Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Article Details
- CitationCopy to clipboard
Wang H, Tang XC
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):27-30.
- PubMed ID
- 10375753 [ View in PubMed]
- Abstract
AIM: To compare the anticholinesterase effects of huperzine A (Hup A), E2020, and tacrine in rats. METHODS: Spectrophotometry was used to determine AChE activity in brain and BuChE activity in serum. RESULTS: Following intragastric gavage, Hup A, E2020, and tacrine all produced dose-dependent inhibitions of brain AChE. Oral Hup A exhibited a higher inhibition than E2020 and tacrine. Tacrine was more effective in inhibiting serum BuChE correlated with severe peripheral adverse effects. The BuChE activity was less affected by Hup A and E2020. After a single oral dose of Hup A, a relatively steady state of AChE inhibition produced, which was longer than that after E2020 and tacrine. No change in the cholinesterase inhibition was seen for the 3 drugs following repeated i.g. medications. CONCLUSION: Hup A i.g. exhibited a higher efficacy, a longer duration of action, and a more selective inhibition on AChE than E2020 and tacrine.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tacrine Acetylcholinesterase Protein Humans YesInhibitorDetails Tacrine Cholinesterase Protein Humans YesInhibitorDetails