Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.

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Woods KW, McCroskey RW, Michaelides MR, Wada CK, Hulkower KI, Bell RL

Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.

Bioorg Med Chem Lett. 2001 May 21;11(10):1325-8.

PubMed ID

11392547 [ View in PubMed

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Abstract

The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Indomethacin	Prostaglandin G/H synthase 2	IC 50 (nM)	30	N/A	N/A	Details