Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.

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Bymaster FP, Beedle EE, Findlay J, Gallagher PT, Krushinski JH, Mitchell S, Robertson DW, Thompson DC, Wallace L, Wong DT

Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4477-80.

PubMed ID

14643350 [ View in PubMed

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Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Duloxetine	Sodium-dependent dopamine transporter	Ki (nM)	240	N/A	N/A	Details
Duloxetine	Sodium-dependent noradrenaline transporter	Ki (nM)	7.5	N/A	N/A	Details
Duloxetine	Sodium-dependent serotonin transporter	Ki (nM)	0.8	N/A	N/A	Details