Substituted spiro [2.3'] oxindolespiro [3.2'']-5,6-dimethoxy-indane-1''-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.

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Ali MA, Ismail R, Choon TS, Yoon YK, Wei AC, Pandian S, Kumar RS, Osman H, Manogaran E

Substituted spiro [2.3'] oxindolespiro [3.2'']-5,6-dimethoxy-indane-1''-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):7064-6. doi: 10.1016/j.bmcl.2010.09.108. Epub 2010 Sep 26.

PubMed ID

20951037 [ View in PubMed

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Abstract

Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 mumol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Donepezil	Acetylcholinesterase	IC 50 (nM)	120	N/A	N/A	Details