Isoniazid metabolism and hepatotoxicity.

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Wang P, Pradhan K, Zhong XB, Ma X

Isoniazid metabolism and hepatotoxicity.

Acta Pharm Sin B. 2016 Sep;6(5):384-392. doi: 10.1016/j.apsb.2016.07.014. Epub 2016 Aug 3.

PubMed ID

27709007 [ View in PubMed

]

Abstract

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Isoniazid	Cytochrome P450 2E1	Protein	Humans	Unknown	Substrate Inhibitor Inducer	Details

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Isoniazid Disulfiram	The risk or severity of adverse effects can be increased when Disulfiram is combined with Isoniazid.