Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy.

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Vadivelu S, Sharer L, Schulder M

Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy.

J Neurosurg. 2010 May;112(5):920-4. doi: 10.3171/2009.8.JNS09201.

PubMed ID

19731987 [ View in PubMed

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Abstract

The authors present the case of a patient that demonstrates the long-standing use of megestrol acetate, a progesterone agonist, and its association with multiple intracranial meningioma presentation. Discontinuation of megestrol acetate led to shrinkage of multiple tumors and to the complete resolution of one tumor. Histological examination demonstrated that the largest tumor had high (by > 25% of tumor cell nuclei) progesterone-positive expression, including progesterone receptor (PR) isoform B, compared with low expression of PR isoform A; there was no evidence of estrogen receptor expression and only unaccentuated collagen expression. This is the first clinical report illustrating a causal relationship between exogenous hormones and modulation of meningioma biology in situ.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Megestrol acetate	Progesterone receptor	Protein	Humans	Yes	Agonist	Details