Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
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Vizirianakis IS, Chatzopoulou M, Bonovolias ID, Nicolaou I, Demopoulos VJ, Tsiftsoglou AS
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
J Med Chem. 2010 Oct 14;53(19):6779-810. doi: 10.1021/jm100189a.
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- 20925433 [ View in PubMed]
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Tamibarotene Retinoic acid receptor alpha EC 50 (nM) 45 N/A N/A Details Tamibarotene Retinoic acid receptor beta EC 50 (nM) 235 N/A N/A Details