New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics.
Article Details
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Hauck SI, Cederberg C, Doucette A, Grosser L, Hales NJ, Poon G, Gravestock MB
New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):337-40. Epub 2006 Oct 26.
- PubMed ID
- 17095223 [ View in PubMed]
- Abstract
Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazole diminished monoamine oxidase activity. The synthesis and biological evaluation of these compounds are reported.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Linezolid Amine oxidase [flavin-containing] A Ki (nM) 20000 N/A N/A Details