Drug interactions with new and investigational antiretrovirals.
Article Details
- CitationCopy to clipboard
Brown KC, Paul S, Kashuba AD
Drug interactions with new and investigational antiretrovirals.
Clin Pharmacokinet. 2009;48(4):211-41.
- PubMed ID
- 19492868 [ View in PubMed]
- Abstract
More than 20 individual and fixed-dose combinations of antiretrovirals are approved for the treatment of human immunodeficiency virus (HIV) infection. However, owing to the ongoing limitations of drug resistance and adverse effects, new treatment options are still required. A number of promising new agents in existing or new drug classes are in development or have recently been approved by the US FDA. Since these agents will be used in combination with other new and existing antiretrovirals, understanding the potential for drug interactions between these compounds is critical to their appropriate use. This article summarizes the drug interaction potential of new and investigational protease inhibitors (darunavir), non-nucleoside reverse transcriptase inhibitors (etravirine and rilpivirine), chemokine receptor antagonists (maraviroc, vicriviroc and INCB 9471), integrase inhibitors (raltegravir and elvitegravir) and maturation inhibitors (bevirimat).
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Darunavir Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAbemaciclibDarunavir The serum concentration of Abemaciclib can be increased when it is combined with Darunavir. AcalabrutinibDarunavir The serum concentration of Acalabrutinib can be increased when it is combined with Darunavir. AcenocoumarolDarunavir The serum concentration of Acenocoumarol can be increased when it is combined with Darunavir. AlectinibDarunavir The serum concentration of Alectinib can be increased when it is combined with Darunavir. AlpelisibDarunavir The serum concentration of Alpelisib can be increased when it is combined with Darunavir.