You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameQuetiapine
Accession NumberDB01224  (APRD00675)
TypeSmall Molecule
GroupsApproved
Description

Quetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

Structure
Thumb
Synonyms
2-[2-(4-Dibenzo[b,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
Quetiapina
Quetiapine
Quetiapine fumarate
Quetiapine hemifumarate
Quetiapinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Abbott-quetiapinetablet (immediate release)100 mgoralBgp Pharma Ulc2014-06-092015-12-31Canada
Abbott-quetiapinetablet (immediate release)25 mgoralBgp Pharma Ulc2014-06-092015-12-31Canada
Abbott-quetiapinetablet (immediate release)300 mgoralBgp Pharma Ulc2014-06-092015-12-31Canada
Abbott-quetiapinetablet (immediate release)200 mgoralBgp Pharma Ulc2014-06-132015-12-31Canada
Accel-quetiapinetablet300 mgoralAccel Pharma Inc2015-03-26Not applicableCanada
Accel-quetiapinetablet200 mgoralAccel Pharma Inc2015-03-26Not applicableCanada
Accel-quetiapinetablet150 mgoralAccel Pharma Inc2015-03-03Not applicableCanada
Accel-quetiapinetablet100 mgoralAccel Pharma Inc2015-03-26Not applicableCanada
Accel-quetiapinetablet25 mgoralAccel Pharma Inc2015-03-26Not applicableCanada
Ach-quetiapine Fumarate XRtablet (extended-release)400 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-quetiapine Fumarate XRtablet (extended-release)300 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-quetiapine Fumarate XRtablet (extended-release)200 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-quetiapine Fumarate XRtablet (extended-release)150 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Ach-quetiapine Fumarate XRtablet (extended-release)50 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Act Quetiapinetablet100 mgoralActavis Pharma Company2008-09-04Not applicableCanada
Act Quetiapinetablet25 mgoralActavis Pharma Company2008-09-04Not applicableCanada
Act Quetiapinetablet150 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Act Quetiapinetablet300 mgoralActavis Pharma Company2008-09-04Not applicableCanada
Act Quetiapinetablet200 mgoralActavis Pharma Company2008-09-04Not applicableCanada
Auro-quetiapinetablet300 mgoralAuro Pharma Inc2012-10-18Not applicableCanada
Auro-quetiapinetablet200 mgoralAuro Pharma Inc2012-10-18Not applicableCanada
Auro-quetiapinetablet100 mgoralAuro Pharma Inc2012-10-18Not applicableCanada
Auro-quetiapinetablet25 mgoralAuro Pharma Inc2012-10-18Not applicableCanada
Auro-quetiapinetablet150 mgoralAuro Pharma IncNot applicableNot applicableCanada
Ava-quetiapinetablet25 mgoralAvanstra Inc2011-11-282014-08-21Canada
Ava-quetiapinetablet200 mgoralAvanstra Inc2011-11-282014-08-21Canada
Ava-quetiapinetablet100 mgoralAvanstra Inc2011-11-282014-08-21Canada
Bio-quetiapinetablet300 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-quetiapinetablet200 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-quetiapinetablet150 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-quetiapinetablet100 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-quetiapinetablet25 mgoralBiomed PharmaNot applicableNot applicableCanada
Dom-quetiapinetablet300 mgoralDominion Pharmacal2010-07-01Not applicableCanada
Dom-quetiapinetablet200 mgoralDominion Pharmacal2010-05-01Not applicableCanada
Dom-quetiapinetablet100 mgoralDominion Pharmacal2010-06-01Not applicableCanada
Dom-quetiapinetablet150 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-quetiapinetablet25 mgoralDominion Pharmacal2010-05-01Not applicableCanada
Ipg-quetiapinetablet (immediate release)25 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-quetiapinetablet (immediate release)300 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-quetiapinetablet (immediate release)200 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-quetiapinetablet (immediate release)100 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-quetiapinetablet100 mgoralJamp Pharma Corporation2010-04-02Not applicableCanada
Jamp-quetiapinetablet25 mgoralJamp Pharma Corporation2010-04-02Not applicableCanada
Jamp-quetiapinetablet150 mgoralJamp Pharma CorporationNot applicableNot applicableCanada
Jamp-quetiapinetablet300 mgoralJamp Pharma Corporation2010-06-18Not applicableCanada
Jamp-quetiapinetablet200 mgoralJamp Pharma Corporation2010-04-02Not applicableCanada
Mar-quetiapinetablet (immediate release)25 mgoralMarcan Pharmaceuticals Inc2014-01-16Not applicableCanada
Mar-quetiapinetablet (immediate release)300 mgoralMarcan Pharmaceuticals Inc2014-01-16Not applicableCanada
Mar-quetiapinetablet (immediate release)200 mgoralMarcan Pharmaceuticals Inc2014-01-16Not applicableCanada
Mar-quetiapinetablet (immediate release)100 mgoralMarcan Pharmaceuticals Inc2014-01-16Not applicableCanada
Mint-quetiapinetablet300 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada
Mint-quetiapinetablet200 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada
Mint-quetiapinetablet150 mgoralMint Pharmaceuticals IncNot applicableNot applicableCanada
Mint-quetiapinetablet100 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada
Mint-quetiapinetablet25 mgoralMint Pharmaceuticals Inc2015-03-19Not applicableCanada
Mylan-quetiapinetablet25 mgoralMylan Pharmaceuticals Ulc2008-09-04Not applicableCanada
Mylan-quetiapinetablet100 mgoralMylan Pharmaceuticals Ulc2008-09-04Not applicableCanada
Mylan-quetiapinetablet300 mgoralMylan Pharmaceuticals Ulc2008-09-04Not applicableCanada
Mylan-quetiapinetablet200 mgoralMylan Pharmaceuticals Ulc2008-09-04Not applicableCanada
Nat-quetiapinetablet100 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-quetiapinetablet25 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-quetiapinetablet300 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-quetiapinetablet200 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-quetiapinetablet150 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nu-quetiapinetablet25 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-quetiapinetablet300 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-quetiapinetablet200 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-quetiapinetablet100 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-quetiapinetablet25 mgoralPharmel Inc2010-02-18Not applicableCanada
PHL-quetiapinetablet300 mgoralPharmel Inc2010-02-18Not applicableCanada
PHL-quetiapinetablet200 mgoralPharmel Inc2010-02-18Not applicableCanada
PHL-quetiapinetablet100 mgoralPharmel Inc2010-02-18Not applicableCanada
PMS-quetiapinetablet25 mgoralPharmascience Inc2008-09-04Not applicableCanada
PMS-quetiapinetablet50 mgoralPharmascience Inc2011-01-21Not applicableCanada
PMS-quetiapinetablet150 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-quetiapinetablet300 mgoralPharmascience Inc2008-09-04Not applicableCanada
PMS-quetiapinetablet200 mgoralPharmascience Inc2008-09-04Not applicableCanada
PMS-quetiapinetablet100 mgoralPharmascience Inc2008-09-04Not applicableCanada
Priva-quetiapinetablet150 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-quetiapinetablet100 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-quetiapinetablet25 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-quetiapinetablet300 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-quetiapinetablet200 mgoralPharmapar IncNot applicableNot applicableCanada
Pro-quetiapinetablet100 mgoralPro Doc Limitee2008-10-23Not applicableCanada
Pro-quetiapinetablet200 mgoralPro Doc Limitee2008-10-23Not applicableCanada
Pro-quetiapinetablet25 mgoralPro Doc Limitee2008-10-23Not applicableCanada
Pro-quetiapinetablet300 mgoralPro Doc Limitee2008-10-23Not applicableCanada
Quetiapinetablet300 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Quetiapinetablet200 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Quetiapinetablet300 mgoralSanis Health Inc2010-07-26Not applicableCanada
Quetiapinetablet150 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Quetiapinetablet200 mgoralSanis Health Inc2010-07-26Not applicableCanada
Quetiapinetablet300 mgoralSivem Pharmaceuticals Ulc2009-02-26Not applicableCanada
Quetiapinetablet100 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Quetiapinetablet100 mgoralSanis Health Inc2010-07-26Not applicableCanada
Quetiapinetablet200 mgoralSivem Pharmaceuticals Ulc2009-02-26Not applicableCanada
Quetiapinetablet25 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Quetiapinetablet25 mgoralSanis Health Inc2010-07-26Not applicableCanada
Quetiapinetablet100 mgoralSivem Pharmaceuticals Ulc2009-02-26Not applicableCanada
Quetiapinetablet25 mgoralSivem Pharmaceuticals Ulc2009-02-26Not applicableCanada
Quetiapine Tabletstablet25 mgoralAccord Healthcare Inc2012-06-20Not applicableCanada
Quetiapine Tabletstablet100 mgoralAccord Healthcare Inc2012-06-20Not applicableCanada
Quetiapine Tabletstablet300 mgoralAccord Healthcare Inc2012-06-20Not applicableCanada
Quetiapine Tabletstablet200 mgoralAccord Healthcare Inc2012-06-20Not applicableCanada
Quetiapine Tabletstablet150 mgoralAccord Healthcare Inc2012-06-20Not applicableCanada
Quetiapine XRtablet (extended-release)300 mgoralPro Doc Limitee2014-01-09Not applicableCanada
Quetiapine XRtablet (extended-release)400 mgoralPro Doc Limitee2014-01-09Not applicableCanada
Quetiapine XRtablet (extended-release)50 mgoralPro Doc Limitee2014-01-09Not applicableCanada
Quetiapine XRtablet (extended-release)200 mgoralPro Doc Limitee2014-01-09Not applicableCanada
Quetiapine XRtablet (extended-release)400 mgoralSivem Pharmaceuticals Ulc2014-01-16Not applicableCanada
Quetiapine XRtablet (extended-release)150 mgoralPro Doc Limitee2014-01-09Not applicableCanada
Quetiapine XRtablet (extended-release)300 mgoralSivem Pharmaceuticals Ulc2014-01-16Not applicableCanada
Quetiapine XRtablet (extended-release)200 mgoralSivem Pharmaceuticals Ulc2014-01-16Not applicableCanada
Quetiapine XRtablet (extended-release)150 mgoralSivem Pharmaceuticals Ulc2014-01-16Not applicableCanada
Quetiapine XRtablet (extended-release)50 mgoralSivem Pharmaceuticals Ulc2014-01-01Not applicableCanada
Ran-quetiapinetablet300 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-01-17Not applicableCanada
Ran-quetiapinetablet200 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-01-17Not applicableCanada
Ran-quetiapinetablet100 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-01-17Not applicableCanada
Ran-quetiapinetablet25 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-01-17Not applicableCanada
Ratio-quetiapinetablet300 mgoralRatiopharm Inc Division Of Teva Canada Limited2008-08-272014-09-19Canada
Ratio-quetiapinetablet200 mgoralRatiopharm Inc Division Of Teva Canada Limited2008-08-272014-09-19Canada
Ratio-quetiapinetablet100 mgoralRatiopharm Inc Division Of Teva Canada Limited2008-08-272014-09-19Canada
Ratio-quetiapinetablet25 mgoralRatiopharm Inc Division Of Teva Canada Limited2008-08-222014-09-19Canada
Riva-quetiapinetablet300 mgoralLaboratoire Riva Inc2008-09-24Not applicableCanada
Riva-quetiapinetablet150 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-quetiapinetablet200 mgoralLaboratoire Riva Inc2008-09-24Not applicableCanada
Riva-quetiapinetablet100 mgoralLaboratoire Riva Inc2008-09-24Not applicableCanada
Riva-quetiapinetablet25 mgoralLaboratoire Riva Inc2008-09-24Not applicableCanada
Sandoz Quetiapinetablet300 mgoralSandoz Canada Incorporated2008-09-04Not applicableCanada
Sandoz Quetiapinetablet200 mgoralSandoz Canada Incorporated2008-09-04Not applicableCanada
Sandoz Quetiapinetablet100 mgoralSandoz Canada Incorporated2008-09-04Not applicableCanada
Sandoz Quetiapinetablet25 mgoralSandoz Canada Incorporated2008-09-04Not applicableCanada
Sandoz Quetiapine XRtablet (extended-release)300 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Quetiapine XRtablet (extended-release)50 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Quetiapine XRtablet (extended-release)200 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Quetiapine XRtablet (extended-release)150 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Quetiapine XRtablet (extended-release)400 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Quetiapine Xrttablet (extended-release)50 mgoralSandoz Canada Incorporated2013-06-14Not applicableCanada
Sandoz Quetiapine Xrttablet (extended-release)150 mgoralSandoz Canada Incorporated2013-06-14Not applicableCanada
Sandoz Quetiapine Xrttablet (extended-release)400 mgoralSandoz Canada Incorporated2013-06-14Not applicableCanada
Sandoz Quetiapine Xrttablet (extended-release)300 mgoralSandoz Canada Incorporated2013-06-14Not applicableCanada
Sandoz Quetiapine Xrttablet (extended-release)200 mgoralSandoz Canada Incorporated2013-06-14Not applicableCanada
Seroqueltablet, film coated300 mg/1oralPhysicians Total Care, Inc.2011-11-18Not applicableUs
Seroqueltablet, film coated300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-07Not applicableUs
Seroqueltablet, film coated200 mg/1oralRebel Distributors Corp2010-06-01Not applicableUs
Seroqueltablet, film coated25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-07-19Not applicableUs
Seroqueltablet, film coated50 mg/1oralPhysicians Total Care, Inc.2006-04-28Not applicableUs
Seroqueltablet, film coated100 mg/1oralRebel Distributors Corp2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralAstra Zeneca Pharmaceuticals Lp1997-10-01Not applicableUs
Seroqueltablet, film coated25 mg/1oralPhysicians Total Care, Inc.2003-11-19Not applicableUs
Seroqueltablet, film coated50 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-16Not applicableUs
Seroqueltablet, film coated200 mg/1oralPd Rx Pharmaceuticals, Inc.1997-10-01Not applicableUs
Seroqueltablet, film coated400 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated50 mg/1oralRebel Distributors Corp2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-18Not applicableUs
Seroqueltablet, film coated300 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated25 mg/1oralRebel Distributors Corp2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralPhysicians Total Care, Inc.2006-04-28Not applicableUs
Seroqueltablet, film coated25 mg/1oralREMEDYREPACK INC.2013-05-092016-04-05Us
Seroqueltablet, film coated200 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated400 mg/1oralSTAT Rx USA LLC2011-05-26Not applicableUs
Seroqueltablet, film coated400 mg/1oralAstra Zeneca Pharmaceuticals Lp2006-02-13Not applicableUs
Seroqueltablet, film coated200 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-07-08Not applicableUs
Seroqueltablet, film coated50 mg/1oralREMEDYREPACK INC.2013-05-142016-03-11Us
Seroqueltablet, film coated50 mg/1oralbryant ranch prepack2006-02-13Not applicableUs
Seroqueltablet, film coated300 mg/1oralCardinal Health2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralSTAT Rx USA LLC2011-05-26Not applicableUs
Seroqueltablet, film coated50 mg/1oralAstra Zeneca Pharmaceuticals Lp2006-02-13Not applicableUs
Seroqueltablet, film coated25 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-16Not applicableUs
Seroqueltablet, film coated400 mg/1oralREMEDYREPACK INC.2013-04-102016-03-11Us
Seroqueltablet, film coated300 mg/1oralbryant ranch prepack2000-11-13Not applicableUs
Seroqueltablet, film coated200 mg/1oralCardinal Health2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-04-16Not applicableUs
Seroqueltablet, film coated300 mg/1oralREMEDYREPACK INC.2013-04-102016-03-11Us
Seroqueltablet, film coated200 mg/1oralbryant ranch prepack1997-10-01Not applicableUs
Seroqueltablet, film coated100 mg/1oralCardinal Health2010-06-01Not applicableUs
Seroqueltablet, film coated50 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated25 mg/1oralAstra Zeneca Pharmaceuticals Lp2003-06-30Not applicableUs
Seroqueltablet, film coated50 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Seroqueltablet, film coated200 mg/1oralREMEDYREPACK INC.2013-04-102016-04-05Us
Seroqueltablet, film coated25 mg/1oralbryant ranch prepack2003-06-30Not applicableUs
Seroqueltablet, film coated25 mg/1oralCardinal Health2010-06-01Not applicableUs
Seroqueltablet, film coated25 mg/1oralContract Pharmacy Services Pa2010-06-01Not applicableUs
Seroqueltablet, film coated300 mg/1oralAstra Zeneca Pharmaceuticals Lp2000-11-13Not applicableUs
Seroqueltablet, extended release150 mg/1oralREMEDYREPACK INC.2011-03-23Not applicableUs
Seroqueltablet, film coated100 mg/1oralREMEDYREPACK INC.2013-04-242016-03-04Us
Seroqueltablet, film coated100 mg/1oralbryant ranch prepack1997-10-01Not applicableUs
Seroqueltablet, film coated200 mg/1oralAstra Zeneca Pharmaceuticals Lp1997-10-01Not applicableUs
Seroquel 150 mgtablet150 mgoralAstrazeneca Canada Inc2001-01-102006-03-03Canada
Seroquel 300 mgtablet300 mgoralAstrazeneca Canada Inc2001-08-21Not applicableCanada
Seroquel Tab 100mgtablet100 mgoralAstrazeneca Canada Inc1997-12-10Not applicableCanada
Seroquel Tab 200mgtablet200 mgoralAstrazeneca Canada Inc1997-12-10Not applicableCanada
Seroquel Tab 25mgtablet25 mgoralAstrazeneca Canada Inc1997-12-10Not applicableCanada
Seroquel XRtablet, extended release200 mg/1oralTYA Pharmaceuticals2007-07-16Not applicableUs
Seroquel XRtablet, extended release300 mg/1oralTYA Pharmaceuticals2007-07-16Not applicableUs
Seroquel XRtablet, extended release200 mg/1oralAstra Zeneca Pharmaceuticals Lp2007-07-16Not applicableUs
Seroquel XRtablet, extended release150 mg/1oralTYA Pharmaceuticals2009-02-01Not applicableUs
Seroquel XRtablet (extended-release)400 mgoralAstrazeneca Canada Inc2007-09-27Not applicableCanada
Seroquel XRtablet, extended release150 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-02-01Not applicableUs
Seroquel XRtablet, extended release50 mg/1oralTYA Pharmaceuticals2009-02-01Not applicableUs
Seroquel XRtablet (extended-release)300 mgoralAstrazeneca Canada Inc2007-09-27Not applicableCanada
Seroquel XRtablet, extended release50 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-02-01Not applicableUs
Seroquel XRtablet (extended-release)150 mgoralAstrazeneca Canada Inc2009-04-14Not applicableCanada
Seroquel XRtablet (extended-release)200 mgoralAstrazeneca Canada Inc2007-09-27Not applicableCanada
Seroquel XRtablet (extended-release)50 mgoralAstrazeneca Canada Inc2007-09-27Not applicableCanada
Seroquel XRkitAstra Zeneca Pharmaceuticals Lp2014-10-02Not applicableUs
Seroquel XRtablet, extended release400 mg/1oralAstra Zeneca Pharmaceuticals Lp2007-07-16Not applicableUs
Seroquel XRtablet, extended release50 mg/1oralPhysicians Total Care, Inc.2011-11-17Not applicableUs
Seroquel XRtablet, extended release400 mg/1oralTYA Pharmaceuticals2007-07-16Not applicableUs
Seroquel XRtablet, extended release300 mg/1oralAstra Zeneca Pharmaceuticals Lp2007-07-16Not applicableUs
Teva-quetiapinetablet300 mgoralTeva Canada Limited2008-09-04Not applicableCanada
Teva-quetiapinetablet200 mgoralTeva Canada Limited2008-09-04Not applicableCanada
Teva-quetiapinetablet150 mgoralTeva Canada Limited2008-09-04Not applicableCanada
Teva-quetiapinetablet100 mgoralTeva Canada Limited2008-09-04Not applicableCanada
Teva-quetiapinetablet25 mgoralTeva Canada Limited2008-09-04Not applicableCanada
Teva-quetiapine XRtablet (extended-release)50 mgoralTeva Canada Limited2013-03-08Not applicableCanada
Teva-quetiapine XRtablet (extended-release)400 mgoralTeva Canada Limited2013-03-08Not applicableCanada
Teva-quetiapine XRtablet (extended-release)300 mgoralTeva Canada Limited2013-03-08Not applicableCanada
Teva-quetiapine XRtablet (extended-release)200 mgoralTeva Canada Limited2013-03-08Not applicableCanada
Teva-quetiapine XRtablet (extended-release)150 mgoralTeva Canada Limited2013-03-08Not applicableCanada
Torrent-quetiapine Fumaratetablet (immediate release)25 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-quetiapine Fumaratetablet (immediate release)300 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-quetiapine Fumaratetablet (immediate release)200 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-quetiapine Fumaratetablet (immediate release)100 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Van-quetiapinetablet25 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Van-quetiapinetablet100 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Van-quetiapinetablet300 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Van-quetiapinetablet200 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-quetiapinetablet300 mgoralApotex Inc2008-09-04Not applicableCanada
Apo-quetiapinetablet200 mgoralApotex Inc2008-09-04Not applicableCanada
Apo-quetiapinetablet100 mgoralApotex Inc2008-09-04Not applicableCanada
Apo-quetiapinetablet25 mgoralApotex Inc2008-09-04Not applicableCanada
Quetiapine Fumaratetablet25 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralMc Kesson Contract Packaging2012-03-27Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralMajor Pharmaceuticals2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2013-07-17Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralREMEDYREPACK INC.2013-02-07Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2013-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralUnit Dose Services2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralTeva Pharmaceuticals USA Inc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2013-02-07Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralREMEDYREPACK INC.2014-05-282016-04-05Us
Quetiapine Fumaratetablet300 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralREMEDYREPACK INC.2013-02-09Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated150 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralREMEDYREPACK INC.2014-10-13Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralbryant ranch prepack2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralREMEDYREPACK INC.2015-12-24Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralREMEDYREPACK INC.2015-02-16Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralTYA Pharmaceuticals2012-03-26Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralbryant ranch prepack2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-02-07Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralREMEDYREPACK INC.2013-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralUnit Dose Services2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralTeva Pharmaceuticals USA Inc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralREMEDYREPACK INC.2014-05-28Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralClinical Solutions Wholesale, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralREMEDYREPACK INC.2014-10-08Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralbryant ranch prepack2012-03-26Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralREMEDYREPACK INC.2015-10-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralTYA Pharmaceuticals2012-03-26Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAvera Mc Kennan Hospital2015-03-01Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralREMEDYREPACK INC.2013-02-08Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralTeva Pharmaceuticals USA Inc2014-03-12Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralPhysicians Total Care, Inc.2012-04-12Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralREMEDYREPACK INC.2014-04-14Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2014-10-08Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralProficient Rx LP2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralREMEDYREPACK INC.2015-08-31Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralTYA Pharmaceuticals2012-03-26Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAvera Mc Kennan Hospital2015-07-29Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralREMEDYREPACK INC.2013-02-08Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralPhysicians Total Care, Inc.2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralREMEDYREPACK INC.2013-09-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralREMEDYREPACK INC.2014-10-08Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralProficient Rx LP2012-03-26Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralREMEDYREPACK INC.2015-07-16Not applicableUs
Quetiapine Fumaratetablet, film coated150 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-04-05Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAvera Mc Kennan Hospital2015-04-16Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralMajor Pharmaceuticals2014-06-16Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2013-02-15Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralPhysicians Total Care, Inc.2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2013-05-292016-04-05Us
Quetiapine Fumaratetablet, film coated100 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralProficient Rx LP2012-03-26Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralREMEDYREPACK INC.2015-07-14Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralAvera Mc Kennan Hospital2015-03-09Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralJubilant Cadista Pharmaceuticals Inc.2013-11-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralMajor Pharmaceuticals2012-04-02Not applicableUs
Quetiapine Fumaratetablet150 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralCardinal Health2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralDIRECT RX2015-01-01Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralREMEDYREPACK INC.2015-06-29Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralPreferred Pharmaceuticals, Inc.2014-03-31Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralBlue Point Laboratories2013-02-28Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2016-01-29Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralMajor Pharmaceuticals2012-04-02Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralNorth Star Rx Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralTeva Pharmaceuticals USA Inc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-02-08Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralPhysicians Total Care, Inc.2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralDIRECT RX2015-01-01Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralREMEDYREPACK INC.2015-05-26Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAurobindo Pharma Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralbryant ranch prepack2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-23Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralREMEDYREPACK INC.2016-01-29Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralMajor Pharmaceuticals2012-04-02Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralSTAT Rx USA LLC2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralAlembic Pharmaceuticals Limited2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralTeva Pharmaceuticals USA Inc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralREMEDYREPACK INC.2013-02-15Not applicableUs
Quetiapine Fumaratetablet200 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralPhysicians Total Care, Inc.2012-04-02Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralREMEDYREPACK INC.2013-05-282016-04-05Us
Quetiapine Fumaratetablet50 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralTYA Pharmaceuticals2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralbryant ranch prepack2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated100 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Quetiapine Fumaratetablet150 mg/1oralAscend Laboratories, LLC2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralGolden State Medical Supply, Inc.2015-07-21Not applicableUs
Quetiapine Fumaratetablet400 mg/1oralLupin Pharmaceuticals, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralLUPIN LIMITED2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralREMEDYREPACK INC.2016-01-20Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralMajor Pharmaceuticals2012-04-02Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralSandoz Inc2013-04-05Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralNorthstar Rx LLC2015-01-12Not applicableUs
Quetiapine Fumaratetablet300 mg/1oralTorrent Pharmaceuticals Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAv Kare, Inc.2014-01-17Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralAccord Healthcare Inc.2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralSun Pharma Global FZE2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated400 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralBreckenridge Pharmaceutical, Inc2012-03-26Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralTeva Pharmaceuticals USA Inc2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralREMEDYREPACK INC.2013-02-18Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralRoxane Laboratories, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet50 mg/1oralREMEDYREPACK INC.2014-07-09Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Quetiapine Fumaratetablet100 mg/1oralCardinal Health2013-03-01Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralDr.Reddy's Laboratories Limited2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated50 mg/1oralClinical Solutions Wholesale2012-03-28Not applicableUs
Quetiapine Fumaratetablet, film coated25 mg/1oralCitron Pharma LLC2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralApotex Corp.2012-03-27Not applicableUs
Quetiapine Fumaratetablet, film coated300 mg/1oralGolden State Medical Supply, Inc.2012-03-27Not applicableUs
Quetiapine Fumaratetablet25 mg/1oralREMEDYREPACK INC.2015-12-24Not applicableUs
Quetiapine Fumaratetablet, film coated200 mg/1oralREMEDYREPACK INC.2015-03-12Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIBGL0JSY5SI
CAS number111974-69-7
WeightAverage: 383.507
Monoisotopic: 383.166747749
Chemical FormulaC21H25N3O2S
InChI KeyInChIKey=URKOMYMAXPYINW-UHFFFAOYSA-N
InChI
InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
IUPAC Name
2-[2-(4-{2-thia-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol
SMILES
OCCOCCN1CCN(CC1)C1=NC2=CC=CC=C2SC2=CC=CC=C12
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dibenzothiazepines. These are compounds containing a dibenzothiazepine moiety, which consists of two benzene connected by a thiazepine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazepines
Sub ClassDibenzothiazepines
Direct ParentDibenzothiazepines
Alternative Parents
Substituents
  • Dibenzothiazepine
  • Diarylthioether
  • N-alkylpiperazine
  • Imidolactam
  • Benzenoid
  • Piperazine
  • 1,4-diazinane
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Thioether
  • Ether
  • Dialkyl ether
  • Carboxylic acid amidine
  • Amidine
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of schizophrenia and related psychotic disorders.
PharmacodynamicsQuetiapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia. Quetiapine is a selective monoaminergic antagonist with high affinity for the serotonin Type 2 (5HT2), and dopamine type 2 (D2) receptors. Quetiapine is an antagonist at serotonin 5-HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic alpha 1 and alpha 2 receptors. Quetiapine has no significant affinity for cholinergic muscarinic or benzodiazepine receptors. Drowsiness and orthostatic hypotension associated with use of quetiapine may be explained by its antagonism of histamine H1 and adrenergic alpha 1 receptors, respectively. Quetiapine's antagonism of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.
Mechanism of actionQuetiapine's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
Related Articles
AbsorptionRapidly and well absorbed.
Volume of distribution
  • 10±4 L/kg
Protein binding83%
Metabolism

Hepatic. The major metabolic pathways are sulfoxidation, mediated by cytochrome P450 3A4 (CYP3A4), and oxidation of the terminal alcohol to a carboxylic acid. The major sulfoxide metabolite of quetiapine is inactive. Quetiapine also undergoes hydroxylation of the dibenzothiazepine ring, O-deakylation, N-dealkylation, and phase II conjugation. The 7-hydroxy and 7-hydroxy- N-delakylated metabolites appear to be active, but are present in very low concentrations.

Route of eliminationElimination of quetiapine is mainly via hepatic metabolism. Following a single oral dose of 14C-quetiapine, less than 1% of the administered dose was excreted as unchanged drug, indicating that quetiapine is highly metabolized. Approximately 73% and 20% of the dose was recovered in the urine and feces, respectively.
Half life6 hours
ClearanceNot Available
ToxicitySymptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9155
Blood Brain Barrier+0.9906
Caco-2 permeable-0.6037
P-glycoprotein substrateSubstrate0.8424
P-glycoprotein inhibitor IInhibitor0.9117
P-glycoprotein inhibitor IIInhibitor0.9325
Renal organic cation transporterInhibitor0.5554
CYP450 2C9 substrateNon-substrate0.6438
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateNon-substrate0.6049
CYP450 1A2 substrateInhibitor0.5744
CYP450 2C9 inhibitorNon-inhibitor0.6305
CYP450 2D6 inhibitorInhibitor0.588
CYP450 2C19 inhibitorNon-inhibitor0.7033
CYP450 3A4 inhibitorInhibitor0.7961
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.5375
Ames testNon AMES toxic0.7479
CarcinogenicityNon-carcinogens0.869
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6537 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9483
hERG inhibition (predictor II)Inhibitor0.8684
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet (immediate release)oral100 mg
Tablet (immediate release)oral200 mg
Tablet (immediate release)oral25 mg
Tablet (immediate release)oral300 mg
Tabletoral50 mg
Tabletoral100 mg/1
Tabletoral150 mg/1
Tabletoral200 mg/1
Tabletoral25 mg/1
Tabletoral300 mg/1
Tabletoral400 mg/1
Tabletoral50 mg/1
Tablet, film coatedoral100 mg/1
Tablet, film coatedoral150 mg/1
Tablet, film coatedoral200 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral300 mg/1
Tablet, film coatedoral400 mg/1
Tablet, film coatedoral50 mg/1
Tabletoral300 mg
Tabletoral100 mg
Tabletoral200 mg
Tabletoral25 mg
Kit
Tablet (extended-release)oral150 mg
Tablet (extended-release)oral200 mg
Tablet (extended-release)oral300 mg
Tablet (extended-release)oral400 mg
Tablet (extended-release)oral50 mg
Tablet, extended releaseoral150 mg/1
Tablet, extended releaseoral200 mg/1
Tablet, extended releaseoral300 mg/1
Tablet, extended releaseoral400 mg/1
Tablet, extended releaseoral50 mg/1
Tabletoral150 mg
Prices
Unit descriptionCostUnit
Seroquel 400 mg tablet16.71USD tablet
Seroquel xr 400 mg tablet14.82USD tablet
Seroquel 300 mg tablet14.21USD tablet
Seroquel xr 300 mg tablet12.61USD tablet
Seroquel 200 mg tablet10.84USD tablet
SEROquel XR 200 mg 24 Hour tablet10.0USD tablet
Seroquel xr 200 mg tablet9.62USD tablet
SEROquel XR 150 mg 24 Hour tablet9.09USD tablet
Seroquel xr 150 mg tablet8.74USD tablet
Seroquel 100 mg tablet5.75USD tablet
Seroquel 50 mg tablet5.5USD tablet
SEROquel XR 50 mg 24 Hour tablet5.06USD tablet
Seroquel xr 50 mg tablet4.87USD tablet
Seroquel 300 mg Tablet4.35USD tablet
Seroquel 25 mg tablet3.35USD tablet
Seroquel 200 mg Tablet2.98USD tablet
Apo-Quetiapine 300 mg Tablet2.44USD tablet
Co Quetiapine 300 mg Tablet2.44USD tablet
Jamp-Quetiapine 300 mg Tablet2.44USD tablet
Mylan-Quetiapine 300 mg Tablet2.44USD tablet
Novo-Quetiapine 300 mg Tablet2.44USD tablet
Pms-Quetiapine 300 mg Tablet2.44USD tablet
Ratio-Quetiapine 300 mg Tablet2.44USD tablet
Sandoz Quetiapine 300 mg Tablet2.44USD tablet
Apo-Quetiapine 200 mg Tablet1.67USD tablet
Co Quetiapine 200 mg Tablet1.67USD tablet
Jamp-Quetiapine 200 mg Tablet1.67USD tablet
Mylan-Quetiapine 200 mg Tablet1.67USD tablet
Novo-Quetiapine 200 mg Tablet1.67USD tablet
Pms-Quetiapine 200 mg Tablet1.67USD tablet
Ratio-Quetiapine 200 mg Tablet1.67USD tablet
Sandoz Quetiapine 200 mg Tablet1.67USD tablet
Seroquel 100 mg Tablet1.48USD tablet
Novo-Quetiapine 150 mg Tablet1.42USD tablet
Apo-Quetiapine 100 mg Tablet0.83USD tablet
Co Quetiapine 100 mg Tablet0.83USD tablet
Jamp-Quetiapine 100 mg Tablet0.83USD tablet
Mylan-Quetiapine 100 mg Tablet0.83USD tablet
Novo-Quetiapine 100 mg Tablet0.83USD tablet
Pms-Quetiapine 100 mg Tablet0.83USD tablet
Ratio-Quetiapine 100 mg Tablet0.83USD tablet
Sandoz Quetiapine 100 mg Tablet0.83USD tablet
Seroquel 25 mg Tablet0.56USD tablet
Apo-Quetiapine 25 mg Tablet0.31USD tablet
Co Quetiapine 25 mg Tablet0.31USD tablet
Jamp-Quetiapine 25 mg Tablet0.31USD tablet
Mylan-Quetiapine 25 mg Tablet0.31USD tablet
Novo-Quetiapine 25 mg Tablet0.31USD tablet
Pms-Quetiapine 25 mg Tablet0.31USD tablet
Ratio-Quetiapine 25 mg Tablet0.31USD tablet
Sandoz Quetiapine 25 mg Tablet0.31USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2251944 No2007-04-102017-05-27Canada
US4879288 No1994-09-262011-09-26Us
US5948437 Yes1997-11-282017-11-28Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityModerateNot Available
logP2.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0403 mg/mLALOGPS
logP2.93ALOGPS
logP2.81ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)15.12ChemAxon
pKa (Strongest Basic)7.06ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area48.3 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity114.09 m3·mol-1ChemAxon
Polarizability42.78 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US4879288
General References
  1. Dev V, Raniwalla J: Quetiapine: a review of its safety in the management of schizophrenia. Drug Saf. 2000 Oct;23(4):295-307. [PubMed:11051217 ]
  2. Mukaddes NM, Abali O: Quetiapine treatment of children and adolescents with Tourette's disorder. J Child Adolesc Psychopharmacol. 2003 Fall;13(3):295-9. [PubMed:14642017 ]
  3. Tallerico T, Novak G, Liu IS, Ulpian C, Seeman P: Schizophrenia: elevated mRNA for dopamine D2(Longer) receptors in frontal cortex. Brain Res Mol Brain Res. 2001 Mar 5;87(2):160-5. [PubMed:11245917 ]
  4. Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. [PubMed:18537577 ]
External Links
ATC CodesN05AH04
AHFS Codes
  • 28:16.08.04
PDB EntriesNot Available
FDA labelDownload (273 KB)
MSDSDownload (57.1 KB)
Interactions
Drug Interactions
Drug
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Quetiapine.
AclidiniumAclidinium may increase the anticholinergic activities of Quetiapine.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Quetiapine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Quetiapine.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Quetiapine.
AmisulprideThe risk or severity of adverse effects can be increased when Quetiapine is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Quetiapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Quetiapine.
AmphetamineQuetiapine may decrease the stimulatory activities of Amphetamine.
AprepitantThe serum concentration of Quetiapine can be increased when it is combined with Aprepitant.
AtazanavirThe serum concentration of Quetiapine can be increased when it is combined with Atazanavir.
AzelastineQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Quetiapine.
BenzphetamineQuetiapine may decrease the stimulatory activities of Benzphetamine.
BexaroteneThe serum concentration of Quetiapine can be decreased when it is combined with Bexarotene.
BoceprevirThe serum concentration of Quetiapine can be increased when it is combined with Boceprevir.
BosentanThe serum concentration of Quetiapine can be decreased when it is combined with Bosentan.
Botulinum Toxin Type AQuetiapine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BQuetiapine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
BromocriptineThe therapeutic efficacy of Bromocriptine can be decreased when used in combination with Quetiapine.
BuprenorphineQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Quetiapine.
ButabarbitalButabarbital may increase the hypotensive activities of Quetiapine.
ButethalButethal may increase the hypotensive activities of Quetiapine.
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Quetiapine.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Quetiapine.
CarbamazepineThe serum concentration of the active metabolites of Carbamazepine can be increased when Carbamazepine is used in combination with Quetiapine.
CathinoneQuetiapine may decrease the stimulatory activities of Cathinone.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Quetiapine.
Cimetropium BromideQuetiapine may increase the anticholinergic activities of Cimetropium Bromide.
CitalopramCitalopram may increase the QTc-prolonging activities of Quetiapine.
ClomipramineThe risk or severity of adverse effects can be increased when Clomipramine is combined with Quetiapine.
CobicistatThe serum concentration of Quetiapine can be increased when it is combined with Cobicistat.
ConivaptanThe serum concentration of Quetiapine can be increased when it is combined with Conivaptan.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Quetiapine.
DabrafenibThe serum concentration of Quetiapine can be decreased when it is combined with Dabrafenib.
DarunavirThe serum concentration of Quetiapine can be increased when it is combined with Darunavir.
DeferasiroxThe serum concentration of Quetiapine can be decreased when it is combined with Deferasirox.
DesipramineThe risk or severity of adverse effects can be increased when Desipramine is combined with Quetiapine.
DesvenlafaxineThe risk or severity of adverse effects can be increased when Desvenlafaxine is combined with Quetiapine.
DextroamphetamineQuetiapine may decrease the stimulatory activities of Dextroamphetamine.
DextromethorphanThe risk or severity of adverse effects can be increased when Dextromethorphan is combined with Quetiapine.
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Quetiapine.
DofetilideDofetilide may increase the QTc-prolonging activities of Quetiapine.
DonepezilDonepezil may increase the central neurotoxic activities of Quetiapine.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Quetiapine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
DuloxetineQuetiapine may increase the orthostatic hypotensive activities of Duloxetine.
EletriptanThe risk or severity of adverse effects can be increased when Eletriptan is combined with Quetiapine.
EluxadolineQuetiapine may increase the activities of Eluxadoline.
EnzalutamideThe serum concentration of Quetiapine can be decreased when it is combined with Enzalutamide.
Ergoloid mesylateThe risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Quetiapine.
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Quetiapine.
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Quetiapine.
EscitalopramThe risk or severity of adverse effects can be increased when Escitalopram is combined with Quetiapine.
EthanolQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Quetiapine.
FluconazoleThe metabolism of Quetiapine can be decreased when combined with Fluconazole.
FluoxetineThe risk or severity of adverse effects can be increased when Fluoxetine is combined with Quetiapine.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Quetiapine.
FosaprepitantThe serum concentration of Quetiapine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Quetiapine can be decreased when it is combined with Fosphenytoin.
FrovatriptanThe risk or severity of adverse effects can be increased when Frovatriptan is combined with Quetiapine.
Fusidic AcidThe serum concentration of Quetiapine can be increased when it is combined with Fusidic Acid.
GalantamineGalantamine may increase the central neurotoxic activities of Quetiapine.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Quetiapine.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Quetiapine.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Quetiapine.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Quetiapine is combined with Glucagon recombinant.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Quetiapine.
GoserelinGoserelin may increase the QTc-prolonging activities of Quetiapine.
HeptabarbitalHeptabarbital may increase the hypotensive activities of Quetiapine.
HexobarbitalHexobarbital may increase the hypotensive activities of Quetiapine.
HydrocodoneQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
IdelalisibThe serum concentration of Quetiapine can be increased when it is combined with Idelalisib.
ImipramineThe risk or severity of adverse effects can be increased when Imipramine is combined with Quetiapine.
IndinavirThe serum concentration of Quetiapine can be increased when it is combined with Indinavir.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Quetiapine.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Quetiapine.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Quetiapine.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Quetiapine.
Insulin HumanThe therapeutic efficacy of Insulin Regular can be decreased when used in combination with Quetiapine.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Quetiapine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Quetiapine.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Quetiapine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Quetiapine.
ItraconazoleThe serum concentration of Quetiapine can be increased when it is combined with Itraconazole.
IvabradineIvabradine may increase the QTc-prolonging activities of Quetiapine.
IvacaftorThe serum concentration of Quetiapine can be increased when it is combined with Ivacaftor.
KetoconazoleThe serum concentration of Quetiapine can be increased when it is combined with Ketoconazole.
LeuprolideLeuprolide may increase the QTc-prolonging activities of Quetiapine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Levomilnacipran is combined with Quetiapine.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Quetiapine.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Quetiapine.
LisdexamfetamineQuetiapine may decrease the stimulatory activities of Lisdexamfetamine.
LithiumLithium may increase the neurotoxic activities of Quetiapine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Quetiapine.
LorcaserinThe risk or severity of adverse effects can be increased when Lorcaserin is combined with Quetiapine.
LuliconazoleThe serum concentration of Quetiapine can be increased when it is combined with Luliconazole.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Quetiapine.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Quetiapine.
MethadoneMethadone may increase the QTc-prolonging activities of Quetiapine.
MethamphetamineQuetiapine may decrease the stimulatory activities of Methamphetamine.
MethohexitalMethohexital may increase the hypotensive activities of Quetiapine.
MethotrimeprazineQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethylphenidateThe risk or severity of adverse effects can be increased when Quetiapine is combined with Methylphenidate.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Quetiapine.
MetyrosineQuetiapine may increase the sedative activities of Metyrosine.
MifepristoneMifepristone may increase the QTc-prolonging activities of Quetiapine.
MilnacipranThe risk or severity of adverse effects can be increased when Milnacipran is combined with Quetiapine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
MitotaneThe serum concentration of Quetiapine can be decreased when it is combined with Mitotane.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Quetiapine.
MorphineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
NaratriptanThe risk or severity of adverse effects can be increased when Naratriptan is combined with Quetiapine.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Quetiapine.
NelfinavirThe serum concentration of Quetiapine can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Quetiapine can be increased when it is combined with Netupitant.
NicorandilNicorandil may increase the hypotensive activities of Quetiapine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Quetiapine.
OctreotideOctreotide may increase the QTc-prolonging activities of Quetiapine.
OrphenadrineQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PalbociclibThe serum concentration of Quetiapine can be increased when it is combined with Palbociclib.
ParaldehydeQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Paroxetine.
PentobarbitalPentobarbital may increase the hypotensive activities of Quetiapine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Quetiapine.
PhendimetrazineQuetiapine may decrease the stimulatory activities of Phendimetrazine.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Quetiapine.
PhenobarbitalThe serum concentration of Quetiapine can be decreased when it is combined with Phenobarbital.
PhentermineQuetiapine may decrease the stimulatory activities of Phentermine.
PhenytoinThe serum concentration of Quetiapine can be decreased when it is combined with Phenytoin.
PosaconazoleThe serum concentration of Quetiapine can be increased when it is combined with Posaconazole.
Potassium ChlorideQuetiapine may increase the ulcerogenic activities of Potassium Chloride.
PramlintidePramlintide may increase the anticholinergic activities of Quetiapine.
PrimidonePrimidone may increase the hypotensive activities of Quetiapine.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Quetiapine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Quetiapine.
PromethazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Quetiapine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Quetiapine.
QuinagolideThe therapeutic efficacy of Quinagolide can be decreased when used in combination with Quetiapine.
RamosetronQuetiapine may increase the activities of Ramosetron.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Quetiapine.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Quetiapine.
RifabutinThe serum concentration of Quetiapine can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Quetiapine can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Quetiapine can be decreased when it is combined with Rifapentine.
RitonavirThe serum concentration of Quetiapine can be increased when it is combined with Ritonavir.
RivastigmineRivastigmine may increase the central neurotoxic activities of Quetiapine.
RizatriptanThe risk or severity of adverse effects can be increased when Rizatriptan is combined with Quetiapine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Quetiapine.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Quetiapine.
SecobarbitalSecobarbital may increase the hypotensive activities of Quetiapine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Quetiapine.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Quetiapine.
SertralineThe risk or severity of adverse effects can be increased when Sertraline is combined with Quetiapine.
SiltuximabThe serum concentration of Quetiapine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Quetiapine can be increased when it is combined with Simeprevir.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
St. John's WortQuetiapine may increase the serotonergic activities of St. John's Wort.
StiripentolThe serum concentration of Quetiapine can be increased when it is combined with Stiripentol.
SulpirideThe risk or severity of adverse effects can be increased when Quetiapine is combined with Sulpiride.
SumatriptanThe risk or severity of adverse effects can be increased when Sumatriptan is combined with Quetiapine.
SuvorexantQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Quetiapine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Quetiapine.
TelaprevirThe serum concentration of Quetiapine can be increased when it is combined with Telaprevir.
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Quetiapine.
ThalidomideQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiotropiumQuetiapine may increase the anticholinergic activities of Tiotropium.
TocilizumabThe serum concentration of Quetiapine can be decreased when it is combined with Tocilizumab.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Quetiapine.
TopiramateThe risk or severity of adverse effects can be increased when Quetiapine is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Quetiapine.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Quetiapine.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Quetiapine.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Quetiapine.
TrimipramineThe risk or severity of adverse effects can be increased when Trimipramine is combined with Quetiapine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Quetiapine.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Quetiapine.
VenlafaxineThe risk or severity of adverse effects can be increased when Venlafaxine is combined with Quetiapine.
VilazodoneThe risk or severity of adverse effects can be increased when Vilazodone is combined with Quetiapine.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Quetiapine.
VoriconazoleThe serum concentration of Quetiapine can be increased when it is combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Quetiapine.
ZolmitriptanThe risk or severity of adverse effects can be increased when Zolmitriptan is combined with Quetiapine.
ZolpidemQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Virus receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates...
Gene Name:
HTR2A
Uniprot ID:
P28223
Molecular Weight:
52602.58 Da
References
  1. Goldstein JM: Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today (Barc). 1999 Mar;35(3):193-210. [PubMed:12973385 ]
  2. McIntyre RS, Soczynska JK, Woldeyohannes HO, Alsuwaidan M, Konarski JZ: A preclinical and clinical rationale for quetiapine in mood syndromes. Expert Opin Pharmacother. 2007 Jun;8(9):1211-9. [PubMed:17563257 ]
  3. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  4. Yatham LN, Goldstein JM, Vieta E, Bowden CL, Grunze H, Post RM, Suppes T, Calabrese JR: Atypical antipsychotics in bipolar depression: potential mechanisms of action. J Clin Psychiatry. 2005;66 Suppl 5:40-8. [PubMed:16038601 ]
  5. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Potassium channel regulator activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Gene Name:
DRD2
Uniprot ID:
P14416
Molecular Weight:
50618.91 Da
References
  1. Kapur S, Zipursky R, Jones C, Shammi CS, Remington G, Seeman P: A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry. 2000 Jun;57(6):553-9. [PubMed:10839333 ]
  2. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  3. Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. [PubMed:11873706 ]
  4. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G pro...
Gene Name:
HTR1A
Uniprot ID:
P08908
Molecular Weight:
46106.335 Da
References
  1. Ichikawa J, Li Z, Dai J, Meltzer HY: Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 2002 Nov 29;956(2):349-57. [PubMed:12445705 ]
  2. McIntyre RS, Soczynska JK, Woldeyohannes HO, Alsuwaidan M, Konarski JZ: A preclinical and clinical rationale for quetiapine in mood syndromes. Expert Opin Pharmacother. 2007 Jun;8(9):1211-9. [PubMed:17563257 ]
  3. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  4. Wood MD, Scott C, Clarke K, Cato KJ, Patel N, Heath J, Worby A, Gordon L, Campbell L, Riley G, Davies CH, Gribble A, Jones DN: Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade. CNS Neurol Disord Drug Targets. 2006 Aug;5(4):445-52. [PubMed:16918396 ]
  5. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of ...
Gene Name:
HTR1B
Uniprot ID:
P28222
Molecular Weight:
43567.535 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate c...
Gene Name:
HTR1D
Uniprot ID:
P28221
Molecular Weight:
41906.38 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Gene Name:
HTR1E
Uniprot ID:
P28566
Molecular Weight:
41681.57 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modul...
Gene Name:
HTR2C
Uniprot ID:
P28335
Molecular Weight:
51820.705 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Voltage-gated potassium channel activity
Specific Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Gene Name:
HTR3A
Uniprot ID:
P46098
Molecular Weight:
55279.835 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
other/unknown
General Function:
Serotonin receptor activity
Specific Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through...
Gene Name:
HTR6
Uniprot ID:
P50406
Molecular Weight:
46953.625 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Serotonin receptor activity
Specific Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Gene Name:
HTR7
Uniprot ID:
P34969
Molecular Weight:
53554.43 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD1
Uniprot ID:
P21728
Molecular Weight:
49292.765 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene Name:
DRD5
Uniprot ID:
P21918
Molecular Weight:
52950.5 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled amine receptor activity
Specific Function:
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Gene Name:
DRD3
Uniprot ID:
P35462
Molecular Weight:
44224.335 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Sh3 domain binding
Specific Function:
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
Gene Name:
DRD4
Uniprot ID:
P21917
Molecular Weight:
48359.86 Da
References
  1. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1A
Uniprot ID:
P35348
Molecular Weight:
51486.005 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Alpha1-adrenergic receptor activity
Specific Function:
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Gene Name:
ADRA1D
Uniprot ID:
P25100
Molecular Weight:
60462.205 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Thioesterase binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianser...
Gene Name:
ADRA2A
Uniprot ID:
P08913
Molecular Weight:
48956.275 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Epinephrine binding
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phent...
Gene Name:
ADRA2B
Uniprot ID:
P18089
Molecular Weight:
49565.8 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Protein homodimerization activity
Specific Function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2C
Uniprot ID:
P18825
Molecular Weight:
49521.585 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM1
Uniprot ID:
P11229
Molecular Weight:
51420.375 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled acetylcholine receptor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then trigge...
Gene Name:
CHRM2
Uniprot ID:
P08172
Molecular Weight:
51714.605 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Receptor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM3
Uniprot ID:
P20309
Molecular Weight:
66127.445 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Guanyl-nucleotide exchange factor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Gene Name:
CHRM4
Uniprot ID:
P08173
Molecular Weight:
53048.65 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM5
Uniprot ID:
P08912
Molecular Weight:
60073.205 Da
References
  1. Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. [PubMed:11132243 ]
  2. Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. [PubMed:17848919 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Urichuk L, Prior TI, Dursun S, Baker G: Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. [PubMed:18537577 ]
  2. DeVane CL, Nemeroff CB: Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. Clin Pharmacokinet. 2001;40(7):509-22. [PubMed:11510628 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. [PubMed:12031686 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on May 27, 2016 03:27