Repeated administration of opioids alters characteristics of membrane-bound phorbol ester binding in rat brain.
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Narita M, Feng Y, Makimura M, Hoskins B, Ho IK
Repeated administration of opioids alters characteristics of membrane-bound phorbol ester binding in rat brain.
Eur J Pharmacol. 1994 Dec 27;271(2-3):547-50.
- PubMed ID
- 7705457 [ View in PubMed]
- Abstract
Scatchard analysis of saturation binding data indicated that dissociation constant (KD) of [3H]phorbol 12,13-dibutyrate (PDB) binding to the membrane-bound protein kinase C of rat cortex and midbrain was significantly decreased following systemic repeated administration of morphine (mu-opioid receptor agonist) and butorphanol (mu/delta/kappa-mixed opioid receptor agonist). No change in the receptor density (Bmax) of [3H]PDB binding was found following repeated treatment with morphine and butorphanol. On the other hand, neither the Bmax nor KD values in pons/medulla were altered in these rats. These results suggest that systemic repeated opioid treatment, such as morphine and butorphanol leads to an increased affinity for phorbol ester binding to the membrane-bound protein kinase C in rat cortex and midbrain.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Butorphanol Delta-type opioid receptor Protein Humans YesAgonistDetails Butorphanol Kappa-type opioid receptor Protein Humans YesAgonistDetails Butorphanol Mu-type opioid receptor Protein Humans YesAntagonistDetails