Intoxication after extreme oral overdose of quetiapine to attempt suicide: pharmacological concerns of side effects.

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Muller C, Reuter H, Dohmen C

Intoxication after extreme oral overdose of quetiapine to attempt suicide: pharmacological concerns of side effects.

Case Rep Med. 2009;2009:371698. doi: 10.1155/2009/371698. Epub 2010 Jan 3.

PubMed ID

20066171 [ View in PubMed

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Abstract

Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders. Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QT(c)-prolongation, somnolence, and hyperglycemia. Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism. QT(c)-interval was moderately extended. Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v. saline, and observation for 17 hours on an intensive care unit. Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Quetiapine	Muscarinic acetylcholine receptor M3	Protein	Humans	Unknown	Antagonist	Details