Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.

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Leopoldo M, Lacivita E, De Giorgio P, Contino M, Berardi F, Perrone R

Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.

Bioorg Med Chem. 2009 Jan 15;17(2):758-66. doi: 10.1016/j.bmc.2008.11.044. Epub 2008 Nov 24.

PubMed ID
19081257 [ View in PubMed
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Abstract

In the search for compounds with potential for development as positron emission tomography radioligands for brain D(3) receptor imaging, a series of N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides with appropriate lipophilicity (2

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
HaloperidolDopamine D2 receptorKi (nM)4.2N/AN/ADetails