Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.

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MacLeod AM, Street LJ, Reeve AJ, Jelley RA, Sternfeld F, Beer MS, Stanton JA, Watt AP, Rathbone D, Matassa VG

Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents.

J Med Chem. 1997 Oct 24;40(22):3501-3.

PubMed ID

9357515 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Sumatriptan	5-hydroxytryptamine receptor 1B	IC 50 (nM)	16	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1B	IC 50 (nM)	27	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	EC 50 (nM)	16	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	IC 50 (nM)	5	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	IC 50 (nM)	2400	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1F	IC 50 (nM)	>1000	N/A	N/A	Details