Histopathology and evaluation of potentiation of morphine-induced antinociception by intrathecal droperidol in the rat.

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Grip G, Svensson BA, Gordh T Jr, Post C, Hartvig P

Histopathology and evaluation of potentiation of morphine-induced antinociception by intrathecal droperidol in the rat.

Acta Anaesthesiol Scand. 1992 Feb;36(2):145-52.

PubMed ID

1549935 [ View in PubMed

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Abstract

Clinical studies have indicated that a low dose of the dopamine D2-receptor antagonist droperidol given epidurally potentiate the antinociceptive effect of epidural morphine. The present study was conducted in order to evaluate this drug interaction in a rat model. Rats were given morphine and droperidol intrathecally in several combinations of doses. It was found that droperidol had no antinociceptive effect by itself, nor in combination with morphine. It was also shown that droperidol and morphine exert no histopathological effects on the rat spinal cord. This discrepancy between clinical findings and experimental pain studies suggests different modes of action of droperidol in the two situations.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Droperidol	Dopamine D2 receptor	Protein	Humans	Yes	Antagonist	Details