Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine.
Article Details
- CitationCopy to clipboard
Yoshimura R, Ueda N, Nakamura J
Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine.
Int Clin Psychopharmacol. 2000 Jul;15(4):233-5.
- PubMed ID
- 10954064 [ View in PubMed]
- Abstract
The cytochrome enzyme P450 2D6 (CYP2D6) is thought to play a role in the human metabolism of fluvoxamine. Levomepromazine is a potent inhibitor of CYP2D6. We coadministered a low dosage of levomepromazine and fluvoxamine in 15 patients and found that the low dosage of levomepromazine was effective in counteracting the fluvoxamine-induced insomnia and did not increase plasma fluvoxamine levels. These results suggest that the inhibition of CYP2D6 by levomepromazine has little effect on fluvoxamine metabolism. Therefore, a low dosage of levomepromazine, used as a hypnotic agent, appears to be effective and safe when coadministered with fluvoxamine. Since this was a pilot study without a placebo control, a double-blind placebo-controlled study is needed to confirm our preliminary findings.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Methotrimeprazine Cytochrome P450 2D6 Protein Humans UnknownSubstrateInhibitorDetails