Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

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Link RE, Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D, Barsh GS, Kobilka BK

Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

Science. 1996 Aug 9;273(5276):803-5. doi: 10.1126/science.273.5276.803.

PubMed ID
8670422 [ View in PubMed
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Abstract

alpha2-Adrenergic receptors (alpha2ARs) are essential components of the neural circuitry regulating cardiovascular function. The role of specific alpha2AR subtypes (alpha2a, alpha2b, and alpha2c) was characterized with hemodynamic measurements obtained from strains of genetically engineered mice deficient in either alpha2b or alpha2c receptors. Stimulation of alpha2b receptors in vascular smooth muscle produced hypertension and counteracted the clinically beneficial hypotensive effect of stimulating alpha2a receptors in the central nervous system. There were no hemodynamic effects produced by disruption of the alpha2c subtype. These results provide evidence for the clinical efficacy of more subtype-selective alpha2AR drugs.

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