Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
Article Details
- CitationCopy to clipboard
Li W, Tao YM, Tang Y, Xu XJ, Chen J, Fu W, Wang XH, Chao B, Sheng W, Xie Q, Qiu ZB, Liu JG
Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):418-21. doi: 10.1016/j.bmcl.2009.07.119. Epub 2009 Jul 29.
- PubMed ID
- 19932964 [ View in PubMed]
- Abstract
Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Morphine Kappa-type opioid receptor Ki (nM) 6.9 N/A N/A Details