Interaction of cimetidine with human serum albumin.
Article Details
- CitationCopy to clipboard
Wilson CJ, Bogoyevitch MA, Winzor DJ
Interaction of cimetidine with human serum albumin.
Biochem Pharmacol. 1990 Oct 1;40(7):1672-3. doi: 10.1016/0006-2952(90)90472-w.
- PubMed ID
- 2222522 [ View in PubMed]
- Abstract
Ultrafiltration studies have detected the existence of a weak interaction between cimetidine and human serum albumin, a finding supported by corresponding studies with this xenobiotic and bovine serum albumin. Furthermore, the binding characteristics of the interaction with human serum albumin (4 sites, K = 630 M-1) more than suffice to account for the proportion of protein-bound drug in the serum of patients subjected to cimetidine therapy. Thus, although alpha 1-acid glycoprotein is usually regarded as the specific transporter of basic drugs, the present evidence implicates albumin as the likely binding protein for cimetidine in serum.
DrugBank Data that Cites this Article
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Cimetidine Serum albumin Protein Humans UnknownSubstrateDetails