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Identification
NameCimetidine
Accession NumberDB00501  (APRD00568)
TypeSmall Molecule
GroupsApproved
DescriptionA histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]
Structure
Thumb
Synonyms
1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine
2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine
Cimetag
Cimetidin
Cimetidina
Cimétidine
Cimetidinum
N-Cyano-n'-methyl-n''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine
N''-cyano-N-methyl-n'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine
Tagamet hb 200
Ulcerfen
External Identifiers
  • SKF 92334
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cimetidine 200 Tab 200mgtablet200 mgoralPro Doc Limitee1984-12-312009-07-23Canada
Cimetidine Tab 300mgtablet300 mgoralPro Doc Limitee1983-12-312010-07-13Canada
Cimetidine Tab 400mgtablet400 mgoralPro Doc Limitee1984-12-312009-07-23Canada
Cimetidine Tab 600mgtablet600 mgoralPro Doc Limitee1984-12-312012-07-23Canada
Dom-cimetidinetablet600 mgoralDominion Pharmacal2000-06-19Not applicableCanada
Dom-cimetidinetablet800 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-cimetidinetablet300 mgoralDominion Pharmacal2000-06-19Not applicableCanada
Dom-cimetidinetablet200 mgoralDominion PharmacalNot applicableNot applicableCanada
Dom-cimetidinetablet400 mgoralDominion Pharmacal2000-06-19Not applicableCanada
Gen-cimetidine Tablets 200mgtablet200 mgoralGenpharm Ulc1997-05-302009-08-05Canada
Mylan-cimetidinetablet300 mgoralMylan Pharmaceuticals Ulc1997-05-30Not applicableCanada
Mylan-cimetidinetablet400 mgoralMylan Pharmaceuticals Ulc1997-05-30Not applicableCanada
Mylan-cimetidinetablet600 mgoralMylan Pharmaceuticals Ulc1997-05-30Not applicableCanada
Mylan-cimetidinetablet800 mgoralMylan Pharmaceuticals Ulc1997-05-30Not applicableCanada
Novo-cimetinetablet600 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Novo-cimetinetablet800 mgoralTeva Canada Limited1987-12-31Not applicableCanada
Novo-cimetinetablet200 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Novo-cimetinetablet300 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Novo-cimetinetablet400 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Novo-cimetine Injectionsolution150 mgintramuscular; intravenousTeva Canada Limited1997-09-022015-04-30Canada
Nu-cimet Tab 200mgtablet200 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-cimet Tab 300mgtablet300 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-cimet Tab 400mgtablet400 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-cimet Tab 600mgtablet600 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Peptol Tab 200mgtablet200 mgoralCarter Horner Corp.1981-12-312004-07-09Canada
Peptol Tab 300mgtablet300 mgoralCarter Horner Corp.1981-12-312004-07-09Canada
Peptol Tab 400mgtablet400 mgoralCarter Horner Corp.1982-12-312004-07-09Canada
Peptol Tab 600mgtablet600 mgoralCarter Horner Corp.1983-12-312004-07-09Canada
Peptol Tab 800mgtablet800 mgoralCarter Horner Corp.1984-12-312004-07-09Canada
PMS-cimetidinetablet600 mgoralPharmascience Inc1998-02-05Not applicableCanada
PMS-cimetidinetablet200 mgoralPharmascience Inc1998-02-05Not applicableCanada
PMS-cimetidinetablet800 mgoralPharmascience Inc1998-02-05Not applicableCanada
PMS-cimetidinetablet300 mgoralPharmascience Inc1998-02-05Not applicableCanada
PMS-cimetidinetablet400 mgoralPharmascience Inc1998-02-05Not applicableCanada
Tagamet 300tablet300 mgoralGlaxosmithkline Inc1992-12-312002-02-04Canada
Tagamet 400tablet400 mgoralGlaxosmithkline Inc1993-12-312002-02-04Canada
Tagamet 600tablet600 mgoralGlaxosmithkline Inc1992-12-312002-02-04Canada
Tagamet Infusion 6mg/mlliquid6 mgintravenousSmithkline Beecham Pharma Division Of Smithkline Beecham Inc1992-12-311999-03-24Canada
Tagamet Inj 150mg/mlliquid150 mgintramuscular; intravenousSmithkline Beecham Pharma Division Of Smithkline Beecham Inc1995-12-311998-08-31Canada
Tagamet Liq 300mg/5mlliquid300 mgoralSmith Kline & French Canada Ltd.1982-12-311997-08-15Canada
Tagamet Liquid 60mg/mlliquid60 mgoralGlaxosmithkline Inc1993-12-312002-07-31Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Cimetidine Tab 200mgtablet200 mgoralApotex Inc1982-12-31Not applicableCanada
Apo Cimetidine Tab 300mgtablet300 mgoralApotex Inc1982-12-31Not applicableCanada
Apo Cimetidine Tab 400mgtablet400 mgoralApotex Inc1983-12-31Not applicableCanada
Apo Cimetidine Tab 600mgtablet600 mgoralApotex Inc1983-12-31Not applicableCanada
Apo-cimetidine Oral Solutionliquid300 mgoralApotex Inc2001-01-05Not applicableCanada
Apo-cimetidine Tab 800mgtablet800 mgoralApotex Inc1988-12-31Not applicableCanada
Cimetidinetablet400 mg/1oralLiberty Pharmaceuticals, Inc.2010-11-24Not applicableUs
Cimetidinetablet, film coated800 mg/1oralPhysicians Total Care, Inc.1994-05-23Not applicableUs
Cimetidinetablet, film coated300 mg/1oralTeva Pharmaceuticals USA Inc2003-11-24Not applicableUs
Cimetidinetablet, film coated400 mg/1oralDispensing Solutions, Inc.2010-05-26Not applicableUs
Cimetidinetablet400 mg/1oralREMEDYREPACK INC.2010-11-24Not applicableUs
Cimetidinetablet, film coated400 mg/1oralSTAT Rx USA LLC2010-05-26Not applicableUs
Cimetidinetablet, film coated800 mg/1oralbryant ranch prepack2003-12-06Not applicableUs
Cimetidinetablet, film coated300 mg/1oralMylan Pharmaceuticals Inc.1994-05-17Not applicableUs
Cimetidinetablet, film coated400 mg/1oralPreferred Pharmaceuticals, Inc2011-07-06Not applicableUs
Cimetidinetablet, film coated300 mg/1oralREMEDYREPACK INC.2014-08-01Not applicableUs
Cimetidinetablet, film coated400 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Cimetidinetablet, film coated400 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Cimetidinetablet400 mg/1oralREMEDYREPACK INC.2011-07-14Not applicableUs
Cimetidinetablet, film coated400 mg/1oralTeva Pharmaceuticals USA Inc2004-02-02Not applicableUs
Cimetidinetablet, film coated200 mg/1oralCarilion Materials Management1994-05-17Not applicableUs
Cimetidinetablet, film coated800 mg/1oralSTAT Rx USA LLC2010-05-26Not applicableUs
Cimetidinetablet, film coated300 mg/1oralA S Medication Solutions2003-11-24Not applicableUs
Cimetidinetablet, film coated400 mg/1oralbryant ranch prepack2010-10-01Not applicableUs
Cimetidinetablet, film coated400 mg/1oralMylan Pharmaceuticals Inc.1994-05-17Not applicableUs
Cimetidinetablet, film coated300 mg/1oralAv Kare, Inc.2016-01-12Not applicableUs
Cimetidinetablet, film coated300 mg/1oralPhysicians Total Care, Inc.1994-06-22Not applicableUs
Cimetidinetablet, film coated300 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Cimetidinetablet, film coated800 mg/1oralTeva Pharmaceuticals USA Inc2003-12-06Not applicableUs
Cimetidinetablet, film coated300 mg/1oralCarilion Materials Management2003-11-24Not applicableUs
Cimetidinetablet, film coated400 mg/1oralAidarex Pharmaceuticals LLC2004-02-02Not applicableUs
Cimetidinetablet, film coated400 mg/1oralA S Medication Solutions2004-02-02Not applicableUs
Cimetidinetablet, film coated300 mg/1oralbryant ranch prepack2003-11-24Not applicableUs
Cimetidinetablet, film coated800 mg/1oralMylan Pharmaceuticals Inc.1994-05-17Not applicableUs
Cimetidinetablet, film coated400 mg/1oralPhysicians Total Care, Inc.1994-07-25Not applicableUs
Cimetidinetablet, film coated300 mg/1oralSTAT Rx USA LLC1994-05-17Not applicableUs
Cimetidinetablet, film coated400 mg/1oralProficient Rx LP2004-02-02Not applicableUs
Cimetidinetablet, film coated200 mg/1oralMylan Pharmaceuticals Inc.1994-05-17Not applicableUs
Cimetidinetablet, film coated400 mg/1oralCarilion Materials Management2004-02-02Not applicableUs
Cimetidinetablet, film coated300 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Cimetidinetablet, film coated400 mg/1oralAv Kare, Inc.2013-07-23Not applicableUs
Cimetidine Hydrochloridesolution300 mg/5mLoralMorton Grove Pharmaceuticals, Inc.1997-03-12Not applicableUs
Cimetidine Hydrochloride Oral Solutionsolution300 mg/5mLoralHi Tech Pharmacal Co., Inc.1997-10-28Not applicableUs
Good Sense Heartburn Relieftablet200 mg/1oralbryant ranch prepack2002-12-30Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acid Reducertablet200 mg/1oralKroger Company2015-10-21Not applicableUs
Acid Reducertablet200 mg/1oralRite Aid Corporation2005-07-08Not applicableUs
Cimetidine Acid Reducertablet200 mg/1oralWalgreen Company2001-03-27Not applicableUs
Dg Health Heartburn Relieftablet200 mg/1oralDolgencorp, LLC2010-03-02Not applicableUs
Equaline Acid Reducertablet200 mg/1oralSupervalu Inc2004-09-15Not applicableUs
Equate Cimetidinetablet200 mg/1oralWal Mart Stores Inc2006-09-27Not applicableUs
Gaviscon All-nighttablet100 mgoralGlaxosmithkline Consumer Healthcare Inc.Not applicableNot applicableCanada
Gaviscon Preventtablet100 mgoralGlaxosmithkline Consumer Healthcare Inc.1998-08-172002-07-31Canada
Gaviscon Prevent Extra Strengthtablet200 mgoralGlaxosmithkline Consumer Healthcare Inc.Not applicableNot applicableCanada
Good Neighbor Pharmacy Heartburn Relieftablet200 mg/1oralAmerisource Bergen2000-01-05Not applicableUs
Good Sense Heartburn Relieftablet200 mg/1oralL. Perrigo Company2002-12-30Not applicableUs
Harris Teeter Acid Reducertablet200 mg/1oralHarris Teeter, LLC2015-03-30Not applicableUs
Heartburn Relieftablet200 mg/1oralCVS Pharmacy2000-01-14Not applicableUs
Heartburn Relieftablet200 mg/1oralMeijer Distribution Inc2000-01-05Not applicableUs
Heartburn Relieftablet200 mg/1oralFamily Dollar Services Inc2000-09-18Not applicableUs
Leader Heartburn Relieftablet200 mg/1oralCardinal Health2000-02-04Not applicableUs
Smart Sense Acid Reducertablet200 mg/1oralKmart Corporation2000-01-06Not applicableUs
Sunmark Heartburn Relief Acid Reducertablet200 mg/1oralMc Kesson2003-09-19Not applicableUs
Tagamettablet200 mg/1oralMedtech Products Inc.2012-06-01Not applicableUs
Topcare Heartburn Relieftablet200 mg/1oralTopco Associates LLC2000-02-22Not applicableUs
Up and Up Acid Reducertablet200 mg/1oralTarget Corporation2010-05-12Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
CimetagJulphar
Tagamet HB200GlaxoSmithKline
UlcedineNot Available
UlcerfenFinadiet
UlcimetFarmasa
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Cimetidine Hydrochloride
70059-30-2
Thumb
  • InChI Key: QJHCNBWLPSXHBL-UHFFFAOYSA-N
  • Monoisotopic Mass: 288.092392971
  • Average Mass: 288.8
DBSALT000287
Categories
UNII80061L1WGD
CAS number51481-61-9
WeightAverage: 252.339
Monoisotopic: 252.115715232
Chemical FormulaC10H16N6S
InChI KeyInChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N
InChI
InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)
IUPAC Name
(Z)-1-cyano-2-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
SMILES
C\N=C(\NCCSCC1=C(C)NC=N1)NC#N
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as imidazoles. These are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassImidazoles
Direct ParentImidazoles
Alternative Parents
Substituents
  • Heteroaromatic compound
  • Imidazole
  • Guanidine
  • Azacycle
  • Dialkylthioether
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Sulfenyl compound
  • Carboximidamide
  • Thioether
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Imine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
PharmacodynamicsCimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Mechanism of actionCimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Related Articles
AbsorptionRapid 60-70%
Volume of distributionNot Available
Protein binding15-20%
Metabolism

Hepatic

Route of eliminationThe principal route of excretion of cimetidine is the urine.
Half life2 hours
ClearanceNot Available
ToxicitySymptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Cimetidine Action PathwayDrug actionSMP00232
Cimetidine Metabolism PathwayDrug metabolismSMP00617
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9855
Blood Brain Barrier-0.6782
Caco-2 permeable-0.6358
P-glycoprotein substrateSubstrate0.7887
P-glycoprotein inhibitor INon-inhibitor0.8781
P-glycoprotein inhibitor IINon-inhibitor0.8382
Renal organic cation transporterInhibitor0.7233
CYP450 2C9 substrateNon-substrate0.8048
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5795
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorInhibitor0.5773
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9575
Ames testNon AMES toxic0.837
CarcinogenicityNon-carcinogens0.9579
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7341 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7983
hERG inhibition (predictor II)Non-inhibitor0.8745
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Glaxosmithkline
  • Apotex inc
  • Contract pharmacal corp
  • Dava pharmaceuticals inc
  • Endo pharmaceuticals inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lek pharmaceuticals d d
  • Mylan pharmaceuticals inc
  • L perrigo co
  • Perrigo co
  • Pliva inc
  • Roxane laboratories inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
  • Hospira inc
  • Luitpold pharmaceuticals inc
  • Teva parenteral medicines inc
  • Actavis mid atlantic llc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Hi tech pharmacal co inc
  • Novex pharma
  • Pharmaceutical assoc inc div beach products
  • Teva pharmaceuticals usa
  • Wockhardt eu operations (swiss) ag
Packagers
Dosage forms
FormRouteStrength
Liquidoral300 mg
Tabletoral400 mg/1
Tablet, film coatedoral200 mg/1
Tablet, film coatedoral300 mg/1
Tablet, film coatedoral400 mg/1
Tablet, film coatedoral800 mg/1
Solutionoral300 mg/5mL
Tabletoral100 mg
Tabletoral200 mg/1
Tabletoral300 mg
Tabletoral400 mg
Tabletoral600 mg
Tabletoral800 mg
Solutionintramuscular; intravenous150 mg
Tabletoral200 mg
Liquidintravenous6 mg
Liquidintramuscular; intravenous150 mg
Liquidoral60 mg
Prices
Unit descriptionCostUnit
Cimetidine 800 mg tablet2.7USD tablet
Tagamet 400 mg tablet2.51USD tablet
Cimetidine 150 mg/ml vial1.67USD ml
Cimetidine powder1.48USD g
Cimetidine 400 mg tablet1.44USD tablet
Tagamet 300 mg tablet1.28USD tablet
Cimetidine 300 mg tablet0.93USD tablet
Cimetidine 200 mg tablet0.46USD tablet
Cimetidine HCl 300 mg/5ml Solution0.38USD ml
Tagamet hb 200 mg tablet0.37USD tablet
Apo-Cimetidine 800 mg Tablet0.27USD tablet
Mylan-Cimetidine 800 mg Tablet0.27USD tablet
Acid reducer 200 mg tablet0.21USD tablet
Apo-Cimetidine 600 mg Tablet0.18USD tablet
Mylan-Cimetidine 600 mg Tablet0.18USD tablet
Novo-Cimetine 600 mg Tablet0.18USD tablet
Nu-Cimet 600 mg Tablet0.18USD tablet
Apo-Cimetidine 400 mg Tablet0.14USD tablet
Mylan-Cimetidine 400 mg Tablet0.14USD tablet
Novo-Cimetine 400 mg Tablet0.14USD tablet
Nu-Cimet 400 mg Tablet0.14USD tablet
Apo-Cimetidine 200 mg Tablet0.09USD tablet
Apo-Cimetidine 300 mg Tablet0.09USD tablet
Mylan-Cimetidine 300 mg Tablet0.09USD tablet
Novo-Cimetine 300 mg Tablet0.09USD tablet
Nu-Cimet 300 mg Tablet0.09USD tablet
Heartburn relief 200 mg tablet0.08USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142 °CPhysProp
water solubility9380 mg/L (at 25 °C)MCFARLAND,JW ET AL. (2001)
logP0.40HANSCH,C ET AL. (1995)
logS-1.35ADME Research, USCD
Caco2 permeability-5.89ADME Research, USCD
pKa6.8TOMLINSON,E & HAFKENSCHEID,TL (1986)
Predicted Properties
PropertyValueSource
Water Solubility0.816 mg/mLALOGPS
logP0.44ALOGPS
logP-0.11ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)13.38ChemAxon
pKa (Strongest Basic)6.91ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area88.89 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity70.32 m3·mol-1ChemAxon
Polarizability27.47 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (10 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-002b-9510000000-36ce01132725fd5bf5d8View in MoNA
1D NMR1H NMR SpectrumNot Available
References
Synthesis Reference

Saburo Uchikuga, Tomoyasu Tashiro, Yasuko Osawa, “Process for preparing the H.sub.2 -receptor antagonist cimetidine.” U.S. Patent US4413129, issued March, 1972.

US4413129
General References
  1. Michnovicz JJ, Galbraith RA: Cimetidine inhibits catechol estrogen metabolism in women. Metabolism. 1991 Feb;40(2):170-4. [PubMed:1988774 ]
External Links
ATC CodesA02BA01A02BA51
AHFS Codes
  • 56:28.12
PDB EntriesNot Available
FDA labelDownload (420 KB)
MSDSDownload (73.4 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Cimetidine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Cimetidine.
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Cimetidine.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Cimetidine.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Cimetidine.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Cimetidine.
AcetaminophenThe serum concentration of Cimetidine can be increased when it is combined with Acetaminophen.
AcetohexamideThe serum concentration of Acetohexamide can be increased when it is combined with Cimetidine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Cimetidine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Cimetidine.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Cimetidine.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Cimetidine.
AfatinibThe serum concentration of Cimetidine can be increased when it is combined with Afatinib.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Cimetidine.
AlbendazoleThe serum concentration of Cimetidine can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Cimetidine.
AlectinibThe serum concentration of Cimetidine can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Cimetidine.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Cimetidine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Cimetidine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Cimetidine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Cimetidine.
AmantadineThe serum concentration of Cimetidine can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Cimetidine.
AmineptineThe metabolism of Amineptine can be decreased when combined with Cimetidine.
Aminohippuric acidThe serum concentration of Cimetidine can be increased when it is combined with Aminohippuric acid.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Cimetidine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Cimetidine.
AmiodaroneThe serum concentration of Cimetidine can be decreased when it is combined with Amiodarone.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Cimetidine.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Cimetidine.
AmitriptylineThe serum concentration of Cimetidine can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Cimetidine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Cimetidine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Cimetidine.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Cimetidine.
AmphetamineAmphetamine may decrease the sedative activities of Cimetidine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Cimetidine.
AmprenavirThe serum concentration of Cimetidine can be decreased when it is combined with Amprenavir.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Cimetidine.
AmrinoneThe serum concentration of Amrinone can be increased when it is combined with Cimetidine.
AmsacrineThe serum concentration of Cimetidine can be increased when it is combined with Amsacrine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Cimetidine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Cimetidine.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Cimetidine.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Cimetidine.
AprindineThe metabolism of Aprindine can be decreased when combined with Cimetidine.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Cimetidine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Cimetidine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Cimetidine.
ArtemetherThe metabolism of Artemether can be decreased when combined with Cimetidine.
AstemizoleThe serum concentration of Cimetidine can be increased when it is combined with Astemizole.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Cimetidine.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Cimetidine.
AtazanavirThe serum concentration of Cimetidine can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Cimetidine.
AtenololThe serum concentration of Cimetidine can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Cimetidine.
AtorvastatinThe risk or severity of adverse effects can be increased when Atorvastatin is combined with Cimetidine.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Cimetidine.
AzelastineThe serum concentration of Cimetidine can be increased when it is combined with Azelastine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Cimetidine.
AzelnidipineThe serum concentration of Azelnidipine can be increased when it is combined with Cimetidine.
AzimilideThe serum concentration of Azimilide can be increased when it is combined with Cimetidine.
AzithromycinThe serum concentration of Cimetidine can be increased when it is combined with Azithromycin.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Cimetidine.
BenidipineThe serum concentration of Benidipine can be increased when it is combined with Cimetidine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Cimetidine.
BenzocaineThe serum concentration of Cimetidine can be increased when it is combined with Benzocaine.
BenzphetamineBenzphetamine may decrease the sedative activities of Cimetidine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Cimetidine.
Benzylpenicilloyl PolylysineCimetidine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BepridilThe serum concentration of Cimetidine can be increased when it is combined with Bepridil.
BepridilThe metabolism of Bepridil can be decreased when combined with Cimetidine.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Cimetidine.
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Cimetidine.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Cimetidine.
BiperidenThe serum concentration of Cimetidine can be increased when it is combined with Biperiden.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Cimetidine.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Cimetidine.
BortezomibThe metabolism of Bortezomib can be decreased when combined with Cimetidine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Cimetidine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Cimetidine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Cimetidine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Cimetidine.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Cimetidine.
BromocriptineThe serum concentration of Cimetidine can be increased when it is combined with Bromocriptine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Cimetidine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Cimetidine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Cimetidine.
BuprenorphineThe serum concentration of Cimetidine can be increased when it is combined with Buprenorphine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Cimetidine.
BupropionThe serum concentration of Cimetidine can be increased when it is combined with Bupropion.
BupropionThe metabolism of Bupropion can be decreased when combined with Cimetidine.
BuspironeThe serum concentration of Cimetidine can be increased when it is combined with Buspirone.
BuspironeThe metabolism of Buspirone can be decreased when combined with Cimetidine.
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Cimetidine.
CabazitaxelThe serum concentration of Cimetidine can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Cimetidine.
CaffeineThe serum concentration of Cimetidine can be increased when it is combined with Caffeine.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Cimetidine.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Cimetidine.
CanagliflozinThe serum concentration of Cimetidine can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Cimetidine can be increased when it is combined with Candesartan.
CapecitabineThe serum concentration of the active metabolites of Capecitabine can be increased when Capecitabine is used in combination with Cimetidine.
CaptoprilThe serum concentration of Cimetidine can be increased when it is combined with Captopril.
CaptoprilThe metabolism of Captopril can be decreased when combined with Cimetidine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Cimetidine.
CarbamazepineThe serum concentration of Cimetidine can be decreased when it is combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Cimetidine.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Cimetidine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Cimetidine.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Cimetidine.
CarmustineCimetidine may increase the myelosuppressive activities of Carmustine.
CarteololThe metabolism of Carteolol can be decreased when combined with Cimetidine.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Cimetidine.
CaspofunginThe serum concentration of Cimetidine can be increased when it is combined with Caspofungin.
CefditorenThe serum concentration of Cefditoren can be decreased when it is combined with Cimetidine.
CefpodoximeCimetidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
CefuroximeCimetidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Cimetidine.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Cimetidine.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Cimetidine.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Cimetidine.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Cimetidine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Cimetidine.
ChloroquineThe serum concentration of Cimetidine can be increased when it is combined with Chloroquine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Cimetidine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Cimetidine.
ChlorphentermineChlorphentermine may decrease the sedative activities of Cimetidine.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Cimetidine.
ChlorpromazineThe serum concentration of Cimetidine can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Chlorpropamide can be increased when it is combined with Cimetidine.
ChlorprothixeneThe serum concentration of Cimetidine can be increased when it is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Cimetidine.
CholesterolThe serum concentration of Cimetidine can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Cimetidine can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Cimetidine can be increased when it is combined with Cilazapril.
CilnidipineThe serum concentration of Cilnidipine can be increased when it is combined with Cimetidine.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Cimetidine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Cimetidine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Cimetidine can be increased when it is combined with Ciprofloxacin.
CisaprideThe metabolism of Cisapride can be decreased when combined with Cimetidine.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Cimetidine.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Cimetidine.
CitalopramThe serum concentration of Cimetidine can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Cimetidine.
ClarithromycinThe serum concentration of Cimetidine can be increased when it is combined with Clarithromycin.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Cimetidine.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Cimetidine.
ClofazimineThe serum concentration of Cimetidine can be increased when it is combined with Clofazimine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Cimetidine.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Cimetidine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Cimetidine.
ClomipramineThe serum concentration of Cimetidine can be increased when it is combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Cimetidine.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Cimetidine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Cimetidine.
ClotrimazoleThe serum concentration of Cimetidine can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Cimetidine.
CobicistatThe serum concentration of Cimetidine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Cimetidine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Cimetidine.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Cimetidine.
ColchicineThe serum concentration of Cimetidine can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Cimetidine can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Cimetidine.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Cimetidine.
CrizotinibThe serum concentration of Cimetidine can be increased when it is combined with Crizotinib.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Cimetidine.
CyclophosphamideThe serum concentration of Cimetidine can be increased when it is combined with Cyclophosphamide.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Cimetidine.
CyclosporineThe serum concentration of Cimetidine can be decreased when it is combined with Cyclosporine.
CysteamineThe therapeutic efficacy of Cysteamine can be decreased when used in combination with Cimetidine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Cimetidine.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Cimetidine.
DaclatasvirThe serum concentration of Cimetidine can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Cimetidine.
DactinomycinThe serum concentration of Cimetidine can be increased when it is combined with Dactinomycin.
DalfampridineThe serum concentration of Dalfampridine can be increased when it is combined with Cimetidine.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Cimetidine.
DapoxetineThe metabolism of Dapoxetine can be decreased when combined with Cimetidine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Cimetidine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Cimetidine.
DarodipineThe serum concentration of Darodipine can be increased when it is combined with Cimetidine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Cimetidine.
DasatinibCimetidine can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
DasatinibThe serum concentration of Cimetidine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Cimetidine.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Cimetidine.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Cimetidine.
DesipramineThe metabolism of Desipramine can be decreased when combined with Cimetidine.
DesipramineThe serum concentration of Cimetidine can be increased when it is combined with Desipramine.
DesloratadineThe serum concentration of Cimetidine can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Cimetidine can be decreased when it is combined with Dexamethasone.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Cimetidine.
DexmethylphenidateCimetidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Cimetidine.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Cimetidine.
DextromethorphanThe serum concentration of Cimetidine can be increased when it is combined with Dextromethorphan.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Cimetidine.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Cimetidine.
DiclofenacThe serum concentration of Cimetidine can be increased when it is combined with Diclofenac.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Cimetidine.
DicoumarolCimetidine may increase the anticoagulant activities of Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Cimetidine.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Cimetidine.
DigoxinThe serum concentration of Cimetidine can be decreased when it is combined with Digoxin.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Cimetidine.
DihydroergotamineThe serum concentration of Cimetidine can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Cimetidine.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Cimetidine.
DiltiazemThe serum concentration of Cimetidine can be increased when it is combined with Diltiazem.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Cimetidine.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Cimetidine.
DipyridamoleThe serum concentration of Cimetidine can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Cimetidine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Cimetidine.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Cimetidine.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Cimetidine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Cimetidine.
DopamineThe metabolism of Dopamine can be decreased when combined with Cimetidine.
DosulepinThe metabolism of Dosulepin can be decreased when combined with Cimetidine.
DotarizineThe serum concentration of Dotarizine can be increased when it is combined with Cimetidine.
DoxazosinThe serum concentration of Cimetidine can be increased when it is combined with Doxazosin.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Cimetidine.
DoxepinThe metabolism of Doxepin can be decreased when combined with Cimetidine.
DoxepinThe serum concentration of Cimetidine can be increased when it is combined with Doxepin.
DoxofyllineThe serum concentration of Doxofylline can be increased when it is combined with Cimetidine.
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Cimetidine.
DronabinolThe serum concentration of Cimetidine can be increased when it is combined with Dronabinol.
DronabinolThe metabolism of Dronabinol can be decreased when combined with Cimetidine.
DronedaroneThe serum concentration of Cimetidine can be increased when it is combined with Dronedarone.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Cimetidine.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Cimetidine.
DyphyllineThe metabolism of Dyphylline can be decreased when combined with Cimetidine.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Cimetidine.
EfonidipineThe serum concentration of Efonidipine can be increased when it is combined with Cimetidine.
ElbasvirThe serum concentration of Cimetidine can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Cimetidine.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Cimetidine.
EnalaprilThe serum concentration of Cimetidine can be increased when it is combined with Enalapril.
EncainideThe metabolism of Encainide can be decreased when combined with Cimetidine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Cimetidine.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Cimetidine.
EnzalutamideThe serum concentration of Cimetidine can be increased when it is combined with Enzalutamide.
EperisoneThe serum concentration of Eperisone can be increased when it is combined with Cimetidine.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Cimetidine.
EpirubicinThe serum concentration of Epirubicin can be increased when it is combined with Cimetidine.
ErgonovineThe serum concentration of Cimetidine can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Cimetidine can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Cimetidine.
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Cimetidine.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Cimetidine.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Cimetidine.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Cimetidine.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Cimetidine.
EstramustineThe serum concentration of Cimetidine can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Estriol can be decreased when it is combined with Cimetidine.
EstroneThe serum concentration of Estrone can be decreased when it is combined with Cimetidine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Cimetidine.
Ethyl biscoumacetateCimetidine may increase the anticoagulant activities of Ethyl biscoumacetate.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Cimetidine.
EtoperidoneThe metabolism of Etoperidone can be decreased when combined with Cimetidine.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Cimetidine.
EtoposideThe serum concentration of Cimetidine can be increased when it is combined with Etoposide.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Cimetidine.
EtravirineThe serum concentration of Cimetidine can be increased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Cimetidine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Cimetidine.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Cimetidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Cimetidine.
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Cimetidine.
FendilineThe serum concentration of Fendiline can be increased when it is combined with Cimetidine.
FenfluramineThe metabolism of Fenfluramine can be decreased when combined with Cimetidine.
FentanylThe serum concentration of Cimetidine can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Cimetidine.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Cimetidine.
FexofenadineThe serum concentration of Cimetidine can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Cimetidine.
FidaxomicinThe serum concentration of Cimetidine can be increased when it is combined with Fidaxomicin.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Cimetidine.
FlecainideThe metabolism of Flecainide can be decreased when combined with Cimetidine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Cimetidine.
FloxuridineThe serum concentration of the active metabolites of Floxuridine can be increased when Floxuridine is used in combination with Cimetidine.
FluconazoleThe serum concentration of Cimetidine can be increased when it is combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Cimetidine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Cimetidine.
FluorouracilThe serum concentration of Fluorouracil can be increased when it is combined with Cimetidine.
FluoxetineThe serum concentration of Cimetidine can be increased when it is combined with Fluoxetine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Cimetidine.
FlupentixolThe serum concentration of Cimetidine can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Cimetidine can be increased when it is combined with Fluphenazine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Cimetidine.
FlurazepamThe serum concentration of Cimetidine can be increased when it is combined with Flurazepam.
FlutamideThe metabolism of Flutamide can be decreased when combined with Cimetidine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Cimetidine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Cimetidine.
FluvoxamineThe serum concentration of Cimetidine can be increased when it is combined with Fluvoxamine.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Cimetidine.
FormoterolThe metabolism of Formoterol can be decreased when combined with Cimetidine.
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Cimetidine.
FosphenytoinThe metabolism of Fosphenytoin can be decreased when combined with Cimetidine.
GabapentinThe serum concentration of Gabapentin can be increased when it is combined with Cimetidine.
GalantamineThe metabolism of Galantamine can be decreased when combined with Cimetidine.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Cimetidine.
GefitinibThe serum concentration of Cimetidine can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Cimetidine.
GenisteinThe serum concentration of Cimetidine can be increased when it is combined with Genistein.
GlibornurideThe serum concentration of Glibornuride can be increased when it is combined with Cimetidine.
GliclazideThe serum concentration of Gliclazide can be increased when it is combined with Cimetidine.
GlimepirideThe serum concentration of Glimepiride can be increased when it is combined with Cimetidine.
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Cimetidine.
GliquidoneThe serum concentration of Gliquidone can be increased when it is combined with Cimetidine.
GlisoxepideThe serum concentration of Glisoxepide can be increased when it is combined with Cimetidine.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Cimetidine.
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Cimetidine.
GlycerolThe serum concentration of Cimetidine can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Cimetidine can be increased when it is combined with Gramicidin D.
GranisetronThe metabolism of Granisetron can be decreased when combined with Cimetidine.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Cimetidine.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Cimetidine.
GrepafloxacinThe serum concentration of Cimetidine can be increased when it is combined with Grepafloxacin.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Cimetidine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Cimetidine.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Cimetidine.
HaloperidolThe serum concentration of Cimetidine can be increased when it is combined with Haloperidol.
HalothaneThe metabolism of Halothane can be decreased when combined with Cimetidine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Cimetidine.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Cimetidine.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Cimetidine.
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Cimetidine.
HydrocortisoneThe serum concentration of Cimetidine can be increased when it is combined with Hydrocortisone.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Cimetidine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Cimetidine.
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Cimetidine.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Cimetidine.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Cimetidine.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Cimetidine.
IdelalisibThe serum concentration of Cimetidine can be increased when it is combined with Idelalisib.
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Cimetidine.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Cimetidine.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Cimetidine.
ImatinibThe serum concentration of Cimetidine can be increased when it is combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Cimetidine.
ImipramineThe serum concentration of Cimetidine can be increased when it is combined with Imipramine.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Cimetidine.
IndalpineThe metabolism of Indalpine can be decreased when combined with Cimetidine.
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Cimetidine.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Cimetidine.
IndomethacinThe serum concentration of Cimetidine can be increased when it is combined with Indomethacin.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Cimetidine.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Cimetidine.
IsavuconazoniumThe serum concentration of Cimetidine can be increased when it is combined with Isavuconazonium.
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Cimetidine.
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Cimetidine.
ItraconazoleThe serum concentration of Cimetidine can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Cimetidine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Cimetidine.
IvermectinThe serum concentration of Cimetidine can be increased when it is combined with Ivermectin.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Cimetidine.
KetamineThe serum concentration of Cimetidine can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Cimetidine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Cimetidine.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Cimetidine.
KetoconazoleThe serum concentration of Cimetidine can be increased when it is combined with Ketoconazole.
LabetalolThe metabolism of Labetalol can be decreased when combined with Cimetidine.
LacidipineThe serum concentration of Lacidipine can be increased when it is combined with Cimetidine.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Cimetidine.
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Cimetidine.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Cimetidine.
LansoprazoleThe serum concentration of Cimetidine can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Cimetidine can be increased when it is combined with Lapatinib.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Cimetidine.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Cimetidine.
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Cimetidine.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Cimetidine.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Cimetidine.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Cimetidine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Cimetidine.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Cimetidine.
LevofloxacinThe serum concentration of Cimetidine can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Cimetidine.
LevothyroxineThe serum concentration of Cimetidine can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Cimetidine can be increased when it is combined with Lidocaine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Cimetidine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Cimetidine.
LiothyronineThe serum concentration of Cimetidine can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Cimetidine can be decreased when it is combined with Liotrix.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Cimetidine.
LisinoprilThe serum concentration of Cimetidine can be increased when it is combined with Lisinopril.
LisurideThe metabolism of Lisuride can be decreased when combined with Cimetidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Cimetidine.
LomustineThe metabolism of Lomustine can be decreased when combined with Cimetidine.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Cimetidine.
LoperamideThe serum concentration of Cimetidine can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Cimetidine can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Cimetidine can be increased when it is combined with Loratadine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Cimetidine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Cimetidine.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Cimetidine.
LosartanThe serum concentration of Cimetidine can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Cimetidine can be increased when it is combined with Lovastatin.
Lu AA21004The metabolism of Lu AA21004 can be decreased when combined with Cimetidine.
LumacaftorThe serum concentration of Cimetidine can be decreased when it is combined with Lumacaftor.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Cimetidine.
MacitentanThe metabolism of Macitentan can be decreased when combined with Cimetidine.
Magnesium SulfateThe serum concentration of Magnesium Sulfate can be increased when it is combined with Cimetidine.
ManidipineThe serum concentration of Manidipine can be increased when it is combined with Cimetidine.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Cimetidine.
MaprotilineThe serum concentration of Cimetidine can be increased when it is combined with Maprotiline.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Cimetidine.
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Cimetidine.
MefloquineThe serum concentration of Cimetidine can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Cimetidine can be increased when it is combined with Megestrol acetate.
MelatoninThe metabolism of Melatonin can be decreased when combined with Cimetidine.
MephentermineMephentermine may decrease the sedative activities of Cimetidine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Cimetidine.
MeprobamateThe serum concentration of Cimetidine can be increased when it is combined with Meprobamate.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Cimetidine.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Cimetidine.
MesalazineThe therapeutic efficacy of Mesalazine can be decreased when used in combination with Cimetidine.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Cimetidine.
MetforminThe serum concentration of Metformin can be increased when it is combined with Cimetidine.
MethadoneThe serum concentration of Cimetidine can be increased when it is combined with Methadone.
MethadoneThe metabolism of Methadone can be decreased when combined with Cimetidine.
MethamphetamineMethamphetamine may decrease the sedative activities of Cimetidine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Cimetidine.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Cimetidine.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Cimetidine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Cimetidine.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Cimetidine.
MethylphenidateCimetidine can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Cimetidine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Cimetidine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Cimetidine.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Cimetidine.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Cimetidine.
MetoprololThe serum concentration of Cimetidine can be increased when it is combined with Metoprolol.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Cimetidine.
MianserinThe metabolism of Mianserin can be decreased when combined with Cimetidine.
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Cimetidine.
MiconazoleThe serum concentration of Cimetidine can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Cimetidine.
MifepristoneThe serum concentration of Cimetidine can be decreased when it is combined with Mifepristone.
MilnacipranThe metabolism of Milnacipran can be decreased when combined with Cimetidine.
MinaprineThe metabolism of Minaprine can be decreased when combined with Cimetidine.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Cimetidine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Cimetidine.
MitomycinThe serum concentration of Cimetidine can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Cimetidine.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Cimetidine.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Cimetidine.
MorphineThe serum concentration of Cimetidine can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Cimetidine.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Cimetidine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Cimetidine.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Cimetidine.
NaltrexoneThe serum concentration of Cimetidine can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Cimetidine can be increased when it is combined with Naringenin.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Cimetidine.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Cimetidine.
NefazodoneThe serum concentration of Cimetidine can be decreased when it is combined with Nefazodone.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Cimetidine.
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Cimetidine.
NeostigmineThe serum concentration of Cimetidine can be increased when it is combined with Neostigmine.
NetupitantThe metabolism of Netupitant can be decreased when combined with Cimetidine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Cimetidine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Cimetidine.
NicardipineThe serum concentration of Cimetidine can be increased when it is combined with Nicardipine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Cimetidine.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Cimetidine.
NifedipineThe serum concentration of Cimetidine can be decreased when it is combined with Nifedipine.
NiguldipineThe serum concentration of Niguldipine can be increased when it is combined with Cimetidine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Cimetidine.
NilotinibThe serum concentration of Cimetidine can be increased when it is combined with Nilotinib.
NiludipineThe serum concentration of Niludipine can be increased when it is combined with Cimetidine.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Cimetidine.
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Cimetidine.
NimesulideThe serum concentration of Nimesulide can be increased when it is combined with Cimetidine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Cimetidine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Cimetidine.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Cimetidine.
NitrazepamThe serum concentration of Cimetidine can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Cimetidine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Cimetidine.
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Cimetidine.
NorethisteroneThe serum concentration of Cimetidine can be decreased when it is combined with Norethisterone.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Cimetidine.
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Cimetidine.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Cimetidine.
OmeprazoleThe serum concentration of Cimetidine can be increased when it is combined with Omeprazole.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Cimetidine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Cimetidine.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Cimetidine.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Cimetidine.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Cimetidine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Cimetidine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Cimetidine.
P-NitrophenolThe serum concentration of Cimetidine can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Cimetidine.
PaclitaxelThe serum concentration of Cimetidine can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Cimetidine can be increased when it is combined with Palmitic Acid.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Cimetidine.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Cimetidine.
PantoprazoleThe serum concentration of Cimetidine can be increased when it is combined with Pantoprazole.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Cimetidine.
ParoxetineThe serum concentration of Cimetidine can be increased when it is combined with Paroxetine.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Cimetidine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Cimetidine.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Cimetidine.
PentobarbitalThe metabolism of Pentobarbital can be decreased when combined with Cimetidine.
PentoxifyllineThe serum concentration of Pentoxifylline can be increased when it is combined with Cimetidine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Cimetidine.
PerindoprilThe serum concentration of Cimetidine can be increased when it is combined with Perindopril.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Cimetidine.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Cimetidine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Cimetidine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Cimetidine.
PhenindioneCimetidine may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Cimetidine.
PhenprocoumonCimetidine may increase the anticoagulant activities of Phenprocoumon.
PhenterminePhentermine may decrease the sedative activities of Cimetidine.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Cimetidine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Cimetidine.
PinaveriumThe serum concentration of Pinaverium can be increased when it is combined with Cimetidine.
PindololThe metabolism of Pindolol can be decreased when combined with Cimetidine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Cimetidine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Cimetidine.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Cimetidine.
Platelet Activating FactorThe serum concentration of Cimetidine can be decreased when it is combined with Platelet Activating Factor.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Cimetidine.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Cimetidine.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Cimetidine.
PonatinibThe serum concentration of Cimetidine can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Cimetidine.
PosaconazoleThe serum concentration of Cimetidine can be increased when it is combined with Posaconazole.
PramipexoleThe serum concentration of Pramipexole can be increased when it is combined with Cimetidine.
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Cimetidine.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Cimetidine.
PravastatinThe serum concentration of Cimetidine can be increased when it is combined with Pravastatin.
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Cimetidine.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Cimetidine.
PrazosinThe serum concentration of Cimetidine can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Cimetidine.
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Cimetidine.
PrednisoneThe serum concentration of Cimetidine can be increased when it is combined with Prednisone.
PregabalinThe serum concentration of Pregabalin can be increased when it is combined with Cimetidine.
PrenylamineThe serum concentration of Prenylamine can be increased when it is combined with Cimetidine.
PrimidoneThe metabolism of Primidone can be decreased when combined with Cimetidine.
ProbenecidThe serum concentration of Cimetidine can be increased when it is combined with Probenecid.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Cimetidine.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Cimetidine.
ProgesteroneThe serum concentration of Cimetidine can be decreased when it is combined with Progesterone.
ProguanilThe metabolism of Proguanil can be decreased when combined with Cimetidine.
PromazineThe metabolism of Promazine can be decreased when combined with Cimetidine.
PromethazineThe serum concentration of Cimetidine can be increased when it is combined with Promethazine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Cimetidine.
PropafenoneThe serum concentration of Cimetidine can be increased when it is combined with Propafenone.
PropofolThe metabolism of Propofol can be decreased when combined with Cimetidine.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Cimetidine.
PropranololThe serum concentration of Cimetidine can be increased when it is combined with Propranolol.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Cimetidine.
ProtriptylineThe serum concentration of Cimetidine can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Cimetidine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Cimetidine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Cimetidine.
QuercetinThe serum concentration of Cimetidine can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Cimetidine.
QuinacrineThe serum concentration of Cimetidine can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Cimetidine.
QuinidineThe serum concentration of Cimetidine can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Cimetidine.
QuinineThe serum concentration of Cimetidine can be increased when it is combined with Quinine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Cimetidine.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Cimetidine.
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Cimetidine.
RanitidineThe serum concentration of Cimetidine can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Cimetidine.
ReboxetineThe serum concentration of Cimetidine can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Cimetidine can be increased when it is combined with Regorafenib.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Cimetidine.
repinotanThe metabolism of repinotan can be decreased when combined with Cimetidine.
ReserpineThe serum concentration of Cimetidine can be decreased when it is combined with Reserpine.
RifampicinThe serum concentration of Cimetidine can be decreased when it is combined with Rifampicin.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Cimetidine.
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Cimetidine.
RilpivirineThe serum concentration of Cimetidine can be increased when it is combined with Rilpivirine.
RisedronateThe serum concentration of Risedronate can be increased when it is combined with Cimetidine.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Cimetidine.
RitonavirThe serum concentration of Cimetidine can be decreased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Cimetidine.
RoflumilastThe serum concentration of the active metabolites of Roflumilast can be increased when Roflumilast is used in combination with Cimetidine.
RolapitantThe serum concentration of Cimetidine can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Cimetidine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Cimetidine.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Cimetidine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Cimetidine.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Cimetidine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Cimetidine.
SaquinavirThe serum concentration of Cimetidine can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Cimetidine can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Cimetidine can be increased when it is combined with Selegiline.
SelegilineThe metabolism of Selegiline can be decreased when combined with Cimetidine.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Cimetidine.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Cimetidine.
SertindoleThe metabolism of Sertindole can be decreased when combined with Cimetidine.
SertralineThe serum concentration of Cimetidine can be increased when it is combined with Sertraline.
SertralineThe metabolism of Sertraline can be decreased when combined with Cimetidine.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Cimetidine.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Cimetidine.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Cimetidine.
SimeprevirThe serum concentration of Cimetidine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Cimetidine can be increased when it is combined with Simvastatin.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Cimetidine.
SirolimusThe serum concentration of Cimetidine can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Cimetidine.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Cimetidine.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Cimetidine.
SorafenibThe serum concentration of Cimetidine can be increased when it is combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Cimetidine.
SparteineThe metabolism of Sparteine can be decreased when combined with Cimetidine.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Cimetidine.
SpironolactoneThe serum concentration of Cimetidine can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Cimetidine can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Cimetidine can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Cimetidine can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Cimetidine can be increased when it is combined with Sulfinpyrazone.
SumatriptanThe serum concentration of Cimetidine can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Cimetidine can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Cimetidine can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Cimetidine.
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Cimetidine.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Cimetidine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Cimetidine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Cimetidine.
Taurocholic AcidThe serum concentration of Cimetidine can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Cimetidine.
TegafurThe serum concentration of the active metabolites of Tegafur can be increased when Tegafur is used in combination with Cimetidine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Cimetidine.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Cimetidine.
TelmisartanThe serum concentration of Cimetidine can be increased when it is combined with Telmisartan.
TemazepamThe metabolism of Temazepam can be decreased when combined with Cimetidine.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Cimetidine.
TemsirolimusThe serum concentration of Cimetidine can be increased when it is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Cimetidine.
TerazosinThe serum concentration of Cimetidine can be increased when it is combined with Terazosin.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Cimetidine.
TerfenadineThe serum concentration of Cimetidine can be increased when it is combined with Terfenadine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Cimetidine.
TeriflunomideThe serum concentration of Cimetidine can be increased when it is combined with Teriflunomide.
TesmilifeneThe serum concentration of Cimetidine can be decreased when it is combined with Tesmilifene.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Cimetidine.
TestosteroneThe serum concentration of Cimetidine can be increased when it is combined with Testosterone.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Cimetidine.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Cimetidine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Cimetidine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Cimetidine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Cimetidine.
TianeptineThe metabolism of Tianeptine can be decreased when combined with Cimetidine.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Cimetidine.
TicagrelorThe serum concentration of Cimetidine can be increased when it is combined with Ticagrelor.
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Cimetidine.
TimololThe serum concentration of Timolol can be decreased when it is combined with Cimetidine.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Cimetidine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Cimetidine.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Cimetidine.
TolazamideThe serum concentration of Tolazamide can be increased when it is combined with Cimetidine.
TolbutamideThe serum concentration of Tolbutamide can be increased when it is combined with Cimetidine.
Tolfenamic AcidThe serum concentration of Tolfenamic Acid can be increased when it is combined with Cimetidine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Cimetidine.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Cimetidine.
TolvaptanThe serum concentration of Cimetidine can be increased when it is combined with Tolvaptan.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Cimetidine.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Cimetidine.
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Cimetidine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Cimetidine.
TranilastThe serum concentration of Tranilast can be increased when it is combined with Cimetidine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Cimetidine.
TrazodoneThe serum concentration of Cimetidine can be decreased when it is combined with Trazodone.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Cimetidine.
TrifluoperazineThe serum concentration of Cimetidine can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Cimetidine can be increased when it is combined with Triflupromazine.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Cimetidine.
TrimethoprimThe serum concentration of Cimetidine can be decreased when it is combined with Trimethoprim.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Cimetidine.
TrimipramineThe serum concentration of Cimetidine can be increased when it is combined with Trimipramine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Cimetidine.
TroleandomycinThe serum concentration of Cimetidine can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Cimetidine.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Cimetidine.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Cimetidine.
VareniclineThe serum concentration of Varenicline can be increased when it is combined with Cimetidine.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Cimetidine.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Cimetidine.
VenlafaxineThe serum concentration of Cimetidine can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Cimetidine can be decreased when it is combined with Verapamil.
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Cimetidine.
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Cimetidine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Cimetidine.
VincristineThe serum concentration of Cimetidine can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Cimetidine can be increased when it is combined with Vinorelbine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Cimetidine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Cimetidine.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Cimetidine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Cimetidine.
WarfarinThe metabolism of Warfarin can be decreased when combined with Cimetidine.
XylometazolineThe serum concentration of Xylometazoline can be increased when it is combined with Cimetidine.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Cimetidine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Cimetidine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Cimetidine.
ZiconotideThe serum concentration of Ziconotide can be increased when it is combined with Cimetidine.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Cimetidine.
ZimelidineThe metabolism of Zimelidine can be decreased when combined with Cimetidine.
ZimelidineThe serum concentration of Cimetidine can be increased when it is combined with Zimelidine.
ZolmitriptanThe serum concentration of Zolmitriptan can be increased when it is combined with Cimetidine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Cimetidine.
ZuclopenthixolThe metabolism of Zuclopenthixol can be decreased when combined with Cimetidine.
Food Interactions
  • Avoid alcohol.
  • Best effect when taken with food.
  • Limit caffeine intake.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) si...
Gene Name:
HRH2
Uniprot ID:
P25021
Molecular Weight:
40097.65 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Hernandez-Munoz R, Montiel-Ruiz C, Vazquez-Martinez O: Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab Invest. 2000 Aug;80(8):1161-9. [PubMed:10950107 ]
  3. Kuint J, Linder N, Reichman B: Hypoxemia associated with cimetidine therapy in a newborn infant. Am J Perinatol. 1996 Jul;13(5):301-3. [PubMed:8863950 ]
  4. Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. [PubMed:16723495 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. [PubMed:10385678 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y: Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther. 2002 Aug;302(2):510-5. [PubMed:12130709 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Trimethylamine monooxygenase activity
Specific Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).
Gene Name:
FMO3
Uniprot ID:
P31513
Molecular Weight:
60032.975 Da
References
  1. Cashman JR: Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000 Sep;1(2):181-91. [PubMed:11465082 ]
  2. Cashman JR, Park SB, Berkman CE, Cashman LE: Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chem Biol Interact. 1995 Apr 28;96(1):33-46. [PubMed:7720103 ]
  3. Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. doi: 10.1002/elps.200800604. [PubMed:19283698 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Nadp binding
Specific Function:
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
Gene Name:
FMO1
Uniprot ID:
Q01740
Molecular Weight:
60310.285 Da
References
  1. Hai X, Adams E, Hoogmartens J, Van Schepdael A: Enantioselective in-line and off-line CE methods for the kinetic study on cimetidine and its chiral metabolites with reference to flavin-containing monooxygenase genetic isoforms. Electrophoresis. 2009 Apr;30(7):1248-57. doi: 10.1002/elps.200800604. [PubMed:19283698 ]
  2. Cashman JR: Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000 Sep;1(2):181-91. [PubMed:11465082 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. [PubMed:12387747 ]
  2. Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. [PubMed:11303953 ]
  3. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  4. van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000 Sep;11(3):207-14. [PubMed:11042226 ]
  5. Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. [PubMed:9262363 ]
  6. Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. [PubMed:11785684 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]
  3. Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. [PubMed:12176030 ]
  4. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
  5. Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. [PubMed:10082798 ]
  6. Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA: A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb;47(2):181-6. [PubMed:10220855 ]
  7. Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. [PubMed:10960071 ]
  8. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  9. Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. [PubMed:10385678 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. [PubMed:9187257 ]
  2. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. [PubMed:9655880 ]
  3. Kakehi M, Koyabu N, Nakamura T, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Biochem Biophys Res Commun. 2002 Aug 23;296(3):644-50. [PubMed:12176030 ]
  4. Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM: Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 1997 Jun 27;272(26):16548-54. [PubMed:9195965 ]
  5. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
  6. Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. [PubMed:10082798 ]
  7. Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, Schinkel AH: Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol. 2001 Aug;21(16):5471-7. [PubMed:11463829 ]
  8. Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. [PubMed:10385678 ]
  9. Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y: Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther. 2002 Aug;302(2):510-5. [PubMed:12130709 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Toxin transporter activity
Specific Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular Weight:
61279.485 Da
References
  1. Grundemann D, Schechinger B, Rappold GA, Schomig E: Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci. 1998 Sep;1(5):349-51. [PubMed:10196521 ]
  2. Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. [PubMed:10966924 ]
  3. Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. [PubMed:9632645 ]
  4. Grundemann D, Liebich G, Kiefer N, Koster S, Schomig E: Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999 Jul;56(1):1-10. [PubMed:10385678 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. [PubMed:9618255 ]
  2. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. [PubMed:10525100 ]
  3. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. [PubMed:11669456 ]
  2. Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. [PubMed:14978359 ]
  3. Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. [PubMed:11961115 ]
  4. Burckhardt BC, Brai S, Wallis S, Krick W, Wolff NA, Burckhardt G: Transport of cimetidine by flounder and human renal organic anion transporter 1. Am J Physiol Renal Physiol. 2003 Mar;284(3):F503-9. Epub 2002 Nov 12. [PubMed:12429554 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. [PubMed:11669456 ]
  2. Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. [PubMed:14978359 ]
  3. Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]
  4. Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. [PubMed:14762099 ]
  5. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
  6. Nagata Y, Kusuhara H, Endou H, Sugiyama Y: Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol. 2002 May;61(5):982-8. [PubMed:11961115 ]
  7. Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T: Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003 Apr;23(4):432-40. [PubMed:12679720 ]
  8. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [PubMed:11306713 ]
  9. Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem. 2003;13(5):249-56. [PubMed:14586168 ]
  10. Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. [PubMed:16291876 ]
  11. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. [PubMed:10224140 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Monovalent cation:proton antiporter activity
Specific Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport...
Gene Name:
SLC47A1
Uniprot ID:
Q96FL8
Molecular Weight:
61921.585 Da
References
  1. Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC: Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. doi: 10.1124/jpet.110.170753. Epub 2010 Jun 2. [PubMed:20519552 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Molecular Weight:
62154.48 Da
References
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
  2. Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. [PubMed:10825452 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Molecular Weight:
59970.945 Da
References
  1. Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Endou H: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci. 2004 Feb;94(2):197-202. [PubMed:14978359 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
Gene Name:
SLC22A7
Uniprot ID:
Q9Y694
Molecular Weight:
60025.025 Da
References
  1. Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. [PubMed:12065749 ]
  2. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. [PubMed:10224140 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23