Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.

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Rachid Z, Katsoulas A, Brahimi F, Jean-Claude BJ

Synthesis of pyrimidinopyridine-triazene conjugates targeted to abl tyrosine kinase.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3297-300.

PubMed ID

12951113 [ View in PubMed

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Abstract

The synthesis and abl tyrosine kinase inhibitory activities of alkyltriazenes conjugated to phenylaminopyrimidines are described. Significant abl inhibitory activities were observed only when a benzamido spacer was inserted between the 1,2,3-triazene chain and the 2-phenyaminopyridopyrimidine moiety.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Imatinib	Tyrosine-protein kinase ABL1	IC 50 (nM)	40	N/A	N/A	Details