Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.

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Ahn JH, Shin MS, Jung SH, Kim JA, Kim HM, Kim SH, Kang SK, Kim KR, Rhee SD, Park SD, Lee JM, Lee JH, Cheon HG, Kim SS

Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5239-44. Epub 2007 Jun 30.

PubMed ID
17624777 [ View in PubMed
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Abstract

A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARgamma. The best PPARgamma agonist in this series was 9h, which showed an EC(50) value of 15 nM.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
RosiglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)320N/AN/ADetails