Conformation-specific effects of Raf kinase inhibitors.

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Wang X, Kim J

Conformation-specific effects of Raf kinase inhibitors.

J Med Chem. 2012 Sep 13;55(17):7332-41. doi: 10.1021/jm300613w. Epub 2012 Aug 3.

PubMed ID

22808911 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
PLX-4720	Serine/threonine-protein kinase B-raf	IC 50 (nM)	160	N/A	N/A	Details
PLX-4720	Serine/threonine-protein kinase B-raf	IC 50 (nM)	46	N/A	N/A	Details
PLX-4720	Serine/threonine-protein kinase B-raf	Ki (nM)	2.6	N/A	N/A	Details
Sorafenib	RAF proto-oncogene serine/threonine-protein kinase	IC 50 (nM)	6	N/A	N/A	Details
Sorafenib	Serine/threonine-protein kinase B-raf	IC 50 (nM)	22	N/A	N/A	Details
Vemurafenib	Serine/threonine-protein kinase B-raf	IC 50 (nM)	100	N/A	N/A	Details