Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.

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Zhang J, Wang J, Wu H, He Y, Zhu G, Cui X, Tang L

Design, synthesis and insulin-sensitizing activity of indomethacin and diclofenac derivatives.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3324-7. doi: 10.1016/j.bmcl.2009.04.050. Epub 2009 Apr 18.

PubMed ID

19423341 [ View in PubMed

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Abstract

A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rosiglitazone	Peroxisome proliferator-activated receptor gamma	EC 50 (nM)	10000000	N/A	N/A	Details