O-Methylation, the principal route of metabolism of epinephrine in man.
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LABROSSE EH, AXELROD J, KETY SS
O-Methylation, the principal route of metabolism of epinephrine in man.
Science. 1958 Sep 12;128(3324):593-4.
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- 13580222 [ View in PubMed]
- Abstract
Evidence is presented which indicates that the principal pathway of metabolism of epinephrine in man is O-methylation to metanephrine. The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.
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