the patient usually remains conscious. Delirium and convulsions may occur. Death due to respiratory arrest may result. Although death from the ingestion of as little as 7 mg has been reported, much larger doses have been survived .
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9856
Blood Brain Barrier+0.7865
Caco-2 permeable+0.5119
P-glycoprotein substrateNon-substrate0.594
P-glycoprotein inhibitor INon-inhibitor0.8007
P-glycoprotein inhibitor IINon-inhibitor0.6956
Renal organic cation transporterNon-inhibitor0.8997
CYP450 2C9 substrateNon-substrate0.8042
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7359
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7959
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9208
BiodegradationReady biodegradable0.6489
Rat acute toxicity2.3748 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9877
hERG inhibition (predictor II)Non-inhibitor0.7394
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Capsuleoral.6 mg/1
Tabletoral1 mg
Tabletoral0.6 mg
Tablet, film coatedoral.6 mg/1
Tabletoral1.0 mg
Tabletoral
Ointmenttopical
Prices
Unit descriptionCostUnit
Colchicine powder306.6USD g
Colcrys 0.6 mg tablet5.82USD tablet
Colchicine 0.6 mg tablet0.58USD tablet
Colchicine 1 mg Tablet0.55USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7601758 No2009-02-102029-02-10Us
US7619004 No2008-12-032028-12-03Us
US7820681 No2009-02-172029-02-17Us
US7906519 No2009-02-172029-02-17Us
US7915269 No2009-02-172029-02-17Us
US7935731 No2008-12-032028-12-03Us
US7964647 No2008-10-062028-10-06Us
US7964648 No2008-10-062028-10-06Us
US7981938 No2008-10-062028-10-06Us
US8093296 No2008-10-062028-10-06Us
US8093297 No2008-10-062028-10-06Us
US8093298 No2008-10-062028-10-06Us
US8097655 No2008-10-062028-10-06Us
US8415395 No2008-10-062028-10-06Us
US8415396 No2008-10-062028-10-06Us
US8440721 No2009-02-172029-02-17Us
US8440722 No2009-02-172029-02-17Us
US8927607 No2013-08-222033-08-22Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point156 °CPhysProp
water solubility4.5E+004 mg/L (at 25 °C)SEIDELL,A (1941)
logP1.30HANSCH,C ET AL. (1995)
pKa1.85SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0276 mg/mLALOGPS
logP1.59ALOGPS
logP1.46ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)15.06ChemAxon
pKa (Strongest Basic)-0.038ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area83.09 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity111.38 m3·mol-1ChemAxon
Polarizability42.41 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Christian Wehrey, “Colchicine derivatives, process for preparing them, products obtained therefrom and use thereof.” U.S. Patent US20040138182, issued July 15, 2004.

US20040138182
General ReferencesNot Available
External Links
ATC CodesM04AC01
AHFS Codes
  • 92:00.00
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.9 KB)
Interactions
Drug Interactions
Drug
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Colchicine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Colchicine.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Colchicine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Colchicine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Colchicine.
AlbendazoleThe serum concentration of Colchicine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Colchicine can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Colchicine.
AlectinibThe serum concentration of Colchicine can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Colchicine can be increased when it is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Colchicine.
AmantadineThe serum concentration of Colchicine can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Colchicine.
Aminohippuric acidThe serum concentration of Colchicine can be increased when it is combined with Aminohippuric acid.
AmiodaroneThe serum concentration of Colchicine can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Colchicine.
AmlodipineThe serum concentration of Colchicine can be increased when it is combined with Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Colchicine.
AmprenavirThe serum concentration of Colchicine can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Colchicine can be increased when it is combined with Amsacrine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Colchicine.
AprepitantThe serum concentration of Colchicine can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Colchicine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Colchicine.
AstemizoleThe serum concentration of Colchicine can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Colchicine.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Colchicine.
AtomoxetineThe metabolism of Colchicine can be decreased when combined with Atomoxetine.
AtorvastatinColchicine may increase the myopathic rhabdomyolysis activities of Atorvastatin.
AtorvastatinThe serum concentration of Colchicine can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Colchicine.
AzelastineThe serum concentration of Colchicine can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Colchicine can be increased when it is combined with Azithromycin.
BenzocaineThe serum concentration of Colchicine can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Colchicine can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Colchicine.
BevacizumabBevacizumab may increase the cardiotoxic activities of Colchicine.
BexaroteneThe serum concentration of Colchicine can be decreased when it is combined with Bexarotene.
BezafibrateBezafibrate may increase the myopathic rhabdomyolysis activities of Colchicine.
BiperidenThe serum concentration of Colchicine can be increased when it is combined with Biperiden.
BoceprevirThe serum concentration of Colchicine can be increased when it is combined with Boceprevir.
BortezomibThe metabolism of Colchicine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Colchicine can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Colchicine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Colchicine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Colchicine.
BuprenorphineThe serum concentration of Colchicine can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Colchicine can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Colchicine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Colchicine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Colchicine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Colchicine.
CandesartanThe serum concentration of Colchicine can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Colchicine can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Colchicine can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Colchicine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Colchicine.
CarvedilolThe serum concentration of Colchicine can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Colchicine can be increased when it is combined with Caspofungin.
CeritinibThe serum concentration of Colchicine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Colchicine.
ChloroquineThe serum concentration of Colchicine can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Colchicine.
ChlorpropamideThe serum concentration of Colchicine can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Colchicine can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Colchicine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Colchicine can be decreased when it is combined with Cholic Acid.
Choline C 11The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.
CilazaprilThe serum concentration of Colchicine can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Colchicine can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Colchicine.
CiprofibrateCiprofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Colchicine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Colchicine.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Colchicine.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Colchicine.
ClemastineThe metabolism of Colchicine can be decreased when combined with Clemastine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Colchicine.
ClofazimineThe serum concentration of Colchicine can be increased when it is combined with Clofazimine.
ClofibrateClofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Colchicine.
ClomipramineThe serum concentration of Colchicine can be increased when it is combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Colchicine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Colchicine.
ClotrimazoleThe metabolism of Colchicine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Colchicine.
CobicistatThe serum concentration of Colchicine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Colchicine.
Coenzyme Q10Colchicine may increase the myopathic rhabdomyolysis activities of Coenzyme Q10.
ColforsinThe serum concentration of Colchicine can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Colchicine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Colchicine.
CrizotinibThe metabolism of Colchicine can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Colchicine.
CyanocobalaminThe serum concentration of Cyanocobalamin can be decreased when it is combined with Colchicine.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Colchicine.
CyclosporineThe metabolism of Colchicine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Colchicine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Colchicine.
DabrafenibThe serum concentration of Colchicine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Colchicine.
DaclatasvirThe serum concentration of Colchicine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Colchicine.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Colchicine.
DarunavirThe serum concentration of Colchicine can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Colchicine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Colchicine can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Colchicine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Colchicine.
DeferasiroxThe serum concentration of Colchicine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Colchicine can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Colchicine can be increased when it is combined with Desipramine.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Colchicine.
DesloratadineThe serum concentration of Colchicine can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Colchicine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Colchicine.
DextromethorphanThe serum concentration of Colchicine can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Colchicine.
DiclofenacThe serum concentration of Colchicine can be increased when it is combined with Diclofenac.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Colchicine.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Colchicine.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Colchicine.
DigoxinThe serum concentration of Colchicine can be increased when it is combined with Digoxin.
DihydroergotamineThe metabolism of Colchicine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Colchicine.
DiltiazemThe metabolism of Colchicine can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Colchicine.
DipyridamoleThe serum concentration of Colchicine can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Colchicine.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Colchicine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Colchicine.
DoxazosinThe serum concentration of Colchicine can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Colchicine can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Colchicine can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Colchicine.
DoxycyclineThe metabolism of Colchicine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Colchicine can be increased when it is combined with Dronabinol.
DronedaroneThe metabolism of Colchicine can be decreased when combined with Dronedarone.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Colchicine.
EfavirenzThe serum concentration of Colchicine can be decreased when it is combined with Efavirenz.
ElbasvirThe serum concentration of Colchicine can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Colchicine.
EnalaprilThe serum concentration of Colchicine can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Colchicine can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Colchicine.
ErgonovineThe serum concentration of Colchicine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Colchicine can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Colchicine.
ErythromycinThe metabolism of Colchicine can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Colchicine.
Eslicarbazepine acetateThe serum concentration of Colchicine can be decreased when it is combined with Eslicarbazepine acetate.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Colchicine.
EstramustineThe serum concentration of Colchicine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Colchicine can be decreased when it is combined with Estriol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Colchicine.
EstroneThe serum concentration of Colchicine can be decreased when it is combined with Estrone.
EstroneThe serum concentration of Estrone can be increased when it is combined with Colchicine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Colchicine.
EtofibrateEtofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.
EtoposideThe serum concentration of Colchicine can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Colchicine can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Colchicine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Colchicine.
FelodipineThe serum concentration of Colchicine can be increased when it is combined with Felodipine.
FenofibrateFenofibrate may increase the myopathic rhabdomyolysis activities of Colchicine.
FentanylThe serum concentration of Colchicine can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Colchicine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Colchicine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Colchicine.
FluconazoleThe metabolism of Colchicine can be decreased when combined with Fluconazole.
FluoxetineThe serum concentration of Colchicine can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Colchicine can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Colchicine can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Colchicine can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Colchicine.
FluvastatinColchicine may increase the myopathic rhabdomyolysis activities of Fluvastatin.
FluvoxamineThe metabolism of Colchicine can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Colchicine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Colchicine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Colchicine can be increased when combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Colchicine can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Colchicine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Colchicine.
GemfibrozilGemfibrozil may increase the myopathic rhabdomyolysis activities of Colchicine.
GenisteinThe serum concentration of Colchicine can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Colchicine can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Colchicine can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Colchicine can be increased when it is combined with Gramicidin D.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Colchicine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Colchicine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Colchicine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Colchicine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Colchicine.
IdelalisibThe serum concentration of Colchicine can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Colchicine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Colchicine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Colchicine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Colchicine.
IndinavirThe serum concentration of Colchicine can be decreased when it is combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Colchicine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Colchicine.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Colchicine.
IsavuconazoniumThe metabolism of Colchicine can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Colchicine can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Colchicine can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Colchicine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Colchicine.
KetamineThe serum concentration of Colchicine can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Colchicine.
KetoconazoleThe serum concentration of Colchicine can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Colchicine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Colchicine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Colchicine.
LapatinibThe serum concentration of Colchicine can be increased when it is combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Colchicine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Colchicine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Colchicine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Colchicine.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Colchicine.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Colchicine.
LevothyroxineThe serum concentration of Colchicine can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Colchicine can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Colchicine.
LiothyronineThe serum concentration of Colchicine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Colchicine can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Colchicine can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Colchicine can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Colchicine.
LopinavirThe serum concentration of Colchicine can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Colchicine can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Losartan can be increased when it is combined with Colchicine.
LovastatinColchicine may increase the myopathic rhabdomyolysis activities of Lovastatin.
LovastatinThe metabolism of Colchicine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Colchicine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Colchicine can be decreased when it is combined with Lumacaftor.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Colchicine.
MaprotilineThe serum concentration of Colchicine can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Colchicine can be increased when it is combined with Mebendazole.
MefloquineThe serum concentration of Colchicine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Colchicine can be increased when it is combined with Megestrol acetate.
MeprobamateThe serum concentration of Colchicine can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Colchicine can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Colchicine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Colchicine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Colchicine.
MevastatinColchicine may increase the myopathic rhabdomyolysis activities of Mevastatin.
MibefradilThe serum concentration of Colchicine can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Colchicine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Colchicine can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Colchicine.
MifepristoneThe metabolism of Colchicine can be decreased when combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Colchicine.
MitomycinThe serum concentration of Colchicine can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Colchicine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Colchicine can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Colchicine.
ModafinilThe serum concentration of Colchicine can be decreased when it is combined with Modafinil.
MorphineThe serum concentration of Morphine can be increased when it is combined with Colchicine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Colchicine.
NadololThe serum concentration of Nadolol can be increased when it is combined with Colchicine.
NafcillinThe serum concentration of Colchicine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Colchicine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Colchicine.
NaltrexoneThe serum concentration of Colchicine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Colchicine can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Colchicine can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Colchicine can be decreased when it is combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Colchicine.
NeostigmineThe serum concentration of Colchicine can be increased when it is combined with Neostigmine.
NetupitantThe serum concentration of Colchicine can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Colchicine can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Colchicine can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Colchicine can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Colchicine.
NilotinibThe metabolism of Colchicine can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Colchicine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Colchicine.
NisoldipineThe serum concentration of Colchicine can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Colchicine can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Colchicine can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Colchicine.
NorethisteroneThe serum concentration of Colchicine can be decreased when it is combined with Norethisterone.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Colchicine.
OlaparibThe metabolism of Colchicine can be decreased when combined with Olaparib.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Colchicine.
OmeprazoleThe serum concentration of Colchicine can be increased when it is combined with Omeprazole.
OsimertinibThe serum concentration of Colchicine can be increased when it is combined with Osimertinib.
OuabainOuabain may decrease the cardiotoxic activities of Colchicine.
P-NitrophenolThe serum concentration of Colchicine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Colchicine can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Colchicine can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Colchicine can be increased when it is combined with Palmitic Acid.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Colchicine.
PantoprazoleThe serum concentration of Colchicine can be increased when it is combined with Pantoprazole.
ParoxetineThe serum concentration of Colchicine can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Colchicine.
PentobarbitalThe metabolism of Colchicine can be increased when combined with Pentobarbital.
PerindoprilThe serum concentration of Colchicine can be increased when it is combined with Perindopril.
PhenobarbitalThe serum concentration of Colchicine can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Colchicine.
PhenytoinThe metabolism of Colchicine can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Colchicine.
PimozideThe serum concentration of Colchicine can be increased when it is combined with Pimozide.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Colchicine.
Platelet Activating FactorThe serum concentration of Colchicine can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Colchicine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Colchicine.
PosaconazoleThe serum concentration of Colchicine can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Colchicine.
PrazosinThe serum concentration of Colchicine can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Colchicine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Colchicine.
PrimidoneThe metabolism of Colchicine can be increased when combined with Primidone.
ProbenecidThe serum concentration of Colchicine can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Colchicine can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Colchicine.
PromethazineThe serum concentration of Colchicine can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Colchicine can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Colchicine.
ProtriptylineThe serum concentration of Colchicine can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Colchicine.
QuercetinThe serum concentration of Colchicine can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Colchicine.
QuinacrineThe serum concentration of Colchicine can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Colchicine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Colchicine.
RanitidineThe serum concentration of Colchicine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Colchicine.
ReboxetineThe serum concentration of Colchicine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Colchicine can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Colchicine can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Colchicine.
RifabutinThe metabolism of Colchicine can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Colchicine can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Colchicine.
RifapentineThe metabolism of Colchicine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Colchicine.
RilpivirineThe serum concentration of Colchicine can be increased when it is combined with Rilpivirine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Colchicine.
RitonavirThe serum concentration of Colchicine can be decreased when it is combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Colchicine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Colchicine.
RolapitantThe serum concentration of Colchicine can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Colchicine.
RosuvastatinColchicine may increase the myopathic rhabdomyolysis activities of Rosuvastatin.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Colchicine.
SaquinavirThe serum concentration of Colchicine can be decreased when it is combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Colchicine.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Colchicine.
ScopolamineThe serum concentration of Colchicine can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Colchicine can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Colchicine.
SertralineThe serum concentration of Colchicine can be increased when it is combined with Sertraline.
SildenafilThe metabolism of Colchicine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Colchicine.
SiltuximabThe serum concentration of Colchicine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Colchicine can be increased when it is combined with Simeprevir.
SimvastatinColchicine may increase the myopathic rhabdomyolysis activities of Simvastatin.
SimvastatinThe serum concentration of Colchicine can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Colchicine can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Colchicine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Colchicine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Colchicine.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Colchicine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Colchicine.
SpironolactoneThe serum concentration of Colchicine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Colchicine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Colchicine can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Colchicine can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Colchicine can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Colchicine can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Colchicine can be decreased when combined with Sulfisoxazole.
SumatriptanThe serum concentration of Colchicine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Colchicine can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Colchicine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Colchicine can be decreased when it is combined with Tacrolimus.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Colchicine.
TamoxifenThe serum concentration of Colchicine can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Colchicine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Colchicine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Colchicine.
TelaprevirThe serum concentration of Colchicine can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Colchicine can be increased when it is combined with Telithromycin.
TelmisartanThe serum concentration of Colchicine can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Colchicine.
TerazosinThe serum concentration of Colchicine can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Colchicine can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Colchicine can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Colchicine can be increased when it is combined with Testosterone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Colchicine.
TiclopidineThe metabolism of Colchicine can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Colchicine.
TipranavirThe serum concentration of Colchicine can be increased when it is combined with Tipranavir.
TocilizumabThe serum concentration of Colchicine can be decreased when it is combined with Tocilizumab.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Colchicine.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Colchicine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Colchicine.
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Colchicine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Colchicine.
TrazodoneThe serum concentration of Colchicine can be decreased when it is combined with Trazodone.
TrifluoperazineThe serum concentration of Colchicine can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Colchicine can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Colchicine can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Colchicine can be increased when it is combined with Trimipramine.
TroleandomycinThe serum concentration of Colchicine can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Colchicine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Colchicine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Colchicine.
VenlafaxineThe metabolism of Colchicine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Colchicine.
VerapamilThe metabolism of Colchicine can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Colchicine.
VinblastineThe serum concentration of Colchicine can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Colchicine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Colchicine.
VincristineThe serum concentration of Colchicine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Colchicine can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Colchicine.
VoriconazoleThe serum concentration of Colchicine can be increased when it is combined with Voriconazole.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Colchicine.
ZimelidineThe serum concentration of Colchicine can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Colchicine can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid alcohol since it increases uric acid levels.
  • Drink liberally.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Structural constituent of cytoskeleton
Specific Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name:
TUBB1
Uniprot ID:
Q9H4B7
Molecular Weight:
50326.56 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. doi: 10.1021/bi900152k. [PubMed:19527023 ]
  4. Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Oct;45(10):1160-6. doi: 10.1002/jms.1804. [PubMed:20814887 ]
  5. Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y: Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010 Jun;48(5):407-14. doi: 10.3109/15563650.2010.495348. [PubMed:20586571 ]
  6. Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. [PubMed:15720245 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Ubiquitin protein ligase binding
Specific Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name:
TUBB
Uniprot ID:
P07437
Molecular Weight:
49670.515 Da
References
  1. Yee KW, Hagey A, Verstovsek S, Cortes J, Garcia-Manero G, O'Brien SM, Faderl S, Thomas D, Wierda W, Kornblau S, Ferrajoli A, Albitar M, McKeegan E, Grimm DR, Mueller T, Holley-Shanks RR, Sahelijo L, Gordon GB, Kantarjian HM, Giles FJ: Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res. 2005 Sep 15;11(18):6615-24. [PubMed:16166440 ]
  2. Acharya BR, Choudhury D, Das A, Chakrabarti G: Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. doi: 10.1021/bi900152k. [PubMed:19527023 ]
  3. Li CM, Lu Y, Ahn S, Narayanan R, Miller DD, Dalton JT: Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin. J Mass Spectrom. 2010 Oct;45(10):1160-6. doi: 10.1002/jms.1804. [PubMed:20814887 ]
  4. Cerquaglia C, Diaco M, Nucera G, La Regina M, Montalto M, Manna R: Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):117-24. [PubMed:15720245 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi ...
Gene Name:
ABCB4
Uniprot ID:
P21439
Molecular Weight:
141521.845 Da
References
  1. Vollrath V, Wielandt AM, Acuna C, Duarte I, Andrade L, Chianale J: Effect of colchicine and heat shock on multidrug resistance gene and P-glycoprotein expression in rat liver. J Hepatol. 1994 Nov;21(5):754-63. [PubMed:7890890 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Toxin transporter activity
Specific Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular Weight:
61279.485 Da
References
  1. Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. [PubMed:10196521 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. [PubMed:11602674 ]
  2. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  3. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  4. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. [PubMed:12948019 ]
  5. Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, Pastan I: Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8472-6. [PubMed:1356264 ]
  6. Bebawy M, Morris MB, Roufogalis BD: A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles. Anal Biochem. 1999 Mar 15;268(2):270-7. [PubMed:10075817 ]
  7. Kuo CC, Hsieh HP, Pan WY, Chen CP, Liou JP, Lee SJ, Chang YL, Chen LT, Chen CT, Chang JY: BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res. 2004 Jul 1;64(13):4621-8. [PubMed:15231674 ]
  8. Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR Jr, Chen X, Chen ZS: Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. doi: 10.1016/j.bcp.2009.04.002. Epub 2009 Apr 11. [PubMed:19427995 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Stride BD, Grant CE, Loe DW, Hipfner DR, Cole SP, Deeley RG: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. [PubMed:9281595 ]
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Drug created on July 08, 2007 11:02 / Updated on September 28, 2016 02:27