Isoquinoline derivatives as potential acetylcholinesterase inhibitors.
Article Details
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Markmee S, Ruchirawat S, Prachyawarakorn V, Ingkaninan K, Khorana N
Isoquinoline derivatives as potential acetylcholinesterase inhibitors.
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2170-2. Epub 2006 Feb 17.
- PubMed ID
- 16483771 [ View in PubMed]
- Abstract
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Galantamine Acetylcholinesterase IC 50 (nM) 590 N/A N/A Details