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Identification
NameMorphine
Accession NumberDB00295  (APRD00215)
TypeSmall Molecule
GroupsApproved, Investigational
Description

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(-)-MorphineNot AvailableNot Available
(−)-morphineNot AvailableNot Available
(5alpha,6alpha)-17-Methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diolNot AvailableNot Available
(5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diolNot AvailableNot Available
(5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diolNot AvailableNot Available
(7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diolNot AvailableNot Available
MorfinaNot AvailableNot Available
MorphiaNot AvailableNot Available
MorphinGermanNot Available
MorphineNot AvailableNot Available
MorphinumLatinNot Available
MorphiumNot AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Morphine Sulfatetablet15 mgoralRoxane Laboratories, Inc2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralRoxane Laboratories, Inc2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution10 mg/5mLoralRoxane Laboratories, Inc2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution20 mg/5mLoralRoxane Laboratories, Inc2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution100 mg/5mLoralRoxane Laboratories, Inc2011-01-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release10 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release20 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release30 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release50 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release80 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release100 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release200 mgoralActavis Elizabeth LLC2011-11-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution2 mg/mLintravenousHospira, Inc.2011-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution4 mg/mLintravenousHospira, Inc.2011-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution8 mg/mLintravenousHospira, Inc.2011-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution10 mg/mLintravenousHospira, Inc.2011-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution15 mg/mLintravenousHospira, Inc.2011-11-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution.5 mg/mLintravenousHospira, Inc.1992-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution1 mg/mLintravenousHospira, Inc.1992-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution5 mg/mLintravenousHospira, Inc.1992-10-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution, concentrate100 mg/5mLoralLannett Company, Inc.2011-06-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Duramorphinjection1 mg/mLepidural; intrathecal; intravenousWest Ward Pharmaceutical Corp.1984-09-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Duramorphinjection.5 mg/mLepidural; intrathecal; intravenousWest Ward Pharmaceutical Corp.1984-09-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection10 mg/.7mLintramuscularMeridian Medical Technologies, Inc.1990-07-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release60 mgoralSTAT Rx USA LLC2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release30 mgoralSTAT Rx USA LLC2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release90 mgoralSTAT Rx USA LLC2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release50 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release100 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release80 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release200 mgoralSTAT Rx USA LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release10 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralLake Erie Medical DBA Quality Care Products LLC2011-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralLake Erie Medical DBA Quality Care Products LLC2011-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release50 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release100 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release80 mgoralLake Erie Medical DBA Quality Care Products LLC2012-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, coated, extended release60 mgoralLake Erie Medical DBA Quality Care Products LLC2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release90 mgoralLake Erie Medical DBA Quality Care Products LLC2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release15 mgoralLake Erie Medical DBA Quality Care Products LLC2011-01-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release120 mgoralLake Erie Medical DBA Quality Care Products LLC2011-10-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet15 mgoralSTAT Rx USA LLC2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralSTAT Rx USA LLC2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release50 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release100 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release40 mgoralActavis Kadian LLC2012-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release70 mgoralActavis Kadian LLC2012-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release130 mgoralActavis Kadian LLC2012-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release150 mgoralActavis Kadian LLC2012-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release200 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release10 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release80 mgoralActavis Kadian LLC2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release20 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release30 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release50 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release80 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release100 mgoralPar Pharmaceutical Inc.2012-11-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet15 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release10 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release40 mgoralActavis Pharma, Inc.2012-05-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release50 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release100 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release200 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release80 mgoralActavis Pharma, Inc.2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet15 mgoralH.J. Harkins Company, Inc.2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralH.J. Harkins Company, Inc.2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet15 mgoralPhysicians Total Care, Inc.2008-01-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralPhysicians Total Care, Inc.2001-11-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release50 mgoralPhysicians Total Care, Inc.2001-11-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release100 mgoralPhysicians Total Care, Inc.2008-11-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralPhysicians Total Care, Inc.2009-05-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralPhysicians Total Care, Inc.2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution10 mg/5mLoralPhysicians Total Care, Inc.2005-09-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralPhysicians Total Care, Inc.2008-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release10 mgoralPhysicians Total Care, Inc.2008-11-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release30 mgoralCardinal Health1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release60 mgoralCardinal Health1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release100 mgoralCardinal Health1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release15 mgoralPurdue Pharma LP1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release30 mgoralPurdue Pharma LP1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release60 mgoralPurdue Pharma LP1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release100 mgoralPurdue Pharma LP1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Ms Contintablet, film coated, extended release200 mgoralPurdue Pharma LP1987-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release45 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release75 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release30 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release60 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release90 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release120 mgoralPfizer Laboratories Div Pfizer Inc2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Duramorphinjection, solution.5 mg/mLepidural; intrathecal; intravenousBaxter Healthcare Corporation2010-05-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Duramorphinjection, solution1 mg/mLepidural; intrathecal; intravenousBaxter Healthcare Corporation2010-05-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release60 mgoralbryant ranch prepack2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release120 mgoralbryant ranch prepack2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release30 mgoralbryant ranch prepack2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Avinzacapsule, extended release90 mgoralbryant ranch prepack2002-03-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralbryant ranch prepack2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet15 mgoralbryant ranch prepack2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release20 mgoralbryant ranch prepack2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release30 mgoralbryant ranch prepack2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kadiancapsule, extended release60 mgoralbryant ranch prepack2009-04-07Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet30 mgoralDispensing Solutions, Inc.2008-03-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution2 mg/mLintravenousBD Rx Inc.2013-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution4 mg/mLintravenousBD Rx Inc.2013-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution5 mg/mLintravenousBD Rx Inc.2013-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution8 mg/mLintravenousBD Rx Inc.2013-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution10 mg/mLintravenousBD Rx Inc.2013-02-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Morphine Sulfatecapsule, extended release30 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release90 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release120 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release45 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release75 mgoralActavis Elizabeth LLC2014-02-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralMylan Pharmaceuticals Inc.2011-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralMylan Pharmaceuticals Inc.2011-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release60 mgoralMylan Pharmaceuticals Inc.2011-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release100 mgoralMylan Pharmaceuticals Inc.2011-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release200 mgoralMylan Pharmaceuticals Inc.2011-10-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution20 mg/mLoralMallinckrodt, Inc.2011-10-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release15 mgoralMallinckrodt, Inc.2010-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release200 mgoralMallinckrodt, Inc.2010-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release30 mgoralMallinckrodt, Inc.2010-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release60 mgoralMallinckrodt, Inc.2010-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release100 mgoralMallinckrodt, Inc.2010-10-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution.5 mg/mLepidural; intrathecal; intravenousHospira, Inc.1992-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution1 mg/mLepidural; intrathecal; intravenousHospira, Inc.1992-09-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution.5 mg/mLepidural; intrathecal; intravenousHospira, Inc.1988-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfateinjection, solution1 mg/mLepidural; intrathecal; intravenousHospira, Inc.1988-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution100 mg/5mLoralPaddock Laboratories, LLC2012-08-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release20 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release30 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release50 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release100 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release80 mgoralWatson Laboratories, Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralWatson Laboratories, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralWatson Laboratories, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release60 mgoralWatson Laboratories, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release100 mgoralWatson Laboratories, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release200 mgoralWatson Laboratories, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release10 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release20 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release30 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release50 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release80 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release100 mgoralUpsher Smith Laboratories, Inc.2013-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralSTAT Rx USA LLC2011-01-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralPd Rx Pharmaceuticals, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralPd Rx Pharmaceuticals, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release60 mgoralPd Rx Pharmaceuticals, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release100 mgoralPd Rx Pharmaceuticals, Inc.1987-05-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution20 mg/mLoralSafecor Health, LLC2013-01-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release20 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release30 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release50 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release60 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release80 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatecapsule, extended release100 mgoralPar Pharmaceutical Inc.2011-11-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralH.J. Harkins Company, Inc.2011-01-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralH.J. Harkins Company, Inc.2011-01-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release30 mgoralPhysicians Total Care, Inc.2005-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release60 mgoralPhysicians Total Care, Inc.2004-04-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release15 mgoralPhysicians Total Care, Inc.2004-08-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release100 mgoralPhysicians Total Care, Inc.2006-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution20 mg/5mLoralCaraco Pharmaceutical Laboratories, Ltd.2012-01-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralEthex Corporation2009-12-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralEthex Corporation2010-04-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release60 mgoralEthex Corporation2010-04-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release100 mgoralEthex Corporation2009-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release200 mgoralEthex Corporation2009-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release15 mgoralQualitest Pharmaceuticals1998-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release30 mgoralQualitest Pharmaceuticals1998-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release60 mgoralQualitest Pharmaceuticals1998-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release100 mgoralQualitest Pharmaceuticals1998-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, extended release200 mgoralQualitest Pharmaceuticals1998-10-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralRanbaxy Pharmaceuticals Inc.2012-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralRanbaxy Pharmaceuticals Inc.2012-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release100 mgoralRanbaxy Pharmaceuticals Inc.2012-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release200 mgoralRanbaxy Pharmaceuticals Inc.2012-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release60 mgoralRanbaxy Pharmaceuticals Inc.2012-05-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralbryant ranch prepack2010-03-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release15 mgoralbryant ranch prepack2011-01-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatetablet, film coated, extended release30 mgoralbryant ranch prepack2011-01-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution10 mg/5mLoralVista Pharm Inc.2012-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Morphine Sulfatesolution20 mg/5mLoralVista Pharm Inc.2012-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
KapanolNot Available
MSIRNot Available
OramorphNot Available
RoxanolNot Available
Brand mixtures
Brand NameIngredients
Camphorated Opium TinctureBenzoic Acid + Camphor + Morphine
ParegoriqueCamphor + Morphine
Salts
Name/CASStructureProperties
Morphine Sulfate
Thumb
  • InChI Key: USAHOPJHPJHUNS-IFCNUISUSA-N
  • Monoisotopic Mass: 668.2403662
  • Average Mass: 668.754
DBSALT000122
Categories
CAS number57-27-2
WeightAverage: 285.3377
Monoisotopic: 285.136493479
Chemical FormulaC17H19NO3
InChI KeyBQJCRHHNABKAKU-KBQPJGBKSA-N
InChI
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
IUPAC Name
(1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraene-10,14-diol
SMILES
[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Benzylisoquinoline
  • Phenanthrene
  • Tetralin
  • Benzofuran
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the relief and treatment of severe pain.
PharmacodynamicsMorphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Mechanism of actionThe precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. Morphine first acts on the mu-opioid receptors. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. It has been shown that morphine binds to and inhibits GABA inhibitory interneurons. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
AbsorptionBioavailability is approximately 30%.
Volume of distribution
  • 1 to 6 L/kg
Protein binding30-40%
Metabolism

Primarily hepatic (90%), converted to dihydromorphinone and normorphine. Also converted to morphine-3-glucuronide (M3G) and morphine-6-glucuronide. Virtually all morphine is converted to glucuronide metabolites; only a small fraction (less than 5%) of absorbed morphine is demethylated.

SubstrateEnzymesProduct
Morphine
morphine-6-glucuronideDetails
Morphine
morphine-3-glucuronideDetails
Morphine
Not Available
NormorphineDetails
Route of eliminationA small amount of glucuronide conjugates are excreted in bile, with minor enterohepatic recycling. Seven to 10% of administered morphine sulfate is excreted in the feces.
Half life2-4 hours
Clearance
  • 20 – 30 mL/min/kg [Adult]
  • 1852 +/- 116 mL/min [Chinese]
  • 1495 +/- 80 mL/min [Caucasian]
ToxicityLD50 = 461 mg/kg (rat, oral), 600 mg/kg (mouse, oral). Human lethal dose by ingestion is 120-250 mg of morphine sulfate. Symptoms of overdose include cold, clammy skin, flaccid muscles, fluid in the lungs, lowered blood pressure, "pinpoint" or dilated pupils, sleepiness leading to stupor and coma, slowed breathing, and slow pulse rate.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Morphine Metabolism PathwayDrug metabolismSMP00622
Heroin Metabolism PathwayDrug metabolismSMP00623
Codeine Metabolism PathwayDrug metabolismSMP00621
Morphine Action PathwayDrug actionSMP00406
Heroin Action PathwayDrug actionSMP00407
Codeine Action PathwayDrug actionSMP00405
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Multidrug resistance protein 1
Gene symbol: ABCB1
UniProt: P08183
rs1045642 Not AvailableT AlleleBetter response to pain relief drugs17898703
Mu-type opioid receptor
Gene symbol: OPRM1
UniProt: P35372
rs1799971 Not AvailableA AlleleBetter response to pain relief drugs17898703
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9971
Blood Brain Barrier+0.9882
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8787
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.956
Renal organic cation transporterInhibitor0.6221
CYP450 2C9 substrateNon-substrate0.7451
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateSubstrate0.7375
CYP450 1A2 substrateNon-inhibitor0.5191
CYP450 2C9 substrateNon-inhibitor0.9046
CYP450 2D6 substrateNon-inhibitor0.647
CYP450 2C19 substrateNon-inhibitor0.8155
CYP450 3A4 substrateNon-inhibitor0.9176
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7503
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9634
BiodegradationNot ready biodegradable0.9944
Rat acute toxicity2.8989 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8367
hERG inhibition (predictor II)Non-inhibitor0.874
Pharmacoeconomics
Manufacturers
  • King pharmaceuticals inc
  • Actavis elizabeth llc
  • Ekr therapeutics inc
  • App pharmaceuticals llc
  • Baxter healthcare corp anesthesia and critical care
  • Hospira inc
  • Mallinckrodt chemical inc
  • Meridian medical technologies inc
  • Watson laboratories inc
  • Roxane laboratories inc
  • Clonmel healthcare ltd
  • Endo pharmaceuticals inc
  • Kv pharmaceutical co
  • Mallinckrodt inc
  • Purdue pharma lp
  • Xanodyne pharmaceutics inc
  • Actavis
Packagers
Dosage forms
FormRouteStrength
Capsule, coated, extended releaseoral60 mg
Capsule, extended releaseoral10 mg
Capsule, extended releaseoral100 mg
Capsule, extended releaseoral120 mg
Capsule, extended releaseoral130 mg
Capsule, extended releaseoral150 mg
Capsule, extended releaseoral20 mg
Capsule, extended releaseoral200 mg
Capsule, extended releaseoral30 mg
Capsule, extended releaseoral40 mg
Capsule, extended releaseoral45 mg
Capsule, extended releaseoral50 mg
Capsule, extended releaseoral60 mg
Capsule, extended releaseoral70 mg
Capsule, extended releaseoral75 mg
Capsule, extended releaseoral80 mg
Capsule, extended releaseoral90 mg
Injectionepidural; intrathecal; intravenous.5 mg/mL
Injectionepidural; intrathecal; intravenous1 mg/mL
Injectionintramuscular10 mg/.7mL
Injection, solutionepidural; intrathecal; intravenous.5 mg/mL
Injection, solutionepidural; intrathecal; intravenous1 mg/mL
Injection, solutionintravenous.5 mg/mL
Injection, solutionintravenous1 mg/mL
Injection, solutionintravenous10 mg/mL
Injection, solutionintravenous15 mg/mL
Injection, solutionintravenous2 mg/mL
Injection, solutionintravenous4 mg/mL
Injection, solutionintravenous5 mg/mL
Injection, solutionintravenous8 mg/mL
Solutionoral10 mg/5mL
Solutionoral100 mg/5mL
Solutionoral20 mg/5mL
Solutionoral20 mg/mL
Solution, concentrateoral100 mg/5mL
Tabletoral15 mg
Tabletoral30 mg
Tablet, extended releaseoral100 mg
Tablet, extended releaseoral15 mg
Tablet, extended releaseoral200 mg
Tablet, extended releaseoral30 mg
Tablet, extended releaseoral60 mg
Tablet, film coated, extended releaseoral100 mg
Tablet, film coated, extended releaseoral15 mg
Tablet, film coated, extended releaseoral200 mg
Tablet, film coated, extended releaseoral30 mg
Tablet, film coated, extended releaseoral60 mg
Prices
Unit descriptionCostUnit
Depodur 15 mg/1.5 ml vial618.18USD ml
Roxanol 20 mg/ml Solution 120ml Bottle95.98USD bottle
Morphine Sulfate 20 mg/5ml Solution 500ml Bottle65.05USD bottle
Apokyn 30 mg/3 ml cartridge52.48USD ml
Morphine Sulfate 10 mg/5ml Solution 500ml Bottle38.55USD bottle
Kadian er 200 mg capsule35.43USD capsule
Kadian er 100 mg capsule23.01USD capsule
Roxanol 20 mg/ml Solution 30ml Bottle22.99USD bottle
Morphine Sulfate 10 mg/5ml Solution 100ml Bottle21.99USD bottle
Oramorph sr 60 mg tablet21.76USD tablet
Ms contin 200 mg tablet21.5USD tablet
Kadian er 80 mg capsule18.66USD capsule
Roxanol 20 mg/ml Solution 240ml Bottle17.99USD bottle
Avinza 90 mg capsule17.56USD capsule
Oramorph sr 100 mg tablet17.16USD tablet
Kadian 100 mg 24 Hour Capsule16.93USD capsule
MS Contin 200 mg 12 Hour tablet16.32USD tablet
Kadian 100 mg capsule sr16.25USD capsule
Kadian er 60 mg capsule14.31USD capsule
AVINza 90 mg 24 Hour Capsule13.21USD capsule
Kadian 80 mg capsule sr12.96USD capsule
Avinza 120 mg capsule12.07USD capsule
Kadian er 50 mg capsule11.76USD capsule
Ms contin 100 mg tablet11.75USD tablet
Avinza 60 mg capsule11.58USD capsule
AVINza 120 mg 24 Hour Capsule11.33USD capsule
Avinza 75 mg capsule10.79USD capsule
Morphine sulfate powder10.61USD g
Avinza 45 mg capsule10.22USD capsule
Kadian 60 mg 24 Hour Capsule9.06USD capsule
Morphine Sulfate CR 200 mg 12 Hour tablet8.97USD tablet
MS Contin 100 mg 12 Hour tablet8.89USD tablet
Morphine sulf 30 mg suppository8.44USD suppository
AVINza 60 mg 24 Hour Capsule8.36USD capsule
Ms contin 60 mg tablet7.95USD tablet
Infumorph 10 mg/ml ampul p-f7.8USD ml
Kadian 50 mg 24 Hour Capsule7.71USD capsule
Kadian er 30 mg capsule7.13USD capsule
Oramorph sr 30 mg tablet6.83USD tablet
Morphine sulf 20 mg suppository6.71USD suppository
Kadian er 10 mg capsule6.35USD capsule
Morphine sulf 10 mg suppository6.25USD suppository
Avinza 30 mg capsule6.0USD capsule
MS Contin 60 mg 12 Hour tablet5.71USD tablet
Kadian er 20 mg capsule5.69USD capsule
Ms Contin 200 mg Sustained-Release Tablet5.62USD tablet
Kadian 30 mg 24 Hour Capsule4.8USD capsule
Kadian 20 mg 24 Hour Capsule4.76USD capsule
AVINza 30 mg 24 Hour Capsule4.47USD capsule
Morphine sulf 5 mg suppository4.45USD suppository
Morphine Sulfate CR 100 mg 12 Hour tablet4.33USD tablet
M-Eslon 200 mg Extended-Release Capsule4.3USD capsule
Oramorph sr 15 mg tablet4.12USD tablet
Ms contin cr 30 mg tablet4.09USD tablet
Kadian 10 mg capsule sr4.05USD capsule
Morphine Hp 50 50 mg/ml4.01USD ml
Kadian 10 mg 24 Hour Capsule4.0USD capsule
Ms contin 15 mg tablet3.58USD tablet
MS Contin 30 mg 12 Hour tablet3.26USD tablet
Novo-Morphine Sr 200 mg Sustained-Release Tablet3.09USD tablet
Pms-Morphine Sulfate Sr 200 mg Sustained-Release Tablet3.09USD tablet
Ms Contin 100 mg Sustained-Release Tablet3.02USD tablet
Morphine Sulfate CR 60 mg 12 Hour tablet3.0USD tablet
Morphine Hp 25 25 mg/ml2.9USD ml
Statex 30 mg Suppository2.55USD suppository
Kadian 100 mg Sustained-Release Capsule2.35USD capsule
Statex 20 mg Suppository2.32USD suppository
Morphine Lp Epidural 1 mg/ml2.24USD ml
M-Eslon 100 mg Extended-Release Capsule2.15USD capsule
MS Contin 15 mg 12 Hour tablet2.13USD tablet
Ms Contin 60 mg Sustained-Release Tablet1.98USD tablet
Statex 10 mg Suppository1.95USD suppository
Morph sulf 5 mg/0.25 ml vial1.83USD vial
Statex 5 mg Suppository1.75USD suppository
Novo-Morphine Sr 100 mg Sustained-Release Tablet1.66USD tablet
Pms-Morphine Sulfate Sr 100 mg Sustained-Release Tablet1.66USD tablet
Morphine Sulfate CR 30 mg 12 Hour tablet1.63USD tablet
Morphine 8 mg/ml ampule1.56USD ml
Kadian 50 mg Sustained-Release Capsule1.35USD capsule
Duramorph 0.5 mg/ml ampul1.31USD ml
Astramorph-pf 1 mg/ml ampul1.15USD ml
Ms Contin 30 mg Sustained-Release Tablet1.13USD tablet
Morphine Lp Epidural 0.5 mg/ml1.12USD ml
Morphine Sulfate 15 mg/ml1.03USD ml
Morphine Sulfate 10 mg/ml1.02USD ml
Novo-Morphine Sr 60 mg Sustained-Release Tablet1.01USD tablet
Pms-Morphine Sulfate Sr 60 mg Sustained-Release Tablet1.01USD tablet
Ratio-Morphine Sulfate Sr 60 mg Sustained-Release Tablet1.01USD tablet
M-Eslon 60 mg Extended-Release Capsule1.0USD capsule
Statex 50 mg/ml Drops0.99USD ml
Morphine Sulfate CR 15 mg 12 Hour tablet0.93USD tablet
Duramorph 1 mg/ml ampul0.91USD ml
M.O.S.-Sr 60 mg Sustained-Release Tablet0.89USD tablet
Morphine 50 mg/25 ml-d5w syr0.86USD ml
Morphine-ns 10 mg/ml syringe0.86USD ml
Morphine-ns 5 mg/ml syringe0.8USD ml
Ms Contin 15 mg Sustained-Release Tablet0.75USD tablet
Morphine 5 mg/ml vial0.74USD ml
Kadian 20 mg Sustained-Release Capsule0.73USD capsule
Astramorph-pf 0.5 mg/ml amp0.72USD ml
Morphine Sulfate 15 mg tablet0.65USD tablet
Morphine Sulfate 30 mg tablet0.65USD tablet
Morphine 1 mg/ml vial p-f0.6USD ml
Morphine-ns 1 mg/ml syringe0.58USD ml
Novo-Morphine Sr 30 mg Sustained-Release Tablet0.57USD tablet
Pms-Morphine Sulfate Sr 30 mg Sustained-Release Tablet0.57USD tablet
Ratio-Morphine Sulfate Sr 30 mg Sustained-Release Tablet0.57USD tablet
M-Eslon 30 mg Extended-Release Capsule0.56USD capsule
Morphine 0.5 mg/ml vial0.55USD ml
Morphine sulfate 50 mg/ml vial0.55USD ml
Morphine sulfate ir 30 mg tablet0.55USD tablet
Ratio-Morphine 20 mg/ml Syrup0.55USD syrup
Statex 20 mg/ml Drops0.52USD ml
M.O.S.-Sr 30 mg Sustained-Release Tablet0.51USD tablet
Morphine 1 mg/ml syringe0.48USD ml
Morphine 10 mg/ml vial0.48USD ml
Ms.Ir 30 mg Tablet0.48USD tablet
Morphine sulfate 25 mg/ml vial0.43USD ml
Morphine sulf 1 mg/ml vial0.4USD ml
M.O.S. Sulfate 50 mg Tablet0.39USD tablet
Statex 50 mg Tablet0.39USD tablet
Kadian 10 mg Sustained-Release Capsule0.38USD capsule
M-Eslon 15 mg Extended-Release Capsule0.38USD capsule
Ms.Ir 20 mg Tablet0.38USD tablet
Novo-Morphine Sr 15 mg Sustained-Release Tablet0.37USD tablet
Pms-Morphine Sulfate Sr 15 mg Sustained-Release Tablet0.37USD tablet
Ratio-Morphine Sulfate Sr 15 mg Sustained-Release Tablet0.37USD tablet
M-Eslon 10 mg Extended-Release Capsule0.33USD capsule
Morphine sulfate ir 15 mg tablet0.32USD tablet
Morphine 15 mg/ml vial0.3USD ml
Morphine-ns 25 mg/25 ml syr0.26USD ml
M.O.S. Sulfate 25 mg Tablet0.25USD tablet
Statex 25 mg Tablet0.25USD tablet
Ms.Ir 10 mg Tablet0.21USD tablet
Ratio-Morphine 10 mg/ml Syrup0.19USD syrup
M.O.S. Sulfate 10 mg Tablet0.19USD tablet
Statex 10 mg Tablet0.19USD tablet
Morphine-ns 5 mg/ml0.16USD ml
Morphine-ns 55 mg/55 ml syr0.14USD ml
Ms.Ir 5 mg Tablet0.14USD tablet
M.O.S. Sulfate 5 mg Tablet0.12USD tablet
Statex 5 mg Tablet0.12USD tablet
Morphine 1 mg/ml-d5w 100 ml0.1USD ml
Morphine-ns 150 mg/150 ml0.1USD ml
Statex 5 mg/ml Syrup0.08USD ml
Morphine 1 mg/ml-d5w 250 ml0.06USD ml
Ratio-Morphine 5 mg/ml Syrup0.05USD syrup
Ratio-Morphine 1 mg/ml Syrup0.02USD syrup
Statex 1 mg/ml Syrup0.02USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada20652102000-08-292012-04-06
Canada21285911999-03-232014-07-21
United States53784741993-03-232010-03-23
United States60663391997-11-252017-11-25
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255 °CPhysProp
water solubility149 mg/L (at 20 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP0.89AVDEEF,A ET AL. (1996)
logS-3.28ADME Research, USCD
pKa8.21 (at 25 °C)LIDE,DR (1995)
Predicted Properties
PropertyValueSource
Water Solubility10.2 mg/mLALOGPS
logP0.99ALOGPS
logP0.9ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)10.26ChemAxon
pKa (Strongest Basic)9.12ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area52.93 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity80.12 m3·mol-1ChemAxon
Polarizability29.95 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (9.42 KB)
SpectraNot Available
References
Synthesis Reference

Nagaraj R. Ayyangar, Anil R. Choudhary, Uttam R. Kalkote, Vasant K. Sharma, “Process for the preparation of codeine from morphine.” U.S. Patent US4764615, issued May, 1912.

US4764615
General Reference
  1. Kilpatrick GJ, Smith TW: Morphine-6-glucuronide: actions and mechanisms. Med Res Rev. 2005 Sep;25(5):521-44. Pubmed
  2. Loguinov AV, Anderson LM, Crosby GJ, Yukhananov RY: Gene expression following acute morphine administration. Physiol Genomics. 2001 Aug 28;6(3):169-81. Pubmed
External Links
ATC CodesN02AA01
AHFS Codes
  • 28:08.08
  • 84:24.12
PDB EntriesNot Available
FDA labelDownload (1.2 MB)
MSDSDownload (51.7 KB)
Interactions
Drug Interactions
Drug
AlvimopanIncreases levels by receptor binding competition. Discontinue opioid administration at least 7 days prior to administrating Alvimopan.
EltrombopagEltrombopag increases Morphine levels via decreasing metabolism. UDP-glucuronosyltransferase inhibition with unclear significance.
RifampicinRifampin decreases the effect of morphine/codeine
TriprolidineThe CNS depressants, Triprolidine and Morphine, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
TrovafloxacinMorphine may reduce serum levels of Trovafloxacin decreasing the efficacy of the antibiotic. IV doses of morphine should be administered at least 2 hours after a dose of Trovafloxacin given in a fasting state or 4 hours after if given in a fed state.
Food Interactions
  • Avoid alcohol.
  • Take with food.
  • To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).

Targets

1. Mu-type opioid receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Mu-type opioid receptor P35372 Details

References:

  1. Yamada H, Shimoyama N, Sora I, Uhl GR, Fukuda Y, Moriya H, Shimoyama M: Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors. Brain Res. 2006 Apr 14;1083(1):61-9. Epub 2006 Mar 10. Pubmed
  2. Kasai S, Han W, Ide S, Hata H, Takamatsu Y, Yamamoto H, Uhl GR, Sora I, Ikeda K: Involvement of the 3’ non-coding region of the mu opioid receptor gene in morphine-induced analgesia. Psychiatry Clin Neurosci. 2006 Apr;60 Suppl 1:S11-7. doi:10.1111/j.1440-1819.2006.01523.x-i1
  3. Choi HS, Kim CS, Hwang CK, Song KY, Wang W, Qiu Y, Law PY, Wei LN, Loh HH: The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochem Biophys Res Commun. 2006 May 19;343(4):1132-40. Epub 2006 Mar 23. Pubmed
  4. Castro RR, Cunha FQ, Silva FS Jr, Rocha FA: A quantitative approach to measure joint pain in experimental osteoarthritis—evidence of a role for nitric oxide. Osteoarthritis Cartilage. 2006 Aug;14(8):769-76. Epub 2006 Mar 31. Pubmed
  5. Johnson EA, Oldfield S, Braksator E, Gonzalez-Cuello A, Couch D, Hall KJ, Mundell SJ, Bailey CP, Kelly E, Henderson G: Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells. Mol Pharmacol. 2006 Aug;70(2):676-85. Epub 2006 May 8. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  7. Yekkirala AS, Kalyuzhny AE, Portoghese PS: Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala2-MePhe4-Glyol5] enkephalin as selective μ−δ agonists. ACS Chem. Neurosci. 2010; 1(2):146-154 doi:10.1021/cn9000236

2. Kappa-type opioid receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Kappa-type opioid receptor P41145 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Leventhal L, Silva RM, Rossi GC, Pasternak GW, Bodnar RJ: Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. J Pharmacol Exp Ther. 1998 Nov;287(2):538-44. Pubmed
  4. Kozak CA, Filie J, Adamson MC, Chen Y, Yu L: Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics. 1994 Jun;21(3):659-61. Pubmed
  5. Teodorov E, Modena CC, Sukikara MH, Felicio LF: Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Neuroscience. 2006 Sep 1;141(3):1225-31. Epub 2006 Jun 6. Pubmed
  6. Yekkirala AS, Kalyuzhny AE, Portoghese PS: Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala2-MePhe4-Glyol5] enkephalin as selective μ−δ agonists. ACS Chem. Neurosci. 2010; 1(2):146-154 doi:10.1021/cn9000236

3. Delta-type opioid receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Delta-type opioid receptor P41143 Details

References:

  1. Yamada H, Shimoyama N, Sora I, Uhl GR, Fukuda Y, Moriya H, Shimoyama M: Morphine can produce analgesia via spinal kappa opioid receptors in the absence of mu opioid receptors. Brain Res. 2006 Apr 14;1083(1):61-9. Epub 2006 Mar 10. Pubmed
  2. Dortch-Carnes J, Russell KR: Morphine-induced reduction of intraocular pressure and pupil diameter: role of nitric oxide. Pharmacology. 2006;77(1):17-24. Epub 2006 Mar 13. Pubmed
  3. Koch T, Wu DF, Yang LQ, Brandenburg LO, Hollt V: Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors. J Neurochem. 2006 Apr;97(2):365-72. Epub 2006 Mar 15. Pubmed
  4. Galeotti N, Stefano GB, Guarna M, Bianchi E, Ghelardini C: Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain. 2006 Aug;123(3):294-305. Epub 2006 May 2. Pubmed
  5. Asensio VJ, Miralles A, Garcia-Sevilla JA: Stimulation of mitogen-activated protein kinase kinases (MEK1/2) by mu-, delta- and kappa-opioid receptor agonists in the rat brain: regulation by chronic morphine and opioid withdrawal. Eur J Pharmacol. 2006 Jun 6;539(1-2):49-56. Epub 2006 Apr 6. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  7. Kieffer BL, Gaveriaux-Ruff C: Exploring the opioid system by gene knockout. Prog Neurobiol. 2002 Apr;66(5):285-306. Pubmed
  8. Yekkirala AS, Kalyuzhny AE, Portoghese PS: Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala2-MePhe4-Glyol5] enkephalin as selective μ−δ agonists. ACS Chem. Neurosci. 2010; 1(2):146-154 doi:10.1021/cn9000236

Enzymes

1. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 2C8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. UDP-glucuronosyltransferase 2B7

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B7 P16662 Details

References:

  1. Coffman BL, Rios GR, King CD, Tephly TR: Human UGT2B7 catalyzes morphine glucuronidation. Drug Metab Dispos. 1997 Jan;25(1):1-4. Pubmed
  2. Takeda S, Ishii Y, Iwanaga M, Mackenzie PI, Nagata K, Yamazoe Y, Oguri K, Yamada H: Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4. Mol Pharmacol. 2005 Mar;67(3):665-72. Epub 2004 Dec 20. Pubmed
  3. Yamada H, Ishii K, Ishii Y, Ieiri I, Nishio S, Morioka T, Oguri K: Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain. J Toxicol Sci. 2003 Dec;28(5):395-401. Pubmed
  4. Abildskov K, Weldy P, Garland M: Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. Drug Metab Dispos. 2010 Apr;38(4):545-53. Epub 2010 Jan 13. Pubmed

5. UDP-glucuronosyltransferase 1-1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-1 P22309 Details

References:

  1. Ohno S, Kawana K, Nakajin S: Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. Drug Metab Dispos. 2008 Apr;36(4):688-94. Epub 2008 Jan 10. Pubmed

6. UDP-glucuronosyltransferase 1-8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-8 Q9HAW9 Details

References:

  1. Ohno S, Kawana K, Nakajin S: Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. Drug Metab Dispos. 2008 Apr;36(4):688-94. Epub 2008 Jan 10. Pubmed

7. UDP-glucuronosyltransferase 2B15

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B15 P54855 Details

References:

  1. Abildskov K, Weldy P, Garland M: Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. Drug Metab Dispos. 2010 Apr;38(4):545-53. Epub 2010 Jan 13. Pubmed

8. UDP-glucuronosyltransferase 2B4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 2B4 P06133 Details

References:

  1. Abildskov K, Weldy P, Garland M: Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. Drug Metab Dispos. 2010 Apr;38(4):545-53. Epub 2010 Jan 13. Pubmed

9. UDP-glucuronosyltransferase 1-3

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
UDP-glucuronosyltransferase 1-3 P35503 Details

References:

  1. Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR: Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos. 1998 Jun;26(6):507-12. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. Pubmed
  2. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:09