Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
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Reitz DB, Li JJ, Norton MB, Reinhard EJ, Collins JT, Anderson GD, Gregory SA, Koboldt CM, Perkins WE, Seibert K, et al.
Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
J Med Chem. 1994 Nov 11;37(23):3878-81.
- PubMed ID
- 7966148 [ View in PubMed]
- Abstract
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Indomethacin Prostaglandin G/H synthase 2 IC 50 (nM) 1200 N/A N/A Details