Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.

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Letavic MA, Keith JM, Ly KS, Barbier AJ, Boggs JD, Wilson SJ, Lord B, Lovenberg TW, Carruthers NI

Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.

Bioorg Med Chem Lett. 2007 May 1;17(9):2566-9. Epub 2007 Feb 4.

PubMed ID

17307358 [ View in PubMed

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Abstract

A series of novel tetrahydronaphthyridine-based histamine H(3) ligands that have serotonin reuptake transporter inhibitor activity is described. The 1,2,3,4-tetrahydro-2,6-naphthyridine scaffold is assembled via the addition of a nitrostyrene to a metalated pyridine followed by reduction and cyclization to form the naphthyridine. In vitro biological data for these novel compounds are discussed.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Fluoxetine	Sodium-dependent serotonin transporter	Ki (nM)	2.2	N/A	N/A	Details