Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.

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Zhang H, Matsuda H, Nakamura S, Yoshikawa M

Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3272-7. doi: 10.1016/j.bmcl.2008.04.052. Epub 2008 Apr 25.

PubMed ID
18477507 [ View in PubMed
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Abstract

Several amide constituents (piperlonguminine and retrofractamides A, B, and C) from the fruit of Piper chaba promoted adipogenesis of 3T3-L1 cells. Among them, retrofractamide A was the most active and significantly increased the amount of adiponectin released into the medium and the uptake of 2-deoxyglucose into the cells. Retrofractamide A also increased mRNA levels of adiponectin, peroxisome proliferator-activated receptor gamma2 (PPARgamma2), glucose transporter 4 (GLUT4), and insulin receptor substrate 1 (IRS-1), but did not act as a PPARgamma agonist different from troglitazone.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
TroglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)2600N/AN/ADetails