Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.

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Chen Z, Davies E, Miller WS, Shan S, Valenzano KJ, Kyle DJ

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5275-9.

PubMed ID

15454210 [ View in PubMed

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Abstract

Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Loperamide	Mu-type opioid receptor	Ki (nM)	0.53	N/A	N/A	Details