Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Article Details
- CitationCopy to clipboard
Tan Q, Blizzard TA, Morgan JD 2nd, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, Warrier S, Yudkovitz J, Wilkinson HA, Sharma N, Fitzgerald PM, Li S, Colwell L, Fisher JE, Adamski S, Reszka AA, Kimmel D, DiNinno F, Rohrer SP, Freedman LP, Schaeffer JM, Hammond ML
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorg Med Chem Lett. 2005 Mar 15;15(6):1675-81.
- PubMed ID
- 15745820 [ View in PubMed]
- Abstract
The discovery, synthesis, and SAR of chromanes as ER alpha subtype selective ligands are described. X-ray studies revealed that the origin of the ER alpha-selectivity resulted from a C-4 trans methyl substitution to the cis-2,3-diphenyl-chromane platform. Selected compounds from this class demonstrated very potent in vivo antagonism of estradiol in an immature rat uterine weight assay, effectively inhibited ovariectomy-induced bone resorption in a 42 days treatment paradigm, and lowered serum cholesterol levels in ovx'd adult rat models. The best antagonists 8F and 12F also exhibited potent inhibition of MCF-7 cell growth and were shown to be estrogen receptor down-regulators (SERDs).
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL Estrogen receptor alpha IC 50 (nM) 1.5 N/A N/A Details Compound 4-D Estrogen receptor alpha IC 50 (nM) 0.8 N/A N/A Details Estradiol Estrogen receptor alpha IC 50 (nM) 1.3 N/A N/A Details Estradiol Estrogen receptor beta IC 50 (nM) 1.1 N/A N/A Details