Comparison of the pharmacology of nafarelin and danazol.

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Barbieri RL

Comparison of the pharmacology of nafarelin and danazol.

Am J Obstet Gynecol. 1990 Feb;162(2):581-5.

PubMed ID

2137975 [ View in PubMed

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Abstract

The pharmacologic profiles of danazol and nafarelin differ considerably from each other. Danazol interacts with multiple classes of proteins, whereas the gonadotropin-releasing hormone agonist nafarelin interacts only with the pituitary gonadotropin-releasing hormone receptor. Differences in the molecular, endocrine, and clinical pharmacologic properties of these agents may provide clues to their varying effects in the management of women with endometriosis.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nafarelin	Gonadotropin-releasing hormone receptor	Protein	Humans	Yes	Agonist	Details
Nafarelin	Putative gonadotropin-releasing hormone II receptor	Protein	Humans	Yes	Agonist	Details