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Identification
NameDronabinol
Accession NumberDB00470  (APRD00571)
TypeSmall Molecule
GroupsApproved, Illicit
Description

A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC. [PubChem]

Structure
Thumb
Synonyms
(-)-delta9-trans-Tetrahydrocannabinol
1-trans-delta-9-Tetrahydrocannabinol
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
delta-9-tetrahydrocannabinol
delta-9-THC
delta(1)-Tetrahydrocannabinol
delta(9)-THC
delta9-Tetrahydrocannabinol
Dronabinol
Dronabinolum
Tetrahydrocannabinol
Δ9-tetrahydrocannabinol
External Identifiers
  • Abbott 40566
  • Dea No. 7369
  • Dea No. 7370
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dronabinolcapsule2.5 mg/1oralActavis Pharma, Inc.1994-08-11Not applicableUs
Dronabinolcapsule10 mg/1oralActavis Pharma, Inc.1994-08-11Not applicableUs
Dronabinolcapsule5 mg/1oralActavis Pharma, Inc.2005-06-07Not applicableUs
Marinolcapsule2.5 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinolcapsule2.5 mgoralAbbott Laboratories, Limited1994-12-312012-02-24Canada
Marinolcapsule5 mgoralAbbott Laboratories, Limited1994-12-312012-02-24Canada
Marinolcapsule10 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinolcapsule5 mg/1oralAbb Vie Inc.2010-07-13Not applicableUs
Marinol Cap 10mgcapsule10 mgoralSolvay Pharma Inc1994-12-312008-07-24Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dronabinolcapsule, liquid filled2.5 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule2.5 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Dronabinolcapsule10 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Dronabinolcapsule5 mg/1oralAmerican Health Packaging2010-09-07Not applicableUs
Dronabinolcapsule5 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Dronabinolcapsule2.5 mg/1oralAmerican Health Packaging2010-09-07Not applicableUs
Dronabinolcapsule2.5 mg/1oralAkorn, Inc.2014-06-20Not applicableUs
Dronabinolcapsule5 mg/1oralPhysicians Total Care, Inc.2008-08-19Not applicableUs
Dronabinolcapsule, liquid filled10 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule10 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Dronabinolcapsule, liquid filled5 mg/1oralMylan Pharmaceuticals Inc.2011-11-01Not applicableUs
Dronabinolcapsule5 mg/1oralPar Pharmaceutical Inc.2008-06-27Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
SativexGw Pharma Limited
SaltsNot Available
CategoriesNot Available
UNII7J8897W37S
CAS number1972-08-3
WeightAverage: 314.4617
Monoisotopic: 314.224580204
Chemical FormulaC21H30O2
InChI KeyInChIKey=CYQFCXCEBYINGO-IAGOWNOFSA-N
InChI
InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
IUPAC Name
(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol
SMILES
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 2,2-dimethyl-1-benzopyrans. These are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzopyrans
Sub Class1-benzopyrans
Direct Parent2,2-dimethyl-1-benzopyrans
Alternative Parents
Substituents
  • 2,2-dimethyl-1-benzopyran
  • Alkyl aryl ether
  • Benzenoid
  • Oxacycle
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
PharmacodynamicsMarinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Mechanism of actionThe mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.
Related Articles
Absorption90 - 95%
Volume of distribution
  • 10 L/kg
Protein binding97%
Metabolism

Hepatic

SubstrateEnzymesProduct
Dronabinol
11-Hydroxy-delta-9-THCDetails
Dronabinol
7-beta-Hydroxy-delta-9-THCDetails
Dronabinol
7-alpha-Hydroxy-delta-9-THCDetails
Dronabinol
8-Hydroxy-delta-9-THCDetails
Dronabinol
8-beta-Hydroxy-delta-9-THCDetails
Dronabinol
9-alpha,10-alpha-epoxyhexahydrocannabinolDetails
8-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
8,11-Dihydroxy-delta-9-THCDetails
11-Hydroxy-delta-9-THC
Not Available
11-Nor-9-carboxy-delta-9-THCDetails
Route of eliminationDronabinol and its biotransformation products are excreted in both feces and urine.
Half lifeAlpha phase: approximately 4 hours; Beta phase: 25-36 hours
Clearance
  • 0.2 L/kg-hr
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9949
Blood Brain Barrier+0.9685
Caco-2 permeable+0.7607
P-glycoprotein substrateSubstrate0.8458
P-glycoprotein inhibitor INon-inhibitor0.5548
P-glycoprotein inhibitor IIInhibitor0.7191
Renal organic cation transporterNon-inhibitor0.8169
CYP450 2C9 substrateNon-substrate0.7522
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.7199
CYP450 1A2 substrateInhibitor0.6567
CYP450 2C9 inhibitorInhibitor0.5352
CYP450 2D6 inhibitorNon-inhibitor0.7307
CYP450 2C19 inhibitorInhibitor0.7683
CYP450 3A4 inhibitorNon-inhibitor0.6771
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8349
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.8947
BiodegradationNot ready biodegradable0.9725
Rat acute toxicity2.5940 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7714
hERG inhibition (predictor II)Non-inhibitor0.8136
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Svc pharma lp
  • Abbott products inc
  • Roxane Laboratories,Inc.
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledoral10 mg/1
Capsule, liquid filledoral2.5 mg/1
Capsule, liquid filledoral5 mg/1
Capsuleoral10 mg/1
Capsuleoral2.5 mg/1
Capsuleoral2.5 mg
Capsuleoral5 mg
Capsuleoral5 mg/1
Capsuleoral10 mg
Spraybuccal
Prices
Unit descriptionCostUnit
Marinol 10 mg capsule29.86USD capsule
Dronabinol 10 mg capsule19.26USD capsule
Marinol 5 mg capsule16.0USD capsule
Dronabinol 5 mg capsule11.8USD capsule
Marinol 2.5 mg capsule8.02USD capsule
Dronabinol 2.5 mg capsule5.11USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6703418 No1994-02-262011-02-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point200 °C at 2.00E-02 mm HgNot Available
water solubility2800 mg/L (at 23 °C)NIH NTP Reports web-site
logP5.648Not Available
pKa10.6PHYSICIAN'S DESK REFERENCE (1998)
Predicted Properties
PropertyValueSource
Water Solubility0.00263 mg/mLALOGPS
logP7.29ALOGPS
logP5.94ChemAxon
logS-5.1ALOGPS
pKa (Strongest Acidic)9.34ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area29.46 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity96.73 m3·mol-1ChemAxon
Polarizability38.96 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-01pp-4792000000-06532e533cb7794b7c37View in MoNA
References
Synthesis Reference

Fabio E.S. SOUZA, Jason E. FIELD, Ming PAN, “INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL.” U.S. Patent US20080312465, issued December 18, 2008.

US20080312465
General ReferencesNot Available
External Links
ATC CodesA04AD10
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (51.4 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Dronabinol can be increased when it is combined with Abiraterone.
AcebutololDronabinol may increase the tachycardic activities of Acebutolol.
AcetaminophenDronabinol may increase the tachycardic activities of Acetaminophen.
AclidiniumAclidinium may increase the tachycardic activities of Dronabinol.
AlfentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlprazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AminophyllineDronabinol may increase the tachycardic activities of Aminophylline.
AmiodaroneThe serum concentration of Dronabinol can be increased when it is combined with Amiodarone.
AmitriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmphetamineDronabinol may increase the tachycardic activities of Amphetamine.
AprepitantThe serum concentration of Dronabinol can be increased when it is combined with Aprepitant.
ArformoterolDronabinol may increase the tachycardic activities of Arformoterol.
AripiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
ArmodafinilDronabinol may increase the tachycardic activities of Armodafinil.
ArticaineDronabinol may increase the tachycardic activities of Articaine.
AsenapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
AtazanavirThe serum concentration of Dronabinol can be increased when it is combined with Atazanavir.
AtropineAtropine may increase the tachycardic activities of Dronabinol.
AzelastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
BenzatropineBenzatropine may increase the tachycardic activities of Dronabinol.
BenzphetamineDronabinol may increase the tachycardic activities of Benzphetamine.
BoceprevirThe serum concentration of Dronabinol can be increased when it is combined with Boceprevir.
BrexpiprazoleDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrimonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BrompheniramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BuprenorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
ButabarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
CaffeineDronabinol may increase the tachycardic activities of Caffeine.
CapecitabineThe serum concentration of Dronabinol can be increased when it is combined with Capecitabine.
CarbamazepineThe serum concentration of Dronabinol can be decreased when it is combined with Carbamazepine.
CarbinoxamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarisoprodolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CeritinibThe serum concentration of Dronabinol can be increased when it is combined with Ceritinib.
CetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
ChlordiazepoxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlorphenamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorphentermineDronabinol may increase the tachycardic activities of Chlorphentermine.
ChlorpromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorzoxazoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
ClarithromycinThe serum concentration of Dronabinol can be increased when it is combined with Clarithromycin.
ClemastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClenbuterolDronabinol may increase the tachycardic activities of Clenbuterol.
ClobazamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
ClomipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClonazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClorazepateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClozapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
CobicistatThe serum concentration of Dronabinol can be increased when it is combined with Cobicistat.
CocaineCocaine may increase the tachycardic activities of Dronabinol.
ConivaptanThe serum concentration of Dronabinol can be increased when it is combined with Conivaptan.
CrizotinibThe serum concentration of Dronabinol can be increased when it is combined with Crizotinib.
CyclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclobenzaprineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyclopentolateCyclopentolate may increase the tachycardic activities of Dronabinol.
CyproheptadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DantroleneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DarifenacinDarifenacin may increase the tachycardic activities of Dronabinol.
DarunavirThe serum concentration of Dronabinol can be increased when it is combined with Darunavir.
DelavirdineThe serum concentration of Dronabinol can be increased when it is combined with Delavirdine.
DesfluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesloratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Dexchlorpheniramine maleateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dexchlorpheniramine maleate.
DexmethylphenidateDronabinol may increase the tachycardic activities of Dexmethylphenidate.
DextroamphetamineDronabinol may increase the tachycardic activities of Dextroamphetamine.
DiazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DicyclomineDicyclomine may increase the tachycardic activities of Dronabinol.
DiethylpropionDronabinol may increase the tachycardic activities of Diethylpropion.
DiltiazemThe serum concentration of Dronabinol can be increased when it is combined with Diltiazem.
DimenhydrinateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DiphenhydramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DipivefrinDronabinol may increase the tachycardic activities of Dipivefrin.
DisopyramideDisopyramide may increase the tachycardic activities of Dronabinol.
DobutamineDronabinol may increase the tachycardic activities of Dobutamine.
DopamineDronabinol may increase the tachycardic activities of Dopamine.
DoxapramDronabinol may increase the tachycardic activities of Doxapram.
DoxepinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DoxylamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DronedaroneThe serum concentration of Dronabinol can be increased when it is combined with Dronedarone.
DroperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Droperidol.
DyphyllineDronabinol may increase the tachycardic activities of Dyphylline.
EfavirenzThe serum concentration of Dronabinol can be increased when it is combined with Efavirenz.
EntacaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
EnzalutamideThe serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.
EphedrineDronabinol may increase the tachycardic activities of Ephedrine.
EpinephrineDronabinol may increase the tachycardic activities of Epinephrine.
ErythromycinThe serum concentration of Dronabinol can be increased when it is combined with Erythromycin.
EstazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EszopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EthanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthosuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthotoinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
EtravirineThe serum concentration of Dronabinol can be increased when it is combined with Etravirine.
EzogabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
FelbamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FenoterolDronabinol may increase the tachycardic activities of Fenoterol.
FentanylDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FesoterodineFesoterodine may increase the tachycardic activities of Dronabinol.
FexofenadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FlavoxateFlavoxate may increase the tachycardic activities of Dronabinol.
FlibanserinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FloxuridineThe serum concentration of Dronabinol can be increased when it is combined with Floxuridine.
FluconazoleThe serum concentration of Dronabinol can be increased when it is combined with Fluconazole.
FlunarizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FluorouracilThe serum concentration of Dronabinol can be increased when it is combined with Fluorouracil.
FlupentixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.
FluphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FlurazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
Fluticasone PropionateDronabinol may increase the tachycardic activities of Fluticasone Propionate.
FluvastatinThe serum concentration of Dronabinol can be increased when it is combined with Fluvastatin.
FormoterolDronabinol may increase the tachycardic activities of Formoterol.
FosamprenavirThe serum concentration of Dronabinol can be increased when it is combined with Fosamprenavir.
FosphenytoinThe serum concentration of Dronabinol can be decreased when it is combined with Fosphenytoin.
GabapentinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
gabapentin enacarbilDronabinol may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
Gamma Hydroxybutyric AcidDronabinol may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.
GemfibrozilThe serum concentration of Dronabinol can be increased when it is combined with Gemfibrozil.
GlycopyrroniumGlycopyrrolate may increase the tachycardic activities of Dronabinol.
GuanfacineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
HaloperidolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HomatropineHomatropine may increase the tachycardic activities of Dronabinol.
HydrocodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydromorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
HydroxyzineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
HyoscyamineHyoscyamine may increase the tachycardic activities of Dronabinol.
IdelalisibThe serum concentration of Dronabinol can be increased when it is combined with Idelalisib.
IloperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
ImatinibThe serum concentration of Dronabinol can be increased when it is combined with Imatinib.
ImipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
IndacaterolDronabinol may increase the tachycardic activities of Indacaterol.
IndinavirThe serum concentration of Dronabinol can be increased when it is combined with Indinavir.
Ipratropium bromideIpratropium bromide may increase the tachycardic activities of Dronabinol.
IrbesartanThe serum concentration of Dronabinol can be increased when it is combined with Irbesartan.
IsavuconazoniumThe serum concentration of Dronabinol can be increased when it is combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the tachycardic activities of Dronabinol.
IsofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
IsomethepteneDronabinol may increase the tachycardic activities of Isometheptene.
IsoprenalineDronabinol may increase the tachycardic activities of Isoprenaline.
ItraconazoleThe serum concentration of Dronabinol can be increased when it is combined with Itraconazole.
KetamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
KetoconazoleThe serum concentration of Dronabinol can be increased when it is combined with Ketoconazole.
LabetalolDronabinol may increase the tachycardic activities of Labetalol.
LamotrigineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LeflunomideThe serum concentration of Dronabinol can be increased when it is combined with Leflunomide.
LevetiracetamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevocabastineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocetirizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevonordefrinDronabinol may increase the tachycardic activities of Levonordefrin.
LevorphanolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LisdexamfetamineDronabinol may increase the tachycardic activities of Lisdexamfetamine.
LoratadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LorazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LosartanThe serum concentration of Dronabinol can be increased when it is combined with Losartan.
LoxapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
LurasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
MaprotilineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MeclizineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MepenzolateMepenzolate may increase the tachycardic activities of Dronabinol.
MephentermineDronabinol may increase the tachycardic activities of Mephentermine.
MepivacaineDronabinol may increase the tachycardic activities of Mepivacaine.
MeprobamateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MetaraminolDronabinol may increase the tachycardic activities of Metaraminol.
MetaxaloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MethadoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethamphetamineDronabinol may increase the tachycardic activities of Methamphetamine.
MethocarbamolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethohexitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethotrimeprazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethoxamineDronabinol may increase the tachycardic activities of Methoxamine.
MethscopolamineMethscopolamine may increase the tachycardic activities of Dronabinol.
MethsuximideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MethylphenidateDronabinol may increase the tachycardic activities of Methylphenidate.
MidazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MidodrineDronabinol may increase the tachycardic activities of Midodrine.
MifepristoneThe serum concentration of Dronabinol can be increased when it is combined with Mifepristone.
MirtazapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MitotaneThe serum concentration of Dronabinol can be decreased when it is combined with Mitotane.
MoclobemideMoclobemide may increase the tachycardic activities of Dronabinol.
ModafinilDronabinol may increase the tachycardic activities of Modafinil.
MorphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Morphine.
NalbuphineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NaphazolineDronabinol may increase the tachycardic activities of Naphazoline.
NefazodoneThe serum concentration of Dronabinol can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Dronabinol can be increased when it is combined with Nelfinavir.
NicardipineThe serum concentration of Dronabinol can be increased when it is combined with Nicardipine.
NilotinibThe serum concentration of Dronabinol can be increased when it is combined with Nilotinib.
NitrazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
Nitrous oxideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
NorepinephrineDronabinol may increase the tachycardic activities of Norepinephrine.
NortriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
OlanzapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlodaterolDronabinol may increase the tachycardic activities of Olodaterol.
OlopatadineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OmeprazoleThe serum concentration of Dronabinol can be increased when it is combined with Omeprazole.
OrciprenalineDronabinol may increase the tachycardic activities of Orciprenaline.
OrphenadrineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OxazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxybutyninOxybutynin may increase the tachycardic activities of Dronabinol.
OxycodoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxymetazolineDronabinol may increase the tachycardic activities of Oxymetazoline.
OxymorphoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
PaliperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
ParaldehydeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
PentazocineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PerampanelDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
PerphenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PethidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PhendimetrazineDronabinol may increase the tachycardic activities of Phendimetrazine.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Dronabinol.
PheniramineDronabinol may increase the tachycardic activities of Pheniramine.
PhenmetrazineDronabinol may increase the tachycardic activities of Phenmetrazine.
PhenobarbitalThe serum concentration of Dronabinol can be decreased when it is combined with Phenobarbital.
PhentermineDronabinol may increase the tachycardic activities of Phentermine.
PhenylephrineDronabinol may increase the tachycardic activities of Phenylephrine.
PhenylpropanolamineDronabinol may increase the tachycardic activities of Phenylpropanolamine.
PhenytoinThe serum concentration of Dronabinol can be decreased when it is combined with Phenytoin.
PimozideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
PipotiazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PirbuterolDronabinol may increase the tachycardic activities of Pirbuterol.
PizotifenDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
PomalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
PosaconazoleThe serum concentration of Dronabinol can be increased when it is combined with Posaconazole.
PregabalinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PrimidoneThe serum concentration of Dronabinol can be decreased when it is combined with Primidone.
ProchlorperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
ProcyclidineProcyclidine may increase the tachycardic activities of Dronabinol.
PromazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromethazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PropanthelinePropantheline may increase the tachycardic activities of Dronabinol.
PropofolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Propofol.
PropylhexedrineDronabinol may increase the tachycardic activities of Propylhexedrine.
ProtriptylineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
PseudoephedrineDronabinol may increase the tachycardic activities of Pseudoephedrine.
PyrimethamineThe serum concentration of Dronabinol can be increased when it is combined with Pyrimethamine.
QuazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
QuetiapineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
QuinineThe serum concentration of Dronabinol can be increased when it is combined with Quinine.
RacepinephrineDronabinol may increase the tachycardic activities of Racepinephrine.
RamelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RemifentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
ReserpineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
RifabutinThe serum concentration of Dronabinol can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Dronabinol can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Dronabinol can be decreased when it is combined with Rifapentine.
RisperidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RitodrineDronabinol may increase the tachycardic activities of Ritodrine.
RitonavirThe serum concentration of Dronabinol can be increased when it is combined with Ritonavir.
SalbutamolDronabinol may increase the tachycardic activities of Salbutamol.
SalmeterolDronabinol may increase the tachycardic activities of Salmeterol.
SaquinavirThe serum concentration of Dronabinol can be increased when it is combined with Saquinavir.
ScopolamineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
Scopolamine butylbromideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Scopolamine butylbromide.
SecobarbitalDronabinol may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SevofluraneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
Sodium oxybateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
SolifenacinSolifenacin may increase the tachycardic activities of Dronabinol.
SorafenibThe serum concentration of Dronabinol can be increased when it is combined with Sorafenib.
StiripentolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
SufentanilDronabinol may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SulfadiazineThe serum concentration of Dronabinol can be increased when it is combined with Sulfadiazine.
SulfisoxazoleThe serum concentration of Dronabinol can be increased when it is combined with Sulfisoxazole.
SuvorexantDronabinol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TapentadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
TasimelteonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
TelaprevirThe serum concentration of Dronabinol can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Dronabinol can be increased when it is combined with Telithromycin.
TemazepamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
TerbutalineDronabinol may increase the tachycardic activities of Terbutaline.
TetrabenazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.
ThalidomideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TheophyllineDronabinol may increase the tachycardic activities of Theophylline.
ThioridazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
ThiothixeneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
TiagabineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TicagrelorThe serum concentration of Dronabinol can be increased when it is combined with Ticagrelor.
TiotropiumTiotropium may increase the tachycardic activities of Dronabinol.
TizanidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TolbutamideThe serum concentration of Dronabinol can be increased when it is combined with Tolbutamide.
TolcaponeDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TolterodineTolterodine may increase the tachycardic activities of Dronabinol.
TopiramateDronabinol may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TramadolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Dronabinol.
TriazolamDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TrifluoperazineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TrihexyphenidylTrihexyphenidyl may increase the tachycardic activities of Dronabinol.
TrimethobenzamideTrimethobenzamide may increase the tachycardic activities of Dronabinol.
TrimethoprimThe serum concentration of Dronabinol can be increased when it is combined with Trimethoprim.
TrimipramineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TriprolidineDronabinol may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
TrospiumTrospium may increase the tachycardic activities of Dronabinol.
UmeclidiniumUmeclidinium may increase the tachycardic activities of Dronabinol.
VerapamilThe serum concentration of Dronabinol can be increased when it is combined with Verapamil.
VigabatrinDronabinol may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
VilanterolDronabinol may increase the tachycardic activities of Vilanterol.
VoriconazoleThe serum concentration of Dronabinol can be increased when it is combined with Voriconazole.
ZafirlukastThe serum concentration of Dronabinol can be increased when it is combined with Zafirlukast.
ZaleplonDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZiconotideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZiprasidoneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
ZolpidemDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZonisamideDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZopicloneDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
ZuclopenthixolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.
Food Interactions
  • Avoid alcohol.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Drug binding
Specific Function:
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Gene Name:
CNR1
Uniprot ID:
P21554
Molecular Weight:
52857.365 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Pryce G, Giovannoni G, Baker D: Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice. Neurosci Lett. 2003 May 1;341(2):164-6. [PubMed:12686391 ]
  4. Tsai SJ, Wang YC, Hong CJ: Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia. Psychiatr Genet. 2000 Sep;10(3):149-51. [PubMed:11204352 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Cannabinoid receptor activity
Specific Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Gene Name:
CNR2
Uniprot ID:
P34972
Molecular Weight:
39680.275 Da
References
  1. Davis M, Maida V, Daeninck P, Pergolizzi J: The emerging role of cannabinoid neuromodulators in symptom management. Support Care Cancer. 2007 Jan;15(1):63-71. Epub 2006 Dec 1. [PubMed:17139494 ]
  2. Pertwee RG: Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411. doi: 10.1111/j.1476-5381.2008.00048.x. [PubMed:19226257 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Tournier N, Chevillard L, Megarbane B, Pirnay S, Scherrmann JM, Decleves X: Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. doi: 10.1017/S1461145709990848. Epub 2009 Nov 4. [PubMed:19887017 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23