[Theoretical basis for low-dose CDDP/5-FU therapy].

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Kubota T

[Theoretical basis for low-dose CDDP/5-FU therapy].

Gan To Kagaku Ryoho. 1999 Oct;26(11):1536-41.

PubMed ID

10553409 [ View in PubMed

]

Abstract

The theoretical basis for low-dose cisplatin (CDDP)/5-fluorouracil (5-FU) therapy is rather clear. CDDP can inhibit methionine-uptake into tumor cells and cause depletion of folate cofactors including 5-CH3FH4 and FH4, which are essential for the formation of a ternary complex with thymidylate synthetase and 5-fluorodeoxyuridine, an active metabolite of 5-FU. The literature on this mechanism are reviewed herein, and the methionine-dependency of human cancer xenografts and the modulation of 5-FU-cytotoxicity through methionine-depletion are reported.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Floxuridine	Thymidylate synthase	Protein	Humans	Yes	Not Available	Details