POU domain, class 5, transcription factor 1
Details
- Name
- POU domain, class 5, transcription factor 1
- Synonyms
- Oct-3
- Oct-4
- OCT3
- OCT4
- Octamer-binding protein 3
- Octamer-binding protein 4
- Octamer-binding transcription factor 3
- OTF-3
- OTF3
- Gene Name
- POU5F1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007044|POU domain, class 5, transcription factor 1 MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN
- Number of residues
- 360
- Molecular Weight
- 38570.415
- Theoretical pI
- 5.75
- GO Classification
- FunctionsDNA binding / miRNA binding / poly(A) RNA binding / RNA polymerase II transcription factor activity, sequence-specific DNA binding / sequence-specific DNA binding / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding / transcription regulatory region sequence-specific DNA binding / transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding / ubiquitin protein ligase bindingProcessesanatomical structure morphogenesis / blastocyst development / BMP signaling pathway involved in heart induction / cardiac cell fate determination / cell fate commitment involved in formation of primary germ layer / endodermal cell fate specification / mRNA transcription from RNA polymerase II promoter / negative regulation of gene silencing by miRNA / negative regulation of transcription from RNA polymerase II promoter / positive regulation of catenin import into nucleus / positive regulation of SMAD protein import into nucleus / positive regulation of transcription from RNA polymerase II promoter / regulation of asymmetric cell division / regulation of gene expression / regulation of heart induction by regulation of canonical Wnt signaling pathway / regulation of methylation-dependent chromatin silencing / regulation of transcription, DNA-templated / response to wounding / somatic stem cell population maintenance / transcription from RNA polymerase II promoterComponentscytoplasm / cytosol / nucleoplasm / nucleus / transcription factor complex
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0007043|1083 bp ATGGCGGGACACCTGGCTTCGGATTTCGCCTTCTCGCCCCCTCCAGGTGGTGGAGGTGAT GGGCCAGGGGGGCCGGAGCCGGGCTGGGTTGATCCTCGGACCTGGCTAAGCTTCCAAGGC CCTCCTGGAGGGCCAGGAATCGGGCCGGGGGTTGGGCCAGGCTCTGAGGTGTGGGGGATT CCCCCATGCCCCCCGCCGTATGAGTTCTGTGGGGGGATGGCGTACTGTGGGCCCCAGGTT GGAGTGGGGCTAGTGCCCCAAGGCGGCTTGGAGACCTCTCAGCCTGAGGGCGAAGCAGGA GTCGGGGTGGAGAGCAACTCCGATGGGGCCTCCCCGGAGCCCTGCACCGTCACCCCTGGT GCCGTGAAGCTGGAGAAGGAGAAGCTGGAGCAAAACCCGGAGGAGTCCCAGGACATCAAA GCTCTGCAGAAAGAACTCGAGCAATTTGCCAAGCTCCTGAAGCAGAAGAGGATCACCCTG GGATATACACAGGCCGATGTGGGGCTCACCCTGGGGGTTCTATTTGGGAAGGTATTCAGC CAAACGACCATCTGCCGCTTTGAGGCTCTGCAGCTTAGCTTCAAGAACATGTGTAAGCTG CGGCCCTTGCTGCAGAAGTGGGTGGAGGAAGCTGACAACAATGAAAATCTTCAGGAGATA TGCAAAGCAGAAACCCTCGTGCAGGCCCGAAAGAGAAAGCGAACCAGTATCGAGAACCGA GTGAGAGGCAACCTGGAGAATTTGTTCCTGCAGTGCCCGAAACCCACACTGCAGCAGATC AGCCACATCGCCCAGCAGCTTGGGCTCGAGAAGGATGTGGTCCGAGTGTGGTTCTGTAAC CGGCGCCAGAAGGGCAAGCGATCAAGCAGCGACTATGCACAACGAGAGGATTTTGAGGCT GCTGGGTCTCCTTTCTCAGGGGGACCAGTGTCCTTTCCTCTGGCCCCAGGGCCCCATTTT GGTACCCCAGGCTATGGGAGCCCTCACTTCACTGCACTGTACTCCTCGGTCCCTTTCCCT GAGGGGGAAGCCTTTCCCCCTGTCTCTGTCACCACTCTGGGCTCTCCCATGCATTCAAAC TGA
- Chromosome Location
- Not Available
- Locus
- 6p21.31
- External Identifiers
Resource Link UniProtKB ID Q01860 UniProtKB Entry Name PO5F1_HUMAN GenBank Protein ID 35169 GenBank Gene ID Z11898 HGNC ID HGNC:9221 - General References
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