Design and synthesis of a novel class of dual PPARgamma/delta agonists.
Article Details
- CitationCopy to clipboard
Gonzalez IC, Lamar J, Iradier F, Xu Y, Winneroski LL, York J, Yumibe N, Zink R, Montrose-Rafizadeh C, Etgen GJ, Broderick CL, Oldham BA, Mantlo N
Design and synthesis of a novel class of dual PPARgamma/delta agonists.
Bioorg Med Chem Lett. 2007 Feb 15;17(4):1052-5. Epub 2006 Nov 15.
- PubMed ID
- 17129725 [ View in PubMed]
- Abstract
The design and synthesis of dual PPAR gamma/delta agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Rosiglitazone Peroxisome proliferator-activated receptor gamma EC 50 (nM) 308 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 67 N/A N/A Details