Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.

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Deng S, Palu 'K, West BJ, Su CX, Zhou BN, Jensen JC

Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.

J Nat Prod. 2007 May;70(5):859-62. Epub 2007 Mar 23.

PubMed ID

17378609 [ View in PubMed

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Abstract

A phytochemical study of the fruits of noni (Morinda citrifolia) collected in Tahiti led to the isolation of two new lignans, (+)-3,4,3',4'-tetrahydroxy-9,7'alpha-epoxylignano-7 alpha,9'-lactone (1) and (+)-3,3'-bisdemethyltanegool (2), as well as seven known compounds, (-)-pinoresinol (3), (-)-3,3'-bisdemethylpinoresinol (4), quercetin (5), kaempferol (6), scopoletin (7), isoscopoletin (8), and vanillin. The structures of 1 and 2 were determined by spectroscopic techniques. Compounds 3, 6, and 8 were isolated for the first time from noni fruit. Compounds 1-8 were shown to inhibit 5- and/or 15-lipoxygenase, with IC50 values ranging from 0.43 to 16.5 microM. Compound 5 exhibited weak inhibitory activity toward cyclooxygenase-2.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rofecoxib	Prostaglandin G/H synthase 2	IC 50 (nM)	120	N/A	N/A	Details