Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.

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Hosek J, Bartos M, Chudik S, Dall'Acqua S, Innocenti G, Kartal M, Kokoska L, Kollar P, Kutil Z, Landa P, Marek R, Zavalova V, Zemlicka M, Smejkal K

Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.

J Nat Prod. 2011 Apr 25;74(4):614-9. doi: 10.1021/np100638h. Epub 2011 Feb 14.

PubMed ID

21319773 [ View in PubMed

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Abstract

Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor alpha (TNFalpha) gene expression and secretion by blocking the translocation of nuclear factor kappaB (NF-kappaB) from the cytoplasm to the nucleus in macrophages derived from a THP-1 human monocyte cell line. The NF-kappaB activity reduction resulted in the inhibition of cyclooxygenase 2 (COX-2) gene expression. Compound 1 acts as a COX-2 and COX-1 inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable anti-inflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Indomethacin	Prostaglandin G/H synthase 2	IC 50 (nM)	1900	N/A	N/A	Details