Travoprost.

Article Details

Citation
Copy to clipboard

Waugh J, Jarvis B

Travoprost.

Drugs Aging. 2002;19(6):465-71; discussion 472-3. doi: 10.2165/00002512-200219060-00005.

PubMed ID
12149052 [ View in PubMed
]
Abstract

Travoprost is a synthetic ester prodrug of a prostaglandin F(2alpha) analogue used in the treatment of open-angle glaucoma and ocular hypertension. Intraocular travoprost 0.004% once daily was significantly more effective at reducing intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension than placebo or timolol 0.5% twice daily and was at least as effective as latanoprost 0.005% once daily in randomised, double-blind studies. When used as adjunctive therapy with timolol 0.5% twice daily in patients with elevated IOP not adequately controlled by timolol alone, travoprost 0.004% showed significant additional IOP reduction in a randomised double-blind trial. Travoprost 0.004% was well tolerated in clinical trials. The majority of adverse events such as ocular hyperaemia and eyelash changes were mild and resolved without treatment.

DrugBank Data that Cites this Article

Drugs