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Identification
NameDronabinol
Accession NumberDB00470  (APRD00571)
TypeSmall Molecule
GroupsApproved, Illicit
DescriptionA psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem]
Structure
Thumb
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol
1-trans-delta-9-Tetrahydrocannabinol
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
delta-9-tetrahydrocannabinol
delta-9-THC
delta(1)-Tetrahydrocannabinol
delta(9)-THC
delta9-Tetrahydrocannabinol
Dronabinol
Dronabinolum
Tetrahydrocannabinol
Δ9-tetrahydrocannabinol
External Identifiers
  • Abbott 40566
  • Dea No. 7369
  • Dea No. 7370
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dronabinolcapsule5 mg/1oralActavis Pharma, Inc.2005-06-07Not applicableUs
Dronabinolcapsule10 mg/1oralActavis Pharma, Inc.1994-08-11Not applicableUs
Dronabinolcapsule2.5 mg/1oralActavis Pharma, Inc.1994-08-11Not applicableUs
Marinolcapsule2.5 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinolcapsule5 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinolcapsule2.5 mgoralAbbott Laboratories, Limited1994-12-312012-02-24Canada
Marinolcapsule10 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinolcapsule5 mgoralAbbott Laboratories, Limited1994-12-312012-02-24Canada
Marinol Cap 10mgcapsule10 mgoralSolvay Pharma Inc1994-12-312008-07-24Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dronabinolcapsule5 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Dronabinolcapsule, liquid filled2.5 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule5 mg/1oralAmerican Health Packaging2010-09-07Not applicableUs
Dronabinolcapsule5 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Dronabinolcapsule10 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Dronabinolcapsule, liquid filled5 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule10 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Dronabinolcapsule5 mg/1oralPhysicians Total Care, Inc.2008-08-19Not applicableUs
Dronabinolcapsule, liquid filled10 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule2.5 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Dronabinolcapsule2.5 mg/1oralAmerican Health Packaging2010-09-07Not applicableUs
Dronabinolcapsule2.5 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
SativexGw Pharma Limited
SaltsNot Available
Categories
UNII7J8897W37S
CAS number1972-08-3
WeightAverage: 314.4617
Monoisotopic: 314.224580204
Chemical FormulaC21H30O2
InChI KeyInChIKey=CYQFCXCEBYINGO-IAGOWNOFSA-N
InChI
InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
IUPAC Name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
SMILES
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 2,2-dimethyl-1-benzopyrans. These are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzopyrans
Sub Class1-benzopyrans
Direct Parent2,2-dimethyl-1-benzopyrans
Alternative Parents
Substituents
  • 2,2-dimethyl-1-benzopyran
  • Alkyl aryl ether
  • Benzenoid
  • Oxacycle
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
PharmacodynamicsMarinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Mechanism of actionThe mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.
Related Articles
Absorption90 - 95%
Volume of distribution
  • 10 L/kg
Protein binding97%
Metabolism

Hepatic

SubstrateEnzymesProduct
Dronabinol
11-Hydroxy-delta-9-THCDetails
Dronabinol
7-beta-Hydroxy-delta-9-THCDetails
Dronabinol
7-alpha-Hydroxy-delta-9-THCDetails
Dronabinol
8-Hydroxy-delta-9-THCDetails
Dronabinol
8-beta-Hydroxy-delta-9-THCDetails
Dronabinol
9-alpha,10-alpha-epoxyhexahydrocannabinolDetails
8-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
11-Nor-9-carboxy-delta-9-THCDetails
Route of eliminationDronabinol and its biotransformation products are excreted in both feces and urine.
Half lifeAlpha phase: approximately 4 hours; Beta phase: 25-36 hours
Clearance
  • 0.2 L/kg-hr
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9949
Blood Brain Barrier+0.9685
Caco-2 permeable+0.7607
P-glycoprotein substrateSubstrate0.8458
P-glycoprotein inhibitor INon-inhibitor0.5548
P-glycoprotein inhibitor IIInhibitor0.7191
Renal organic cation transporterNon-inhibitor0.8169
CYP450 2C9 substrateNon-substrate0.7522
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7199
CYP450 1A2 substrateInhibitor0.6567
CYP450 2C9 inhibitorInhibitor0.5352
CYP450 2D6 inhibitorNon-inhibitor0.7307
CYP450 2C19 inhibitorInhibitor0.7683
CYP450 3A4 inhibitorNon-inhibitor0.6771
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8349
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8947
BiodegradationNot ready biodegradable0.9725
Rat acute toxicity2.5940 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7714
hERG inhibition (predictor II)Non-inhibitor0.8136
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Svc pharma lp
  • Abbott products inc
  • Roxane Laboratories,Inc.
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledoral10 mg/1
Capsule, liquid filledoral2.5 mg/1
Capsule, liquid filledoral5 mg/1
Capsuleoral10 mg/1
Capsuleoral2.5 mg/1
Capsuleoral2.5 mg
Capsuleoral5 mg
Capsuleoral5 mg/1
Capsuleoral10 mg
Spraybuccal
Prices
Unit descriptionCostUnit
Marinol 10 mg capsule29.86USD capsule
Dronabinol 10 mg capsule19.26USD capsule
Marinol 5 mg capsule16.0USD capsule
Dronabinol 5 mg capsule11.8USD capsule
Marinol 2.5 mg capsule8.02USD capsule
Dronabinol 2.5 mg capsule5.11USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6703418 No1994-02-262011-02-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point200 °C at 2.00E-02 mm HgNot Available
water solubility2800 mg/L (at 23 °C)NIH NTP Reports web-site
logP5.648Not Available
pKa10.6PHYSICIAN'S DESK REFERENCE (1998)
Predicted Properties
PropertyValueSource
Water Solubility0.00263 mg/mLALOGPS
logP7.29ALOGPS
logP5.94ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)9.34ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity96.73 m3·mol-1ChemAxon
Polarizability38.96 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-01pp-4792000000-06532e533cb7794b7c37View in MoNA
References
Synthesis Reference

Fabio E.S. SOUZA, Jason E. FIELD, Ming PAN, “INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL.” U.S. Patent US20080312465, issued December 18, 2008.

US20080312465
General ReferencesNot Available
External Links
ATC CodesA04AD10
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (51.4 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.
AbirateroneThe serum concentration of Dronabinol can be increased when it is combined with Abiraterone.
AcebutololDronabinol may increase the tachycardic activities of Acebutolol.
AcepromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
AceprometazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Dronabinol.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Dronabinol.
AclidiniumAclidinium may increase the tachycardic activities of Dronabinol.
adipiplonDronabinol may increase the central nervous system depressant (CNS depressant) activities of adipiplon.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Dronabinol.
AgomelatineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Agomelatine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Dronabinol.
AlfaxaloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfaxalone.
AlfentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Dronabinol.
AlphacetylmethadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alphacetylmethadol.
AlprazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Dronabinol.
AmiodaroneThe serum concentration of Dronabinol can be increased when it is combined with Amiodarone.
AmisulprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amisulpride.
AmitriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmperozideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amperozide.
AmphetamineDronabinol may increase the tachycardic activities of Amphetamine.
Anisotropine MethylbromideAnisotropine Methylbromide may increase the tachycardic activities of Dronabinol.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Dronabinol.
AprepitantThe serum concentration of Dronabinol can be increased when it is combined with Aprepitant.
AripiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
ArmodafinilThe metabolism of Dronabinol can be decreased when combined with Armodafinil.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Dronabinol.
ArticaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Articaine.
AsenapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
AtazanavirThe serum concentration of Dronabinol can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Dronabinol.
AtomoxetineThe serum concentration of Dronabinol can be increased when it is combined with Atomoxetine.
Atracurium besylateAtracurium besylate may increase the tachycardic activities of Dronabinol.
AtropineAtropine may increase the tachycardic activities of Dronabinol.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Dronabinol.
AzaperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Azaperone.
AzelastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
BarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Barbital.
BenactyzineBenactyzine may increase the tachycardic activities of Dronabinol.
BenzatropineBenzatropine may increase the tachycardic activities of Dronabinol.
BenzocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzocaine.
BenzphetamineDronabinol may increase the tachycardic activities of Benzphetamine.
Benzyl alcoholDronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Dronabinol.
BexaroteneThe serum concentration of Dronabinol can be decreased when it is combined with Bexarotene.
BiperidenBiperiden may increase the tachycardic activities of Dronabinol.
BoceprevirThe serum concentration of Dronabinol can be increased when it is combined with Boceprevir.
BortezomibThe serum concentration of Dronabinol can be increased when it is combined with Bortezomib.
BosentanThe serum concentration of Dronabinol can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Dronabinol.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Dronabinol.
BrexpiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrimonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Dronabinol.
BrompheniramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BrotizolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brotizolam.
BupivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bupivacaine.
BuprenorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
ButabarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butacaine.
ButalbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butalbital.
ButambenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butamben.
ButethalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butethal.
ButorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Dronabinol.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Dronabinol.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Dronabinol.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Dronabinol.
CapecitabineThe serum concentration of Dronabinol can be increased when it is combined with Capecitabine.
CarbamazepineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
CarbamazepineThe serum concentration of Dronabinol can be decreased when it is combined with Carbamazepine.
CarbinoxamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarfentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Dronabinol.
CarisoprodolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CeliprololDronabinol may increase the tachycardic activities of Celiprolol.
CeritinibThe serum concentration of Dronabinol can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Dronabinol.
CetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
Chloral hydrateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloral hydrate.
ChloramphenicolThe metabolism of Dronabinol can be decreased when combined with Chloramphenicol.
ChlordiazepoxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlormezanoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlormezanone.
ChloroprocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chloroprocaine.
ChlorphenamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorphenoxamineChlorphenoxamine may increase the tachycardic activities of Dronabinol.
ChlorphentermineDronabinol may increase the tachycardic activities of Chlorphentermine.
ChlorpromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorprothixeneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
ChlorzoxazoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
CholecalciferolThe serum concentration of Dronabinol can be increased when it is combined with Cholecalciferol.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Dronabinol.
CimetidineThe metabolism of Dronabinol can be decreased when combined with Cimetidine.
CinchocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cinchocaine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Dronabinol.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Dronabinol.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Dronabinol.
CitalopramThe metabolism of Dronabinol can be decreased when combined with Citalopram.
ClarithromycinThe serum concentration of Dronabinol can be increased when it is combined with Clarithromycin.
ClemastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClemastineThe serum concentration of Dronabinol can be increased when it is combined with Clemastine.
ClenbuterolDronabinol may increase the tachycardic activities of Clenbuterol.
ClidiniumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clidinium.
ClobazamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
clomethiazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of clomethiazole.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Dronabinol.
ClomipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClonazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Dronabinol.
ClorazepateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClotrimazoleThe serum concentration of Dronabinol can be increased when it is combined with Clotrimazole.
ClozapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
CobicistatThe serum concentration of Dronabinol can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Dronabinol.
CocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cocaine.
CocaineCocaine may increase the tachycardic activities of Dronabinol.
CodeineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Codeine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Dronabinol.
ConivaptanThe serum concentration of Dronabinol can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Dronabinol.
CrizotinibThe serum concentration of Dronabinol can be increased when it is combined with Crizotinib.
CyclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclobenzaprineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyclopentolateCyclopentolate may increase the tachycardic activities of Dronabinol.
CyclosporineThe serum concentration of Dronabinol can be increased when it is combined with Cyclosporine.
CyproheptadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Dronabinol.
DabrafenibThe serum concentration of Dronabinol can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Dronabinol.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Dronabinol.
DantroleneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Dronabinol.
DapiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dapiprazole.
DarifenacinDarifenacin may increase the tachycardic activities of Dronabinol.
DarunavirThe serum concentration of Dronabinol can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Dronabinol can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Dronabinol.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Dronabinol.
DeferasiroxThe serum concentration of Dronabinol can be decreased when it is combined with Deferasirox.
DelavirdineThe serum concentration of Dronabinol can be increased when it is combined with Delavirdine.
deramciclaneDronabinol may increase the central nervous system depressant (CNS depressant) activities of deramciclane.
DesfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesloratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
DesloratadineDesloratadine may increase the tachycardic activities of Dronabinol.
DetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Detomidine.
DexamethasoneThe serum concentration of Dronabinol can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Dronabinol.
DexbrompheniramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.
DexetimideDexetimide may increase the tachycardic activities of Dronabinol.
DexmedetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
DextromoramideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextromoramide.
DextropropoxypheneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.
DezocineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
DiazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DicyclomineDicyclomine may increase the tachycardic activities of Dronabinol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Dronabinol.
DifenoxinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Dronabinol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Dronabinol.
DihydrocodeineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydrocodeine.
DihydroergotamineThe serum concentration of Dronabinol can be increased when it is combined with Dihydroergotamine.
DihydroetorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydroetorphine.
DihydromorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dihydromorphine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dronabinol.
DiltiazemThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.
DimenhydrinateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DiphenhydramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DiphenoxylateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenoxylate.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Dronabinol.
DobutamineDronabinol may increase the tachycardic activities of Dobutamine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Dronabinol.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Dronabinol.
DopamineDronabinol may increase the tachycardic activities of Dopamine.
DoramectinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
DoxepinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Dronabinol.
DoxycyclineThe serum concentration of Dronabinol can be increased when it is combined with Doxycycline.
DoxylamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DPDPEDronabinol may increase the central nervous system depressant (CNS depressant) activities of DPDPE.
DronedaroneThe serum concentration of Dronabinol can be increased when it is combined with Dronedarone.
DroperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Droperidol.
DrotebanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Drotebanol.
DyclonineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
EcgonineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ecgonine.
ECGONINE METHYL ESTERDronabinol may increase the central nervous system depressant (CNS depressant) activities of ECGONINE METHYL ESTER.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Dronabinol.
EfavirenzDronabinol may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
EfavirenzThe serum concentration of Dronabinol can be increased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Dronabinol.
EnfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Enflurane.
EntacaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
EnzalutamideThe serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.
EphedrineDronabinol may increase the tachycardic activities of Ephedrine.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Dronabinol.
EpinephrineDronabinol may increase the tachycardic activities of Epinephrine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Dronabinol.
ErythromycinThe serum concentration of Dronabinol can be increased when it is combined with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Dronabinol can be decreased when it is combined with Eslicarbazepine acetate.
EsomeprazoleThe metabolism of Dronabinol can be decreased when combined with Esomeprazole.
EstazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Dronabinol.
EstriolThe serum concentration of Estriol can be increased when it is combined with Dronabinol.
EstroneThe serum concentration of Estrone can be increased when it is combined with Dronabinol.
EszopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EthanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthchlorvynolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Dronabinol.
EthopropazineEthopropazine may increase the tachycardic activities of Dronabinol.
EthosuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthotoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
Ethyl carbamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethyl carbamate.
Ethyl loflazepateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethyl loflazepate.
EthylmorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethylmorphine.
EtidocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etidocaine.
EtifoxineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
EtilefrineDronabinol may increase the tachycardic activities of Etilefrine.
EtizolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etizolam.
EtomidateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Dronabinol.
EtorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etorphine.
EtravirineThe serum concentration of Dronabinol can be increased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Dronabinol.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Dronabinol.
EzogabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
FelbamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FencamfamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fencamfamine.
FenoterolDronabinol may increase the tachycardic activities of Fenoterol.
FentanylDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FesoterodineFesoterodine may increase the tachycardic activities of Dronabinol.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Dronabinol.
FexofenadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Dronabinol.
FlibanserinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FloxuridineThe serum concentration of Dronabinol can be increased when it is combined with Floxuridine.
FluconazoleThe serum concentration of Dronabinol can be increased when it is combined with Fluconazole.
FludiazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fludiazepam.
FlunarizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FlunitrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunitrazepam.
FluorouracilThe serum concentration of Dronabinol can be increased when it is combined with Fluorouracil.
FluoxetineThe metabolism of Dronabinol can be decreased when combined with Fluoxetine.
FlupentixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.
FluphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FlurazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
FluspirileneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluspirilene.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Dronabinol.
Fluticasone PropionateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluticasone Propionate.
FluvastatinThe serum concentration of Dronabinol can be increased when it is combined with Fluvastatin.
FluvoxamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.
FluvoxamineThe serum concentration of Dronabinol can be increased when it is combined with Fluvoxamine.
FosamprenavirThe serum concentration of Dronabinol can be increased when it is combined with Fosamprenavir.
FosaprepitantThe serum concentration of Dronabinol can be increased when it is combined with Fosaprepitant.
FosphenytoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
FosphenytoinThe serum concentration of Dronabinol can be decreased when it is combined with Fosphenytoin.
FospropofolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fospropofol.
Fusidic AcidThe serum concentration of Dronabinol can be increased when it is combined with Fusidic Acid.
GabapentinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
gabapentin enacarbilDronabinol may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
Gallamine TriethiodideGallamine Triethiodide may increase the tachycardic activities of Dronabinol.
Gamma Hydroxybutyric AcidDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Dronabinol.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Dronabinol.
GemfibrozilThe serum concentration of Dronabinol can be increased when it is combined with Gemfibrozil.
GlutethimideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Glutethimide.
GlycopyrroniumGlycopyrronium may increase the tachycardic activities of Dronabinol.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Dronabinol.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Dronabinol.
GuanfacineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
HalazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
HaloperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HalothaneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Halothane.
HeroinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Heroin.
HexamethoniumHexamethonium may increase the tachycardic activities of Dronabinol.
HexobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hexobarbital.
HomatropineHomatropine may increase the tachycardic activities of Dronabinol.
HydrocodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Dronabinol.
HydromorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
Hydroxyamphetamine hydrobromideDronabinol may increase the tachycardic activities of Hydroxyamphetamine hydrobromide.
HydroxyzineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
HyoscyamineHyoscyamine may increase the tachycardic activities of Dronabinol.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Dronabinol.
IdelalisibThe serum concentration of Dronabinol can be increased when it is combined with Idelalisib.
IloperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
ImatinibThe serum concentration of Dronabinol can be increased when it is combined with Imatinib.
ImipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Dronabinol.
IndinavirThe serum concentration of Dronabinol can be increased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Dronabinol.
Ipratropium bromideIpratropium bromide may increase the tachycardic activities of Dronabinol.
IrbesartanThe serum concentration of Dronabinol can be increased when it is combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Dronabinol.
IsavuconazoniumThe serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium.
IsofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
IsoniazidThe metabolism of Dronabinol can be decreased when combined with Isoniazid.
IsoprenalineDronabinol may increase the tachycardic activities of Isoprenaline.
IsoxsuprineDronabinol may increase the tachycardic activities of Isoxsuprine.
IsradipineThe serum concentration of Dronabinol can be increased when it is combined with Isradipine.
ItraconazoleThe serum concentration of Dronabinol can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Dronabinol can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Dronabinol.
KetamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
KetazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketazolam.
KetobemidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketobemidone.
KetoconazoleThe serum concentration of Dronabinol can be increased when it is combined with Ketoconazole.
LabetalolDronabinol may increase the tachycardic activities of Labetalol.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Dronabinol.
LamotrigineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Dronabinol.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Dronabinol.
LeflunomideThe serum concentration of Dronabinol can be increased when it is combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Dronabinol.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Dronabinol.
LevetiracetamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevobupivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levobupivacaine.
LevocabastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevodopaDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Dronabinol.
Levomethadyl AcetateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levomethadyl Acetate.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Dronabinol.
LevorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LidocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Dronabinol.
LithiumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lithium.
LofentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lofentanil.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Dronabinol.
LopinavirThe serum concentration of Dronabinol can be increased when it is combined with Lopinavir.
LoratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LorazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LosartanThe serum concentration of Dronabinol can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Dronabinol can be increased when it is combined with Lovastatin.
LoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
Lu AA21004Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lu AA21004.
LuliconazoleThe serum concentration of Dronabinol can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Dronabinol can be decreased when it is combined with Lumacaftor.
LurasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Magnesium SulfateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Magnesium Sulfate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Dronabinol.
MaprotilineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MecamylamineMecamylamine may increase the tachycardic activities of Dronabinol.
MeclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MedetomidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Medetomidine.
MelatoninDronabinol may increase the central nervous system depressant (CNS depressant) activities of Melatonin.
MelperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Melperone.
MephentermineDronabinol may increase the tachycardic activities of Mephentermine.
MepivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mepivacaine.
MeprobamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MesoridazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mesoridazine.
MetaraminolDronabinol may increase the tachycardic activities of Metaraminol.
MetaxaloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MethadoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Methadyl AcetateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadyl Acetate.
MethamphetamineDronabinol may increase the tachycardic activities of Methamphetamine.
MethanthelineMethantheline may increase the tachycardic activities of Dronabinol.
MethapyrileneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methapyrilene.
MethaqualoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methaqualone.
MethocarbamolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethohexitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Dronabinol.
MethotrimeprazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethoxamineDronabinol may increase the tachycardic activities of Methoxamine.
MethoxyfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methoxyflurane.
MethsuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MethylphenobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methylphenobarbital.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Dronabinol.
MetixeneMetixene may increase the tachycardic activities of Dronabinol.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Dronabinol.
MidazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MidodrineDronabinol may increase the tachycardic activities of Midodrine.
MifepristoneThe serum concentration of Dronabinol can be increased when it is combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Dronabinol.
MirtazapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MitotaneThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Dronabinol.
MoclobemideThe metabolism of Dronabinol can be decreased when combined with Moclobemide.
ModafinilThe serum concentration of Dronabinol can be decreased when it is combined with Modafinil.
MolindoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Molindone.
MorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Dronabinol.
N-butylscopolammonium bromideN-butylscopolammonium bromide may increase the tachycardic activities of Dronabinol.
NabiloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nabilone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Dronabinol.
NafcillinThe serum concentration of Dronabinol can be decreased when it is combined with Nafcillin.
NalbuphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Dronabinol.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Dronabinol.
NefazodoneThe serum concentration of Dronabinol can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Dronabinol can be increased when it is combined with Nelfinavir.
NetupitantThe serum concentration of Dronabinol can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Dronabinol can be increased when it is combined with Nevirapine.
NicardipineThe serum concentration of Dronabinol can be increased when it is combined with Nicardipine.
NicotineThe metabolism of Dronabinol can be decreased when combined with Nicotine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Dronabinol.
NilotinibThe serum concentration of Dronabinol can be increased when it is combined with Nilotinib.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Dronabinol.
NitrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
Nitrous oxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Dronabinol.
NorepinephrineDronabinol may increase the tachycardic activities of Norepinephrine.
NormethadoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Normethadone.
NortriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
NVA237NVA237 may increase the tachycardic activities of Dronabinol.
NylidrinDronabinol may increase the tachycardic activities of Nylidrin.
OlanzapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlaparibThe serum concentration of Dronabinol can be increased when it is combined with Olaparib.
OlopatadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Dronabinol.
OmeprazoleThe serum concentration of Dronabinol can be increased when it is combined with Omeprazole.
OndansetronDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ondansetron.
OpiumDronabinol may increase the central nervous system depressant (CNS depressant) activities of Opium.
OrciprenalineDronabinol may increase the tachycardic activities of Orciprenaline.
OrphenadrineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineOrphenadrine may increase the tachycardic activities of Dronabinol.
OsanetantDronabinol may increase the central nervous system depressant (CNS depressant) activities of Osanetant.
OsimertinibThe serum concentration of Dronabinol can be increased when it is combined with Osimertinib.
OxazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxprenololDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxprenolol.
OxybuprocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxybuprocaine.
OxybutyninOxybutynin may increase the tachycardic activities of Dronabinol.
OxycodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxymetazolineDronabinol may increase the tachycardic activities of Oxymetazoline.
OxymorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
OxyphenoniumOxyphenonium may increase the tachycardic activities of Dronabinol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Dronabinol.
PalbociclibThe serum concentration of Dronabinol can be increased when it is combined with Palbociclib.
PaliperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
PancuroniumPancuronium may increase the tachycardic activities of Dronabinol.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Dronabinol.
PantoprazoleThe metabolism of Dronabinol can be decreased when combined with Pantoprazole.
ParaldehydeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Dronabinol.
PentazocineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PentobarbitalThe serum concentration of Dronabinol can be decreased when it is combined with Pentobarbital.
PentoliniumPentolinium may increase the tachycardic activities of Dronabinol.
PerampanelDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
PerospironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perospirone.
PerphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PethidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PhenmetrazineDronabinol may increase the tachycardic activities of Phenmetrazine.
PhenobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
PhenobarbitalThe serum concentration of Dronabinol can be decreased when it is combined with Phenobarbital.
PhenoxyethanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenoxyethanol.
PhentermineDronabinol may increase the tachycardic activities of Phentermine.
PhenylephrineDronabinol may increase the tachycardic activities of Phenylephrine.
PhenylpropanolamineDronabinol may increase the tachycardic activities of Phenylpropanolamine.
PhenytoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
PhenytoinThe serum concentration of Dronabinol can be decreased when it is combined with Phenytoin.
PimozideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
PipamperoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipamperone.
PipecuroniumPipecuronium may increase the tachycardic activities of Dronabinol.
PipotiazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PirenzepinePirenzepine may increase the tachycardic activities of Dronabinol.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Dronabinol.
PizotifenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
PomalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Dronabinol.
PosaconazoleThe serum concentration of Dronabinol can be increased when it is combined with Posaconazole.
PramocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pramocaine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Dronabinol.
PrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prazepam.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Dronabinol.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Dronabinol.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Dronabinol.
PregabalinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PrilocaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
PrimidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Primidone.
PrimidoneThe serum concentration of Dronabinol can be decreased when it is combined with Primidone.
ProcaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Procaine.
ProcaterolDronabinol may increase the tachycardic activities of Procaterol.
ProchlorperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
ProcyclidineProcyclidine may increase the tachycardic activities of Dronabinol.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Dronabinol.
PromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromethazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PropanthelinePropantheline may increase the tachycardic activities of Dronabinol.
ProparacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Proparacaine.
PropofolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propofol.
PropoxycaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propoxycaine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Dronabinol.
ProtriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Dronabinol.
PSD502Dronabinol may increase the central nervous system depressant (CNS depressant) activities of PSD502.
PseudoephedrineDronabinol may increase the tachycardic activities of Pseudoephedrine.
PyrimethamineThe serum concentration of Dronabinol can be increased when it is combined with Pyrimethamine.
QuazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
QuetiapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
QuinidineQuinidine may increase the tachycardic activities of Dronabinol.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Dronabinol.
QuinineThe serum concentration of Dronabinol can be increased when it is combined with Quinine.
RacepinephrineDronabinol may increase the tachycardic activities of Racepinephrine.
RamelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Dronabinol.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Dronabinol.
RemifentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
RemoxiprideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.
ReserpineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
RifabutinThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Dronabinol.
RifapentineThe serum concentration of Dronabinol can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Dronabinol.
RisperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RitodrineDronabinol may increase the tachycardic activities of Ritodrine.
RitonavirThe serum concentration of Dronabinol can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Dronabinol.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Dronabinol.
RomifidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Romifidine.
RopivacaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ropivacaine.
S-EthylisothioureaDronabinol may increase the central nervous system depressant (CNS depressant) activities of S-Ethylisothiourea.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Dronabinol.
SaquinavirThe serum concentration of Dronabinol can be increased when it is combined with Saquinavir.
ScopolamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
ScopolamineScopolamine may increase the tachycardic activities of Dronabinol.
Scopolamine butylbromideScopolamine butylbromide may increase the tachycardic activities of Dronabinol.
SecobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SecobarbitalThe metabolism of Dronabinol can be increased when combined with Secobarbital.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Dronabinol.
SertindoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertindole.
SertralineThe metabolism of Dronabinol can be decreased when combined with Sertraline.
SevofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
SildenafilThe serum concentration of Dronabinol can be increased when it is combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Dronabinol.
SiltuximabThe serum concentration of Dronabinol can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Dronabinol can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Dronabinol.
Sodium oxybateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Dronabinol.
SolifenacinSolifenacin may increase the tachycardic activities of Dronabinol.
SorafenibThe serum concentration of Dronabinol can be increased when it is combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Dronabinol.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Dronabinol.
St. John's WortThe serum concentration of Dronabinol can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Dronabinol can be increased when it is combined with Stiripentol.
StiripentolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
SufentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SulfadiazineThe serum concentration of Dronabinol can be increased when it is combined with Sulfadiazine.
SulfamethoxazoleThe serum concentration of Dronabinol can be increased when it is combined with Sulfamethoxazole.
SulfisoxazoleThe serum concentration of Dronabinol can be increased when it is combined with Sulfisoxazole.
SulpirideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
SuvorexantDronabinol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
SynephrineDronabinol may increase the tachycardic activities of Synephrine.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Dronabinol.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Dronabinol.
TapentadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
TasimelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Dronabinol.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronabinol.
TelaprevirThe serum concentration of Dronabinol can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Dronabinol can be increased when it is combined with Telithromycin.
TemazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Dronabinol.
TerbutalineDronabinol may increase the tachycardic activities of Terbutaline.
TetrabenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.
TetracaineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetracaine.
TetrodotoxinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrodotoxin.
TetryzolineDronabinol may increase the tachycardic activities of Tetryzoline.
ThalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThiamylalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiamylal.
ThiopentalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiopental.
ThioridazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
ThiothixeneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
TiagabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TicagrelorThe serum concentration of Dronabinol can be increased when it is combined with Ticagrelor.
TiclopidineThe serum concentration of Dronabinol can be increased when it is combined with Ticlopidine.
TiletamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiletamine.
TimololThe serum concentration of Timolol can be increased when it is combined with Dronabinol.
TiotropiumTiotropium may increase the tachycardic activities of Dronabinol.
TizanidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TocilizumabThe serum concentration of Dronabinol can be decreased when it is combined with Tocilizumab.
TolbutamideThe serum concentration of Dronabinol can be increased when it is combined with Tolbutamide.
TolcaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TolterodineTolterodine may increase the tachycardic activities of Dronabinol.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Dronabinol.
TopiramateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TopiramateThe metabolism of Dronabinol can be decreased when combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Dronabinol.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Dronabinol.
TramadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
Trans-2-PhenylcyclopropylamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trans-2-Phenylcyclopropylamine.
TranylcypromineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tranylcypromine.
TranylcypromineThe metabolism of Dronabinol can be decreased when combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Dronabinol.
TrazodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
TriazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TrifluoperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TriflupromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.
TrihexyphenidylTrihexyphenidyl may increase the tachycardic activities of Dronabinol.
TrimethaphanTrimethaphan may increase the tachycardic activities of Dronabinol.
TrimethoprimThe serum concentration of Dronabinol can be increased when it is combined with Trimethoprim.
TrimipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TriprolidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
TropicamideTropicamide may increase the tachycardic activities of Dronabinol.
TrospiumTrospium may increase the tachycardic activities of Dronabinol.
TubocurarineTubocurarine may increase the tachycardic activities of Dronabinol.
TyramineDronabinol may increase the tachycardic activities of Tyramine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Dronabinol.
UmeclidiniumUmeclidinium may increase the tachycardic activities of Dronabinol.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Dronabinol.
Valproic AcidDronabinol may increase the central nervous system depressant (CNS depressant) activities of Valproic Acid.
Valproic AcidThe serum concentration of Dronabinol can be increased when it is combined with Valproic Acid.
ValsartanThe serum concentration of Dronabinol can be increased when it is combined with Valsartan.
VecuroniumVecuronium may increase the tachycardic activities of Dronabinol.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Dronabinol.
VenlafaxineThe serum concentration of Dronabinol can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Dronabinol can be increased when it is combined with Verapamil.
VigabatrinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Dronabinol.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Dronabinol.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Dronabinol.
VoriconazoleThe serum concentration of Dronabinol can be increased when it is combined with Voriconazole.
VortioxetineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Vortioxetine.
XylazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Xylazine.
ZafirlukastThe serum concentration of Dronabinol can be increased when it is combined with Zafirlukast.
ZaleplonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZiconotideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Dronabinol.
ZiprasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
ZiprasidoneThe serum concentration of Dronabinol can be increased when it is combined with Ziprasidone.
ZolazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
ZolpidemDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZonisamideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
ZotepineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zotepine.
ZuclopenthixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Drug binding
Specific Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Gene Name:
CNR1
Uniprot ID:
P21554
Molecular Weight:
52857.365 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Pryce G, Giovannoni G, Baker D: Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice. Neurosci Lett. 2003 May 1;341(2):164-6. [PubMed:12686391 ]
  4. Tsai SJ, Wang YC, Hong CJ: Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. Psychiatr Genet. 2000 Sep;10(3):149-51. [PubMed:11204352 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Cannabinoid receptor activity
Specific Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Gene Name:
CNR2
Uniprot ID:
P34972
Molecular Weight:
39680.275 Da
References
  1. Davis M, Maida V, Daeninck P, Pergolizzi J: The emerging role of cannabinoid neuromodulators in symptom management. Support Care Cancer. 2007 Jan;15(1):63-71. Epub 2006 Dec 1. [PubMed:17139494 ]
  2. Pertwee RG: Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411. doi: 10.1111/j.1476-5381.2008.00048.x. [PubMed:19226257 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23