Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.
Article Details
- CitationCopy to clipboard
Sidorova YA, Grishanova AY
Dose- and time-dependent effects of menadione on enzymes of xenobiotic metabolism in rat liver.
Bull Exp Biol Med. 2004 Mar;137(3):231-4. doi: 10.1023/b:bebm.0000031556.47763.04.
- PubMed ID
- 15232626 [ View in PubMed]
- Abstract
We studied the effect of synthetic vitamin K analogue menadione on enzymes of xenobiotic metabolism in rat liver (total content of cytochrome P450 and catalytic activities of CYP1A1/2, CYP2B1, CYP2C, NADPH-cytochrome P450 reductase, and glutathione S-transferase). Menadione induced phase I and II enzymes for metabolism of xenobiotics, drugs, and procarcinogens. The effect of menadione depended on its dose and duration of treatment.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Menadione Cytochrome P450 1A1 Protein Humans UnknownInhibitorInducerDetails