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Identification
NameDarunavir
Accession NumberDB01264  (EXPT00002)
TypeSmall Molecule
GroupsApproved
DescriptionDarunavir is a protease inhibitor used to treat HIV. It acts on the HIV aspartyl protease which the virus needs to cleave the HIV polyprotein into its functional fragments.
Structure
Thumb
Synonyms
(3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl N-((1S,2R)-1-benzyl-2-hydroxy-3-(N(1)-isobutylsulfanilamido)propyl)carbamate
(3R,3AS,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate
(3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
(3R,3AS,6ar)-tetrahydro-2H-furo[2,3-b]furan-3-yl (2S,3R)-4-(4-amino-N-neopentylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate
[(S)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-1-((R)-phenylmethyl)-propyl]-carbamic acid (3R,3as,6ar)-(hexahydro-furo[2,3-b]furan-3-yl) ester
{(1S,2R)-3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid (3R,3as,6ar)-(hexahydro-furo[2,3-b]furan-3-yl) ester
Darunavir
Darunavirum
N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide
TMC-114
TMC114
External Identifiers
  • AIDS073035
  • TMC114
  • UIC-94017
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pat-darunavirtablet400 mgoralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirtablet600 mgoralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirtablet150 mgoralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirtablet800 mgoralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Pat-darunavirtablet75 mgoralPatriot A Division Of Janssen IncNot applicableNot applicableCanada
Prezistatablet, film coated75 mg/1oralJanssen Products LP2009-01-14Not applicableUs
Prezistasuspension100 mgoralJanssen Inc2014-08-06Not applicableCanada
PrezistaFilm-coated tablet800 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet, film coated400 mg/1oralREMEDYREPACK INC.2013-05-09Not applicableUs
Prezistatablet800 mgoralJanssen Inc2012-11-09Not applicableCanada
Prezistatablet400 mgoralJanssen Inc2009-04-01Not applicableCanada
PrezistaFilm-coated tablet150 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet, film coated400 mg/1oralPhysicians Total Care, Inc.2008-12-09Not applicableUs
Prezistatablet, film coated150 mg/1oralJanssen Products LP2009-04-27Not applicableUs
PrezistaFilm-coated tablet300 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet300 mgoralJanssen Inc2006-08-092011-07-27Canada
Prezistatablet, film coated800 mg/1oralREMEDYREPACK INC.2013-05-29Not applicableUs
Prezistatablet600 mgoralJanssen Inc2009-03-17Not applicableCanada
PrezistaFilm-coated tablet75 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet, film coated600 mg/1oralPhysicians Total Care, Inc.2012-10-16Not applicableUs
PrezistaFilm-coated tablet600 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistasuspension100 mg/mLoralJanssen Products LP2011-12-16Not applicableUs
Prezistatablet, film coated400 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prezistatablet75 mgoralJanssen Inc2009-12-16Not applicableCanada
PrezistaOral Suspension100 mg/mlOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet, film coated600 mg/1oralJanssen Products LP2008-03-08Not applicableUs
Prezistatablet, film coated800 mg/1oralJanssen Products LP2012-11-09Not applicableUs
PrezistaFilm-coated tablet400 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Prezistatablet, film coated600 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prezistatablet150 mgoralJanssen Inc2012-04-16Not applicableCanada
PrezistaFilm-coated tablet800 mgOral useJanssen Cilag International Nv2007-02-12Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
PrezcobixJanssen Inc
Salts
Name/CASStructureProperties
Darunavir ethanolate
ThumbNot applicableDBSALT001338
Categories
UNIIYO603Y8113
CAS number206361-99-1
WeightAverage: 547.664
Monoisotopic: 547.235221243
Chemical FormulaC27H37N3O7S
InChI KeyInChIKey=CJBJHOAVZSMMDJ-HEXNFIEUSA-N
InChI
InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
IUPAC Name
(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)4-aminobenzenesulfonamido]-1-phenylbutan-2-yl]carbamate
SMILES
[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](CC1=CC=CC=C1)[[email protected]](O)CN(CC(C)C)S(=O)(=O)C1=CC=C(N)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentAminobenzenesulfonamides
Alternative Parents
Substituents
  • Phenylbutylamine
  • Aminobenzenesulfonamide
  • Sulfonylaniline
  • Amphetamine or derivatives
  • Substituted aniline
  • Furofuran
  • Aniline
  • Primary aromatic amine
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Oxolane
  • Secondary alcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Acetal
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationDarunavir, co-administered with ritonavir, and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency virus (HIV) infection in antiretroviral treatment-experienced adult patients, such as those with HIV-1 strains resistant to more than one protease inhibitor.
PharmacodynamicsDarunavir is an inhibitor of the human immunodeficiency virus (HIV) protease. In studies, the drug, co-administered with ritonavir in combination therapy, significantly reduced viral load and increased CD4 cell counts in this treatment-experienced patient population (Tibotec, 2006, Product Monograph, Prezista 2006). Darunavir is used as an adjunct therapy with low dose ritonavir, which inhibits cytochrome P450 3A (CYP3A) which increases the bioavailability and half life of darunavir.
Mechanism of actionDarunavir is a HIV protease inhibitor which prevents HIV replication by binding to the enzyme's active site, thereby preventing the dimerization and the catalytic activity of the HIV-1 protease. Darunavir selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virus particles. Structual analyses suggests that the close contact that darunavir has with the main chains of the protease active site amino acids (Asp-29 and Asp-30) is an important contributing factor to its potency and wide spectrum of activity against multi-protease inhibitor resistant HIV-1 variants. Darunavir can also adapt to the changing shape of a protease enzyme because of its molecular flexibility. Darunavir is known to bind to two distinct sites on the enzyme: the active site cavity and the surface of one of the flexible flaps in the protease dimer.
Related Articles
AbsorptionThe absolute oral bioavailability of a single 600 mg dose of darunavir alone and after co-administration with 100 mg ritonavir twice daily was 37% and 82%, respectively.
Volume of distributionNot Available
Protein bindingDarunavir is approximately 95% bound to plasma proteins. Darunavir binds primarily to plasma alpha 1-acid glycoprotein (AAG).
Metabolism

Hepatic. Darunavir is extensively metabolized by CYP enzymes, primarily by CYP3A.

Route of eliminationDarunavir is primarily metabolized by CYP3A. Darunavir is extensively metabolized by CYP enzymes, primarily by CYP3A. A mass balance study in healthy volunteers showed that after single dose administration of 400 mg 14C-darunavir, co-administered with 100 mg ritonavir, approximately 79.5% and 13.9% of the administered dose of 14C-darunavir was recovered in the feces and urine, respectively.
Half lifeThe terminal elimination half-life of darunavir was approximately 15 hours when combined with ritonavir.
Clearance
  • 32.8 L/hr [Healthy volunteers receiving intravenous administration of 400 mg of darunavir]
  • 5.9 L/hr [Healthy volunteers receiving intravenous administrations of 400 mg of darunavir and 100 mg of ritonavir twice daily]
ToxicityNot Available
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9636
Blood Brain Barrier-0.5518
Caco-2 permeable+0.7274
P-glycoprotein substrateSubstrate0.7464
P-glycoprotein inhibitor IInhibitor0.7588
P-glycoprotein inhibitor IINon-inhibitor0.8683
Renal organic cation transporterNon-inhibitor0.8847
CYP450 2C9 substrateNon-substrate0.5747
CYP450 2D6 substrateSubstrate0.6809
CYP450 3A4 substrateSubstrate0.6496
CYP450 1A2 substrateNon-inhibitor0.7328
CYP450 2C9 inhibitorNon-inhibitor0.6999
CYP450 2D6 inhibitorNon-inhibitor0.8784
CYP450 2C19 inhibitorNon-inhibitor0.6587
CYP450 3A4 inhibitorNon-inhibitor0.5076
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7132
Ames testNon AMES toxic0.5933
CarcinogenicityNon-carcinogens0.7991
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.5482 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9824
hERG inhibition (predictor II)Non-inhibitor0.857
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral
Tablet, film coatedoral
Film-coated tabletOral use150 mg
Film-coated tabletOral use300 mg
Film-coated tabletOral use400 mg
Film-coated tabletOral use600 mg
Film-coated tabletOral use75 mg
Film-coated tabletOral use800 mg
Oral suspensionOral use100 mg/ml
Suspensionoral100 mg
Suspensionoral100 mg/mL
Tabletoral150 mg
Tabletoral300 mg
Tabletoral400 mg
Tabletoral600 mg
Tabletoral75 mg
Tabletoral800 mg
Tablet, film coatedoral150 mg/1
Tablet, film coatedoral400 mg/1
Tablet, film coatedoral600 mg/1
Tablet, film coatedoral75 mg/1
Tablet, film coatedoral800 mg/1
Prices
Unit descriptionCostUnit
Prezista 600 mg tablet25.75USD tablet
Prezista 400 mg tablet18.74USD tablet
Prezista 300 mg tablet16.2USD tablet
Prezista 150 mg tablet4.59USD tablet
Prezista 75 mg tablet2.3USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2224738 No2002-08-272016-06-28Canada
CA2469343 No2008-05-132022-12-12Canada
US5843946 Yes1996-06-012016-06-01Us
US6037157 Yes1996-12-262016-12-26Us
US6335460 No1992-08-252012-08-25Us
US6703403 Yes1996-12-262016-12-26Us
US7470506 Yes1999-12-232019-12-23Us
US7700645 Yes2007-06-262027-06-26Us
US8148374 No2009-09-032029-09-03Us
US8518987 Yes2004-08-162024-08-16Us
US8597876 Yes1999-12-232019-12-23Us
USRE42889 Yes1997-04-192017-04-19Us
USRE43596 Yes1997-11-092017-11-09Us
USRE43802 Yes1997-04-192017-04-19Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityApproximately 0.15 mg/mL at 20 °C as ethanolate saltNot Available
logP1.8Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0668 mg/mLALOGPS
logP1.76ALOGPS
logP2.82ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)13.59ChemAxon
pKa (Strongest Basic)2.39ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area140.42 Å2ChemAxon
Rotatable Bond Count11ChemAxon
Refractivity142.34 m3·mol-1ChemAxon
Polarizability57.24 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US05158713
General References
  1. Back D, Sekar V, Hoetelmans RM: Darunavir: pharmacokinetics and drug interactions. Antivir Ther. 2008;13(1):1-13. [PubMed:18389894 ]
  2. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
  3. Koh Y, Matsumi S, Das D, Amano M, Davis DA, Li J, Leschenko S, Baldridge A, Shioda T, Yarchoan R, Ghosh AK, Mitsuya H: Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem. 2007 Sep 28;282(39):28709-20. Epub 2007 Jul 17. [PubMed:17635930 ]
  4. Kovalevsky AY, Tie Y, Liu F, Boross PI, Wang YF, Leshchenko S, Ghosh AK, Harrison RW, Weber IT: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem. 2006 Feb 23;49(4):1379-87. [PubMed:16480273 ]
  5. De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Bethune MP: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother. 2005 Jun;49(6):2314-21. [PubMed:15917527 ]
  6. Link [Link]
External Links
ATC CodesJ05AE10J05AR14
AHFS Codes
  • 08:18.08.08
PDB EntriesNot Available
FDA labelDownload (281 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Darunavir.
4-MethoxyamphetamineThe serum concentration of 4-Methoxyamphetamine can be increased when it is combined with Darunavir.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Darunavir.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Darunavir.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Darunavir.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Darunavir.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Darunavir.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Darunavir.
AcetylcholineThe serum concentration of Acetylcholine can be increased when it is combined with Darunavir.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Darunavir.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Darunavir.
AjmalineThe serum concentration of Ajmaline can be increased when it is combined with Darunavir.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Darunavir.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Darunavir.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Darunavir.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Darunavir.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Darunavir.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Darunavir.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Darunavir.
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Darunavir.
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Darunavir.
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Darunavir.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Darunavir.
AlprenololThe serum concentration of Alprenolol can be increased when it is combined with Darunavir.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Darunavir.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Darunavir.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Darunavir.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Darunavir.
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Darunavir.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Darunavir.
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Darunavir.
AmiodaroneThe metabolism of Darunavir can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Darunavir.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Darunavir.
AmoxapineThe serum concentration of Amoxapine can be increased when it is combined with Darunavir.
AmphetamineThe serum concentration of Amphetamine can be increased when it is combined with Darunavir.
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Darunavir.
AmsacrineThe serum concentration of Amsacrine can be increased when it is combined with Darunavir.
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Darunavir.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Darunavir.
ApremilastThe metabolism of Apremilast can be decreased when combined with Darunavir.
AprepitantThe serum concentration of Darunavir can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Darunavir.
AprindineThe serum concentration of Aprindine can be increased when it is combined with Darunavir.
ArformoterolThe serum concentration of Arformoterol can be increased when it is combined with Darunavir.
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Darunavir.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Darunavir.
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Darunavir.
AsenapineThe metabolism of Asenapine can be decreased when combined with Darunavir.
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Darunavir.
AtazanavirThe metabolism of Darunavir can be decreased when combined with Atazanavir.
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Darunavir.
AtomoxetineThe metabolism of Darunavir can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Darunavir.
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Darunavir.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Darunavir.
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Darunavir.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Darunavir.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Darunavir.
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Darunavir.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Darunavir.
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Darunavir.
BenzatropineThe serum concentration of Benzatropine can be increased when it is combined with Darunavir.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Darunavir.
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Darunavir.
BepridilThe serum concentration of Bepridil can be increased when it is combined with Darunavir.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Darunavir.
BetaxololThe serum concentration of Betaxolol can be increased when it is combined with Darunavir.
BexaroteneThe serum concentration of Darunavir can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Darunavir.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Darunavir.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Darunavir.
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Darunavir.
BoceprevirThe serum concentration of Darunavir can be decreased when it is combined with Boceprevir.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Darunavir.
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Darunavir.
BortezomibThe metabolism of Darunavir can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Darunavir can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Darunavir.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Darunavir.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Darunavir.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Darunavir.
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Darunavir.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Darunavir.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Darunavir.
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Darunavir.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Darunavir.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Darunavir.
BufuralolThe serum concentration of Bufuralol can be increased when it is combined with Darunavir.
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Darunavir.
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Darunavir.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Darunavir.
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Darunavir.
BusulfanThe metabolism of Busulfan can be decreased when combined with Darunavir.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Darunavir.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Darunavir.
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Darunavir.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Darunavir.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Darunavir.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Darunavir.
CaptoprilThe serum concentration of Captopril can be increased when it is combined with Darunavir.
CarbamazepineThe metabolism of Darunavir can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Darunavir.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Darunavir.
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Darunavir.
CarteololThe serum concentration of Carteolol can be increased when it is combined with Darunavir.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Darunavir.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Darunavir.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Darunavir.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Darunavir.
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Darunavir.
CeritinibThe serum concentration of Darunavir can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Darunavir.
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Darunavir.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Darunavir.
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Darunavir.
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Darunavir.
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Darunavir.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Darunavir.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Darunavir.
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Darunavir.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Darunavir.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Darunavir.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Darunavir.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Darunavir.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Darunavir.
CinnarizineThe serum concentration of Cinnarizine can be increased when it is combined with Darunavir.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Darunavir.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Darunavir.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Darunavir.
ClarithromycinThe metabolism of Darunavir can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Darunavir can be decreased when combined with Clemastine.
ClevidipineThe serum concentration of Clevidipine can be increased when it is combined with Darunavir.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Darunavir.
ClobazamThe metabolism of Clobazam can be decreased when combined with Darunavir.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Darunavir.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Darunavir.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Darunavir.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Darunavir.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Darunavir.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Darunavir.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Darunavir.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Darunavir.
ClopidogrelThe metabolism of Clopidogrel can be decreased when combined with Darunavir.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Darunavir.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Darunavir.
ClotrimazoleThe metabolism of Darunavir can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Darunavir.
CobicistatThe metabolism of Darunavir can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Darunavir.
CocaineThe metabolism of Cocaine can be decreased when combined with Darunavir.
CodeineThe serum concentration of Codeine can be increased when it is combined with Darunavir.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Darunavir.
ConivaptanThe serum concentration of Darunavir can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Darunavir.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Darunavir.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Darunavir.
CrizotinibThe metabolism of Darunavir can be decreased when combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Darunavir.
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Darunavir.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Darunavir.
CyclosporineThe metabolism of Darunavir can be decreased when combined with Cyclosporine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Darunavir.
DabrafenibThe serum concentration of Darunavir can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Darunavir.
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Darunavir.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Darunavir.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Darunavir.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Darunavir.
DapsoneThe metabolism of Dapsone can be decreased when combined with Darunavir.
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Darunavir.
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Darunavir can be increased when it is combined with Dasatinib.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Darunavir.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Darunavir.
DeferasiroxThe serum concentration of Darunavir can be decreased when it is combined with Deferasirox.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Darunavir.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Darunavir.
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Darunavir.
DelavirdineThe metabolism of Darunavir can be decreased when combined with Delavirdine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Darunavir.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Darunavir.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Darunavir.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Darunavir.
DexamethasoneThe serum concentration of Darunavir can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Darunavir.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Darunavir.
DexfenfluramineThe serum concentration of Dexfenfluramine can be increased when it is combined with Darunavir.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Darunavir.
DexmethylphenidateThe serum concentration of Dexmethylphenidate can be increased when it is combined with Darunavir.
DextroamphetamineThe serum concentration of Dextroamphetamine can be increased when it is combined with Darunavir.
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Darunavir.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Darunavir.
DiazepamThe metabolism of Diazepam can be decreased when combined with Darunavir.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Darunavir.
DidanosineThe serum concentration of Didanosine can be decreased when it is combined with Darunavir.
DienogestThe serum concentration of Dienogest can be increased when it is combined with Darunavir.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Darunavir.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Darunavir.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Darunavir.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Darunavir.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Darunavir.
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Darunavir.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Darunavir.
DihydroergotamineThe metabolism of Darunavir can be decreased when combined with Dihydroergotamine.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Darunavir.
DiltiazemThe metabolism of Darunavir can be decreased when combined with Diltiazem.
DiphenhydramineThe serum concentration of Diphenhydramine can be increased when it is combined with Darunavir.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Darunavir.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Darunavir.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Darunavir.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Darunavir.
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Darunavir.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Darunavir.
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Darunavir.
DopamineThe serum concentration of Dopamine can be increased when it is combined with Darunavir.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Darunavir.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Darunavir.
DoxazosinThe serum concentration of Doxazosin can be increased when it is combined with Darunavir.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Darunavir.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Darunavir.
DoxycyclineThe metabolism of Darunavir can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Darunavir.
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Darunavir.
DronedaroneThe metabolism of Darunavir can be decreased when combined with Dronedarone.
DrospirenoneThe serum concentration of Drospirenone can be increased when it is combined with Darunavir.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Darunavir.
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Darunavir.
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Darunavir.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Darunavir.
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Darunavir.
EfavirenzThe serum concentration of Darunavir can be decreased when it is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Darunavir.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Darunavir.
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Darunavir.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Darunavir.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Darunavir.
EncainideThe serum concentration of Encainide can be increased when it is combined with Darunavir.
EnclomipheneThe serum concentration of Enclomiphene can be increased when it is combined with Darunavir.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Darunavir.
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Darunavir.
EnzalutamideThe serum concentration of Darunavir can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Darunavir.
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Darunavir.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Darunavir.
EquilinThe serum concentration of Equilin can be increased when it is combined with Darunavir.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Darunavir.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Darunavir.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Darunavir.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Darunavir.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Darunavir.
ErythromycinThe metabolism of Darunavir can be decreased when combined with Erythromycin.
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Darunavir.
Eslicarbazepine acetateThe serum concentration of Darunavir can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Darunavir.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Darunavir.
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Darunavir.
EstradiolThe metabolism of Estradiol can be decreased when combined with Darunavir.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Darunavir.
EstramustineThe metabolism of Estramustine can be decreased when combined with Darunavir.
EstroneThe serum concentration of Estrone can be increased when it is combined with Darunavir.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Darunavir.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Darunavir.
EthanolThe metabolism of Ethanol can be decreased when combined with Darunavir.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Darunavir.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Darunavir.
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Darunavir.
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Darunavir.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Darunavir.
EtoposideThe metabolism of Etoposide can be decreased when combined with Darunavir.
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Darunavir.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Darunavir.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Darunavir.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Darunavir.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Darunavir.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Darunavir.
FelbamateThe metabolism of Felbamate can be decreased when combined with Darunavir.
FelodipineThe metabolism of Felodipine can be decreased when combined with Darunavir.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Darunavir.
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Darunavir.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Darunavir.
FinasterideThe metabolism of Finasteride can be decreased when combined with Darunavir.
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Darunavir.
FlecainideThe serum concentration of Flecainide can be increased when it is combined with Darunavir.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Darunavir.
FluconazoleThe metabolism of Darunavir can be decreased when combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Darunavir.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Darunavir.
FlunarizineThe serum concentration of Flunarizine can be increased when it is combined with Darunavir.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Darunavir.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Darunavir.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Darunavir.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Darunavir.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Darunavir.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Darunavir.
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Darunavir.
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Darunavir.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Darunavir.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Darunavir.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Darunavir.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Darunavir.
FlutamideThe metabolism of Flutamide can be decreased when combined with Darunavir.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Darunavir.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Darunavir.
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Darunavir.
FluvoxamineThe serum concentration of Fluvoxamine can be increased when it is combined with Darunavir.
FluvoxamineThe metabolism of Darunavir can be decreased when combined with Fluvoxamine.
FormoterolThe serum concentration of Formoterol can be increased when it is combined with Darunavir.
FosamprenavirThe metabolism of Darunavir can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Darunavir can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Darunavir can be decreased when it is combined with Fosphenytoin.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Darunavir.
Fusidic AcidThe serum concentration of Darunavir can be increased when it is combined with Fusidic Acid.
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Darunavir.
GarlicThe serum concentration of Darunavir can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Darunavir.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Darunavir.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Darunavir.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Darunavir.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Darunavir.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Darunavir.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Darunavir.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Darunavir.
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Darunavir.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Darunavir.
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Darunavir.
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Darunavir.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Darunavir.
HalothaneThe serum concentration of Halothane can be increased when it is combined with Darunavir.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Darunavir.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Darunavir.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Darunavir.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Darunavir.
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Darunavir.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Darunavir.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Darunavir.
IdarubicinThe serum concentration of Idarubicin can be increased when it is combined with Darunavir.
IdelalisibThe serum concentration of Darunavir can be increased when it is combined with Idelalisib.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Darunavir resulting in a loss in efficacy.
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Darunavir.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Darunavir.
ImatinibThe metabolism of Darunavir can be decreased when combined with Imatinib.
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Darunavir.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Darunavir.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Darunavir.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Darunavir.
IndapamideThe metabolism of Indapamide can be decreased when combined with Darunavir.
IndinavirThe metabolism of Darunavir can be decreased when combined with Indinavir.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Darunavir.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Darunavir.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Darunavir.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Darunavir.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Darunavir.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Darunavir.
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Darunavir.
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Darunavir.
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Darunavir.
IsavuconazoniumThe metabolism of Darunavir can be decreased when combined with Isavuconazonium.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Darunavir.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Darunavir.
IsradipineThe metabolism of Darunavir can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Darunavir.
ItraconazoleThe metabolism of Darunavir can be decreased when combined with Itraconazole.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Darunavir.
IvacaftorThe serum concentration of Darunavir can be increased when it is combined with Ivacaftor.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Darunavir.
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Darunavir.
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Darunavir.
KetamineThe metabolism of Ketamine can be decreased when combined with Darunavir.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Darunavir.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Darunavir.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Darunavir.
KetoconazoleThe metabolism of Darunavir can be decreased when combined with Ketoconazole.
LabetalolThe serum concentration of Labetalol can be increased when it is combined with Darunavir.
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Darunavir.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Darunavir.
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Darunavir.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Darunavir.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Darunavir.
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Darunavir.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Darunavir.
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Darunavir.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Darunavir.
LevodopaThe serum concentration of Levodopa can be increased when it is combined with Darunavir.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Darunavir.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Darunavir.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Darunavir.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Darunavir.
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Darunavir.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Darunavir.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Darunavir.
LisurideThe serum concentration of Lisuride can be increased when it is combined with Darunavir.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Darunavir.
LomustineThe serum concentration of Lomustine can be increased when it is combined with Darunavir.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Darunavir.
LopinavirThe serum concentration of Darunavir can be decreased when it is combined with Lopinavir.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Darunavir.
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Darunavir.
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Darunavir.
LosartanThe metabolism of Losartan can be decreased when combined with Darunavir.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Darunavir.
LovastatinThe metabolism of Darunavir can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Darunavir can be increased when it is combined with Luliconazole.
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Darunavir.
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Darunavir.
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Darunavir.
MaprotilineThe serum concentration of Maprotiline can be increased when it is combined with Darunavir.
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Darunavir.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Darunavir.
MecamylamineThe risk or severity of adverse effects can be increased when Darunavir is combined with Mecamylamine.
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Darunavir.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Darunavir.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Darunavir.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Darunavir.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Darunavir.
MephenytoinThe serum concentration of Mephenytoin can be increased when it is combined with Darunavir.
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Darunavir.
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Darunavir.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Darunavir.
MethadoneThe serum concentration of Methadone can be increased when it is combined with Darunavir.
MethamphetamineThe serum concentration of Methamphetamine can be increased when it is combined with Darunavir.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Darunavir.
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Darunavir.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Darunavir.
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Darunavir.
MethylphenidateThe serum concentration of Methylphenidate can be increased when it is combined with Darunavir.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Darunavir.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Darunavir.
MethyprylonThe serum concentration of Methyprylon can be increased when it is combined with Darunavir.
MetoclopramideThe serum concentration of Metoclopramide can be increased when it is combined with Darunavir.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Darunavir.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Darunavir.
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Darunavir.
MianserinThe serum concentration of Mianserin can be increased when it is combined with Darunavir.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Darunavir.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Darunavir.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Darunavir.
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Darunavir.
MifepristoneThe metabolism of Darunavir can be decreased when combined with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Darunavir.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Darunavir.
MinaprineThe serum concentration of Minaprine can be increased when it is combined with Darunavir.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Darunavir.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Darunavir.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Darunavir.
MitotaneThe serum concentration of Darunavir can be decreased when it is combined with Mitotane.
MoclobemideThe serum concentration of Moclobemide can be increased when it is combined with Darunavir.
ModafinilThe serum concentration of Darunavir can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Darunavir.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Darunavir.
MontelukastThe metabolism of Montelukast can be decreased when combined with Darunavir.
MorphineThe serum concentration of Morphine can be increased when it is combined with Darunavir.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Darunavir.
NafcillinThe serum concentration of Darunavir can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Darunavir.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Darunavir.
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Darunavir.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Darunavir.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Darunavir.
NefazodoneThe metabolism of Darunavir can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Darunavir can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Darunavir can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Darunavir.
NevirapineThe metabolism of Darunavir can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Darunavir.
NicergolineThe serum concentration of Nicergoline can be increased when it is combined with Darunavir.
NicotineThe serum concentration of Nicotine can be increased when it is combined with Darunavir.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Darunavir.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Darunavir.
NilotinibThe metabolism of Darunavir can be decreased when combined with Nilotinib.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Darunavir.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Darunavir.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Darunavir.
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Darunavir.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Darunavir.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Darunavir.
NitrofuralThe serum concentration of Nitrofural can be increased when it is combined with Darunavir.
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Darunavir.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Darunavir.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Darunavir.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Darunavir.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Darunavir.
OlaparibThe metabolism of Darunavir can be decreased when combined with Olaparib.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Darunavir.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Darunavir.
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Darunavir.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Darunavir.
OsimertinibThe serum concentration of Darunavir can be increased when it is combined with Osimertinib.
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Darunavir.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Darunavir.
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Darunavir.
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Darunavir.
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Darunavir.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Darunavir.
PalbociclibThe serum concentration of Darunavir can be increased when it is combined with Palbociclib.
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Darunavir.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Darunavir.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Darunavir.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Darunavir.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Darunavir.
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Darunavir.
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Darunavir.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Darunavir.
ParoxetineThe serum concentration of Paroxetine can be increased when it is combined with Darunavir.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Darunavir.
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Darunavir.
PentobarbitalThe metabolism of Darunavir can be increased when combined with Pentobarbital.
PerampanelThe metabolism of Perampanel can be decreased when combined with Darunavir.
PergolideThe metabolism of Pergolide can be decreased when combined with Darunavir.
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Darunavir.
PermethrinThe metabolism of Permethrin can be decreased when combined with Darunavir.
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Darunavir.
PethidineThe serum concentration of Pethidine can be increased when it is combined with Darunavir.
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Darunavir.
PhenforminThe serum concentration of Phenformin can be increased when it is combined with Darunavir.
PhenobarbitalThe serum concentration of Phenobarbital can be decreased when it is combined with Darunavir.
PhenobarbitalThe metabolism of Darunavir can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Darunavir.
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Darunavir.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Darunavir.
PhenytoinThe metabolism of Darunavir can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Darunavir.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Darunavir.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Darunavir.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Darunavir.
PindololThe serum concentration of Pindolol can be increased when it is combined with Darunavir.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Darunavir.
PiperazineThe serum concentration of Piperazine can be increased when it is combined with Darunavir.
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Darunavir.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Darunavir.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Darunavir.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Darunavir.
PosaconazoleThe metabolism of Darunavir can be decreased when combined with Posaconazole.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Darunavir.
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Darunavir.
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Darunavir resulting in a loss in efficacy.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Darunavir.
PrazepamThe metabolism of Prazepam can be decreased when combined with Darunavir.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Darunavir.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Darunavir.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Darunavir.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Darunavir.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Darunavir.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Darunavir.
PrimidoneThe metabolism of Darunavir can be increased when combined with Primidone.
ProcainamideThe serum concentration of Procainamide can be increased when it is combined with Darunavir.
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Darunavir.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Darunavir.
ProguanilThe metabolism of Proguanil can be decreased when combined with Darunavir.
PromazineThe metabolism of Promazine can be decreased when combined with Darunavir.
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Darunavir.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Darunavir.
PropofolThe serum concentration of Propofol can be increased when it is combined with Darunavir.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Darunavir.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Darunavir.
PseudoephedrineThe serum concentration of Pseudoephedrine can be increased when it is combined with Darunavir.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Darunavir.
QuazepamThe metabolism of Quazepam can be decreased when combined with Darunavir.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Darunavir.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Darunavir.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Darunavir.
QuinineThe serum concentration of Quinine can be increased when it is combined with Darunavir.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Darunavir.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Darunavir.
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Darunavir.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Darunavir.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Darunavir.
RanolazineThe metabolism of Darunavir can be decreased when combined with Ranolazine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Darunavir.
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Darunavir.
RemoxiprideThe serum concentration of Remoxipride can be increased when it is combined with Darunavir.
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Darunavir.
repinotanThe serum concentration of repinotan can be increased when it is combined with Darunavir.
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Darunavir.
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Darunavir.
RifabutinThe metabolism of Darunavir can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Darunavir can be decreased when it is combined with Rifampicin.
RifampicinThe metabolism of Rifampicin can be decreased when combined with Darunavir.
RifapentineThe serum concentration of Darunavir can be decreased when it is combined with Rifapentine.
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Darunavir.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Darunavir.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Darunavir.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Darunavir.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Darunavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Darunavir.
RitonavirThe metabolism of Darunavir can be decreased when combined with Ritonavir.
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Darunavir.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Darunavir.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Darunavir.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Darunavir.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Darunavir.
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Darunavir.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Darunavir.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Darunavir.
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Darunavir.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Darunavir.
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Darunavir.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Darunavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Darunavir.
SaquinavirThe serum concentration of Darunavir can be decreased when it is combined with Saquinavir.
SaxagliptinThe therapeutic efficacy of Saxagliptin can be decreased when used in combination with Darunavir.
SelegilineThe metabolism of Selegiline can be decreased when combined with Darunavir.
SelexipagThe metabolism of Selexipag can be decreased when combined with Darunavir.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Darunavir.
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Darunavir.
SertralineThe serum concentration of Sertraline can be increased when it is combined with Darunavir.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Darunavir.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Darunavir.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Darunavir.
SildenafilThe metabolism of Darunavir can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Darunavir.
SiltuximabThe serum concentration of Darunavir can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Darunavir can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Darunavir.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Darunavir.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Darunavir.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Darunavir.
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Darunavir.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Darunavir.
SparteineThe serum concentration of Sparteine can be increased when it is combined with Darunavir.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Darunavir.
St. John's WortThe metabolism of Darunavir can be increased when combined with St. John's Wort.
StiripentolThe serum concentration of Darunavir can be increased when it is combined with Stiripentol.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Darunavir.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Darunavir.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Darunavir.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Darunavir.
SulfisoxazoleThe metabolism of Darunavir can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Darunavir.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Darunavir.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Darunavir.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Darunavir.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Darunavir.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Darunavir.
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Darunavir.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Darunavir.
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Darunavir.
TapentadolThe serum concentration of Tapentadol can be increased when it is combined with Darunavir.
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Darunavir.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Darunavir.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Darunavir.
TegaserodThe serum concentration of Tegaserod can be increased when it is combined with Darunavir.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Darunavir.
TelaprevirThe metabolism of Darunavir can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Darunavir can be decreased when combined with Telithromycin.
TemazepamThe metabolism of Temazepam can be decreased when combined with Darunavir.
TemsirolimusThe risk or severity of adverse effects can be increased when Darunavir is combined with Temsirolimus.
TeniposideThe metabolism of Teniposide can be decreased when combined with Darunavir.
TenofovirThe serum concentration of Darunavir can be increased when it is combined with Tenofovir.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Darunavir.
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Darunavir.
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Darunavir.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Darunavir.
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Darunavir.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Darunavir.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Darunavir.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Darunavir.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Darunavir.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Darunavir.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Darunavir.
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Darunavir resulting in a loss in efficacy.
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Darunavir.
TiclopidineThe metabolism of Darunavir can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Darunavir.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Darunavir.
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Darunavir.
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Darunavir.
TipranavirThe serum concentration of Darunavir can be decreased when it is combined with Tipranavir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Darunavir.
TocilizumabThe serum concentration of Darunavir can be decreased when it is combined with Tocilizumab.
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Darunavir.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Darunavir.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Darunavir.
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Darunavir.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Darunavir.
ToremifeneThe risk or severity of adverse effects can be increased when Darunavir is combined with Toremifene.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Darunavir.
TramadolThe serum concentration of Tramadol can be increased when it is combined with Darunavir.
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Darunavir.
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Darunavir.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Darunavir.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Darunavir.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Darunavir.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Darunavir.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Darunavir.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Darunavir.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Darunavir.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Darunavir.
UdenafilThe metabolism of Udenafil can be decreased when combined with Darunavir.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Darunavir.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Darunavir.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Darunavir.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Darunavir.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Darunavir.
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Darunavir.
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Darunavir.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Darunavir.
VenlafaxineThe metabolism of Darunavir can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Darunavir can be decreased when combined with Verapamil.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Darunavir.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Darunavir.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Darunavir.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Darunavir.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Darunavir.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Darunavir.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Darunavir.
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Darunavir.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Darunavir.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Darunavir.
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Darunavir.
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Darunavir.
VoriconazoleThe metabolism of Darunavir can be decreased when combined with Voriconazole.
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Darunavir.
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Darunavir.
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Darunavir.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Darunavir.
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Darunavir.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Darunavir.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Darunavir.
ZileutonThe metabolism of Zileuton can be decreased when combined with Darunavir.
ZiprasidoneThe metabolism of Darunavir can be decreased when combined with Ziprasidone.
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Darunavir.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Darunavir.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Darunavir.
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Darunavir.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Darunavir.
Food Interactions
  • Take with food - better absorption (+30%).

Targets

Kind
Protein
Organism
Human immunodeficiency virus 1
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
pol
Uniprot ID:
Q72874
Molecular Weight:
10778.7 Da
References
  1. Dierynck I, De Wit M, Gustin E, Keuleers I, Vandersmissen J, Hallenberger S, Hertogs K: Binding kinetics of darunavir to human immunodeficiency virus type 1 protease explain the potent antiviral activity and high genetic barrier. J Virol. 2007 Dec;81(24):13845-51. Epub 2007 Oct 10. [PubMed:17928344 ]
  2. Ghosh AK, Dawson ZL, Mitsuya H: Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV. Bioorg Med Chem. 2007 Dec 15;15(24):7576-80. Epub 2007 Sep 14. [PubMed:17900913 ]
  3. Wang YF, Tie Y, Boross PI, Tozser J, Ghosh AK, Harrison RW, Weber IT: Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J Med Chem. 2007 Sep 6;50(18):4509-15. Epub 2007 Aug 16. [PubMed:17696515 ]
  4. McKeage K, Perry CM, Keam SJ: Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007. [PubMed:19323590 ]
  5. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
  6. Kovalevsky AY, Tie Y, Liu F, Boross PI, Wang YF, Leshchenko S, Ghosh AK, Harrison RW, Weber IT: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. J Med Chem. 2006 Feb 23;49(4):1379-87. [PubMed:16480273 ]
  7. De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wigerinck P, de Bethune MP: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother. 2005 Jun;49(6):2314-21. [PubMed:15917527 ]
  8. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. McKeage K, Perry CM, Keam SJ: Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. doi: 10.2165/00003495-200969040-00007. [PubMed:19323590 ]
  2. Tremblay CL: Combating HIV resistance - focus on darunavir. Ther Clin Risk Manag. 2008 Aug;4(4):759-66. [PubMed:19209258 ]
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Drug created on May 16, 2007 11:43 / Updated on September 25, 2016 03:31