Pharmacokinetics of single oral doses of nortriptyline in depressed elderly hospital patients and young healthy volunteers.

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Dawling S, Crome P, Braithwaite R

Pharmacokinetics of single oral doses of nortriptyline in depressed elderly hospital patients and young healthy volunteers.

Clin Pharmacokinet. 1980 Jul-Aug;5(4):394-401. doi: 10.2165/00003088-198005040-00007.

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6994983 [ View in PubMed
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Abstract

A single oral dose of 75mg nortriptyline was given to a group of 20 depressed elderly patients in hospital. Subsequent plasma nortriptyline concentrations were used to calculate the half-life and clearance of the drug. These measurements were compared with those made previously in 17 healthy young volunteer subjects. Plasma nortriptyline half-life was longer and clearance slower (p < 0.002) in the elderly group than in the volunteers. There was no correlation of age with either of these parameters within the 2 groups, and no differences in nortriptyline pharmacokinetics could be detected between the male and female volunteer subjects. The possible reasons for these findings and their clinical consequences are discussed.

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