Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.

Article Details

Citation

Copy to clipboard

Huffman JW, Thompson AL, Wiley JL, Martin BR

Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.

Bioorg Med Chem. 2008 Jan 1;16(1):322-35. Epub 2007 Sep 22.

PubMed ID

17919913 [ View in PubMed

]

Abstract

A series of 1-deoxy analogs of CP-47,497 (8 and 13, n=0-7) and 1-deoxy analogs of CP-55,940 (9, n=0-7) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although the majority of these compounds exhibit selectivity for the CB(2) receptor, none have greater than modest affinity for either receptor. The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Dronabinol	Cannabinoid receptor 2	Ki (nM)	36	N/A	N/A	Details