Sulbactam pivoxil
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Sulbactam pivoxil is a prodrug of a beta-lactamase inhibitor used to improve the efficacy of beta lactam antibiotics
- Generic Name
- Sulbactam pivoxil
- DrugBank Accession Number
- DB15761
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 347.38
Monoisotopic: 347.103873194 - Chemical Formula
- C14H21NO7S
- Synonyms
- Pivsulbactam
- Sulbactam pivoxil
- Sulbactam pivoxyl
- External IDs
- CP 47904
- CP-47,904
- CP-47904
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Bacterial infections Combination Product in combination with: Amoxicillin (DB01060) •••••••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image EUMOXIN DUO FORTE Sulbactam pivoxil (5 g) + Amoxicillin Trihydrate (20 g) Powder, for suspension Oral SERVICIO TECNICO GONHER FARMACEUTICA LTDA. 2008-10-15 Not applicable Colombia EUMOXIN® DUO FORTE Sulbactam pivoxil (125 mg) + Amoxicillin (875 mg) Tablet, coated Oral SERVICIO TECNICO GONHER FARMACEUTICA LTDA. 2008-06-20 Not applicable Colombia TRIFAMOX IBL DUO® COMPRIMIDOS Sulbactam pivoxil (125 mg) + Amoxicillin Trihydrate (875 mg) Tablet, film coated Oral SYNTOPHARMA S.A. PLANTA PENICILINAS 2006-11-10 2021-04-01 Colombia
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2X0WTA96KX
- CAS number
- 69388-79-0
- InChI Key
- OHPVYKXTRACOSQ-ZJUUUORDSA-N
- InChI
- InChI=1S/C14H21NO7S/c1-13(2,3)12(18)22-7-21-11(17)10-14(4,5)23(19,20)9-6-8(16)15(9)10/h9-10H,6-7H2,1-5H3/t9-,10+/m1/s1
- IUPAC Name
- [(2S,5R)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carbonyloxy]methyl 2,2-dimethylpropanoate
- SMILES
- [H][C@@]12CC(=O)N1[C@@H](C(=O)OCOC(=O)C(C)(C)C)C(C)(C)S2(=O)=O
References
- General References
- Trifamox IBL Duo Product Information [Link]
- External Links
- ChemSpider
- 8173402
- 166010
- ChEBI
- 135467
- ChEMBL
- CHEMBL423875
- ZINC
- ZINC000004217478
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet, coated Oral Tablet, film coated Oral Powder, for suspension Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.3 mg/mL ALOGPS logP 0.64 ALOGPS logP 0.92 Chemaxon logS -2.2 ALOGPS pKa (Strongest Acidic) 18.59 Chemaxon pKa (Strongest Basic) -3.8 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 107.05 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 76.94 m3·mol-1 Chemaxon Polarizability 33.95 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0019000000-7c4b7a3290efe4974657 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03dj-0194000000-94ddb5075a3d81e915fa Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0aos-9162000000-f878643e8b80c093a1d8 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-03yl-7891000000-cb6dc5327412cf20d879 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-9210000000-fc26e2eee12c3ec75e3f Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-03fu-9210000000-0d1d4a84badd5819089f Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at August 18, 2020 15:20 / Updated at May 14, 2021 01:07