Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.

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Guillou C, Mary A, Renko DZ, Gras E, Thal C

Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.

Bioorg Med Chem Lett. 2000 Apr 3;10(7):637-9.

PubMed ID

10762042 [ View in PubMed

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Abstract

The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Galantamine	Acetylcholinesterase	Protein	Humans	Yes	Inhibitor	Details