Fibroblast growth factor signalling: from development to cancer.
Article Details
- CitationCopy to clipboard
Turner N, Grose R
Fibroblast growth factor signalling: from development to cancer.
Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780.
- PubMed ID
- 20094046 [ View in PubMed]
- Abstract
Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. Although targeting FGF signalling as a cancer therapeutic target has lagged behind that of other receptor tyrosine kinases, there is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed. Although FGF signalling can drive tumorigenesis, in different contexts FGF signalling can mediate tumour protective functions; the identification of the mechanisms that underlie these differential effects will be important to understand how FGF signalling can be most appropriately therapeutically targeted.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Fibroblast growth factor 4 P08620 Details Fibroblast growth factor 1 P05230 Details Fibroblast growth factor receptor 2 P21802 Details Fibroblast growth factor 2 P09038 Details Fibroblast growth factor receptor 4 P22455 Details Fibroblast growth factor receptor 1 P11362 Details Fibroblast growth factor receptor 3 P22607 Details Fibroblast growth factor 19 O95750 Details