Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose.

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Hoffman DJ, Chun AH

Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose.

J Pharm Sci. 1975 Oct;64(10):1702-3.

PubMed ID
1185541 [ View in PubMed
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Abstract

A GLC method was developed to determine quantitatively paramethadione and its major metabolite, 5-ethyl-5-methyl-2,4-oxazolidinedione, in serum. The method was reproducible and sensitive to 0.2 mug/ml. After administering a single 300-mg oral dose to human subjects, the average paramethadione serum levels of 6.0 mug/ml occurred at 1 hr and decreased to 0.3 mug/ml after 48 hr. Metabolite serum levels gradually increased to 8.4 mug/ml at 32 hr and were still at this level at 48 hr, which was the last sampling point.

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