You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameNicotine
Accession NumberDB00184  (APRD00200, DB09463, EXPT02315)
TypeSmall Molecule
GroupsApproved
Description

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. [PubChem]

Structure
Thumb
Synonyms
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(±)-nicotine
(R,S)-nicotine
(RS)-nicotine
Nicotin
Nikotin
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nicorette Invisipatchpatch25 mgtransdermalMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicotine Un1654liquid1 L/LoralNicobrand Ltd1997-07-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotrolinhalant4 mg/1respiratory (inhalation)Pharmacia and Upjohn Company1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotrolinhalant4 mg/1respiratory (inhalation)Physicians Total Care, Inc.2004-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotrolspray, metered10 mg/mLnasalPharmacia and Upjohn Company1996-05-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotrol (professional Sample)inhalant4 mg/1respiratory (inhalation)U.S. Pharmaceuticals1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotrol (professional Sample)inhalant4 mg/1respiratory (inhalation)US Pharmaceuticals1997-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription ProductsNot Available
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
American Fare Nicotine Transdermal Systempatch, extended release14 mg/1transdermalNovartis Consumer Health, Inc.2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinegum, chewing4 mg/1oralBJWC2007-05-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2007-05-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2008-09-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinelozenge2 mg/1oralBJWC2006-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinegum, chewing4 mg/1oralBJWC2006-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2006-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Nicotine Polacrilexlozenge4 mg/1oralBJWC2006-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2006-12-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinegum, chewing4 mg/1oralAmerican Sales Company2005-02-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinelozenge4 mg/1oralAmerican Sales Company2006-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2008-08-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinegum, chewing4 mg/1oralAmerican Sales Company2008-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2005-02-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Mini Nicotine Polacrilexlozenge4 mg/1oralAmerican Sales Company2013-06-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotinelozenge2 mg/1oralAmerican Sales Company2013-06-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotinegum, chewing4 mg/1oralAmerican Sales Company2006-12-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotinelozenge2 mg/1oralAmerican Sales Company2006-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotine Polacrilexgum, chewing4 mg/1oralAmerican Sales Company2012-09-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotine Polacrilexgum, chewing2 mg/1oralAmerican Sales Company2012-09-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotine Transdermal System Step 1patch, extended release21 mg/1transdermalNovartis Consumer Health, Inc.2007-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotine Transdermal System Step 2patch, extended release14 mg/1transdermalNovartis Consumer Health, Inc.2007-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Nicotine Transdermal System Step 3patch, extended release7 mg/1transdermalNovartis Consumer Health, Inc.2007-12-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinelozenge2 mg/1oralSupervalu Inc2006-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinelozenge4 mg/1oralSupervalu Inc2006-03-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinelozenge4 mg/1oralSupervalu Inc2012-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinelozenge2 mg/1oralSupervalu Inc2012-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2007-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2005-03-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2011-10-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2006-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2009-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2008-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2013-02-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2005-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2005-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2006-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2008-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2013-02-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc1990-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2007-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2009-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2005-03-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Exchange Select Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2007-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2014-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2005-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen1991-09-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2013-07-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2007-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2007-09-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-01-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-11-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2007-10-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2014-01-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-10-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2014-12-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2014-03-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2014-09-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2005-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2013-08-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company1990-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2012-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge2 mg/1oralDispensing Solutions, Inc.2009-11-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2013-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge2 mg/1oralL. Perrigo Company2006-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge4 mg/1oralL. Perrigo Company2013-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company2005-05-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge4 mg/1oralL. Perrigo Company2006-12-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2005-05-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company2013-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2007-03-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge2 mg/1oralL. Perrigo Company2013-04-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinelozenge4 mg/1oralDispensing Solutions, Inc.2006-12-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotinegum, chewing4 mg/1oralL Perrigo Company2005-04-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotine Mintgum, chewing2 mg/1oralL. Perrigo Company1991-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Nicotine Stop Smoking Aidgum, chewing4 mg/1oralL. Perrigo Company2012-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Habitrol Patch Nicotine Transdermal System, Step 1patch, extended release21 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Habitrol Patch Nicotine Transdermal System, Step 2patch, extended release14 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Habitrol Patch Nicotine Transdermal System, Step 3patch, extended release7 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harris Teeter Nicotinelozenge4 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harris Teeter Nicotinelozenge4 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harris Teeter Nicotinelozenge2 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harris Teeter Nicotinelozenge2 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotinegum, chewing4 mg/1oralMc Kesson2014-04-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotinelozenge2 mg/1oralMc Kesson2011-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotinegum, chewing2 mg/1oralMc Kesson2011-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotinelozenge4 mg/1oralMcKesson2013-07-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotine Polacrilexlozenge4 mg/1oralMc Kesson2011-11-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Nicotine Polacrilexlozenge2 mg/1oralMc Kesson2013-06-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthmart Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalMc Kesson2015-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthmart Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalMc Kesson2015-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthmart Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalMc Kesson2015-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Nicotinegum, chewing4 mg/1oralDZA Brands LLC2011-05-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Nicotinelozenge2 mg/1oralDZA Brands LLC2011-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Nicotinegum, chewing2 mg/1oralDZA Brands LLC2011-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge4 mg/1oralH E B2014-07-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing2 mg/1oralH E B2005-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge2 mg/1oralH E B2014-07-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge4 mg/1oralH E B2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing4 mg/1oralH E B2006-10-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing4 mg/1oralH E B2005-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge4 mg/1oralH E B2014-07-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge2 mg/1oralH E B2014-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing2 mg/1oralH E B2006-10-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge2 mg/1oralH E B2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing4 mg/1oralH E B2005-06-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing2 mg/1oralH E B2005-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing2 mg/1oralH E B2007-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge4 mg/1oralH E B2007-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinelozenge2 mg/1oralH E B2007-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
In Control Nicotinegum, chewing4 mg/1oralH E B2007-12-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Quit 2lozenge2 mg/1oralCostco Wholesale Company2014-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Quit 2gum, chewing2 mg/1oralCostco Wholesale Company2012-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Quit 4lozenge4 mg/1oralCostco Wholesale Company2014-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Quit 4gum, chewing4 mg/1oralCostco Wholesale Company2012-05-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kroger Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kroger Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kroger Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinelozenge2 mg/1oralCardinal Health2007-10-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinelozenge4 mg/1oralCardinal Health2014-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2012-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2012-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2005-05-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2007-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinelozenge4 mg/1oralCardinal Health2007-10-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2005-05-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinelozenge2 mg/1oralCardinal Health2014-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2007-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalCardinal Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalCardinal Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalCardinal Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Meijer Nicotine Transdermal System Step 1patch, extended release21 mg/1topicalNovartis Consumer Health2007-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Meijer Nicotine Transdermal System Step 2patch, extended release21 mg/24htopicalNovartis Consumer Health2007-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Meijer Nicotine Transdermal System Step 3patch, extended release7 mg/1topicalNovartis Consumer Health2007-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Mini Nicotinelozenge4 mg/1oralSam's West Inc2015-07-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2015-08-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2015-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2005-10-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2015-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinelozenge4 mg/1oralSam's West Inc2007-09-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2015-07-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2015-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2015-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2005-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2011-06-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoderm Cqpatch, extended release7 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoderm Cqpatch, extended release14 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoderm Cqpatch, extended release21 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoderm Cqpatch, extended release21 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoderm Trd 114mg Nicotine/21patch114 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicoderm Trd 36mg Nicotine/7 Sqcm Patchpatch36 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicoderm Trd 78mg Nicotine/14patch78 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicorelieflozenge4 mg/1oralMajor Pharmaceuticals2007-11-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorelieflozenge2 mg/1oralMajor Pharmaceuticals2007-10-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoreliefgum, chewing4 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoreliefgum, chewing2 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoreliefgum, chewing4 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicoreliefgum, chewing2 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Cinnamon Surgegum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Cinnamon Surgegum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Fresh Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Fresh Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Fruit Chillgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Fruit Chillgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Gum 2mggum2 mgoralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1984-12-311998-08-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicorette Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Originalgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Originalgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Plus 4mggum4 mgoralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1984-12-311998-08-12Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Nicorette Spearmint Burstgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2011-11-152015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette Spearmint Burstgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2011-11-152015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette White Ice Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicorette White Ice Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralHannaford Brothers Company2009-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company1991-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2005-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralWalgreen Company2014-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralSafeway2007-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch21 mg/24htransdermalClinical Solutions Wholesale1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreen Company2010-01-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch14 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralKroger Company2007-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2006-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralWalgreens2011-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralRite Aid Corporation2006-10-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2007-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2005-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralHannaford Brothers Company2006-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company1998-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralCVS Pharmacy2010-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch7 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralKroger Company2007-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2011-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2013-05-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralCVS Pharmacy2009-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralRite Aid Corporation2006-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralWalgreen Company2006-02-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralCVS Pharmacy2006-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2011-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2005-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2013-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralKroger Company2005-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralCVS Pharmacy1998-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralSafeway2006-08-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralWalgreen Company2013-03-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2010-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralRite Aid Corporation2015-02-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralWalgreen Company2013-03-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralCVS Pharmacy2007-09-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralL. Perrigo Company2012-11-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2007-09-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralSafeway2006-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company2011-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2006-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralSafeway2006-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralRite Aid Corporation2015-02-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralCVS Pharmacy2013-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralKroger Company2007-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralCVS Pharmacy2006-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralRite Aid Corporation2013-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralWalgreen Company2006-10-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2011-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc1992-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralSafeway2008-01-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2014-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralKroger Company2007-09-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2011-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreen Company2014-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2005-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralRite Aid Corporation2006-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company2011-08-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2013-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreens2011-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralWalgreen Company2010-01-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralCVS Pharmacy2006-10-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company2007-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2007-09-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralWalgreen Company2007-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralRite Aid Corporation2007-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch21 mg/24htransdermalTYA Pharmaceuticals1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralKroger Company2007-09-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2009-09-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralCVS Pharmacy2010-05-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreen Company2006-02-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralWalgreen Company2009-09-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2010-01-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralHannaford Brothers Company2006-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralKroger Company2010-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralSafeway2008-01-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2006-10-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2006-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreen Company2013-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralSafeway2007-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch14 mg/24htransdermalTYA Pharmaceuticals1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralWalgreens2011-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralCVS Pharmacy2013-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinepatch21 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralKroger Company2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2006-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralWalgreens2011-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralCVS Pharmacy2009-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralRite Aid Corporation2013-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinegum, chewing4 mg/1oralWalgreen Company2007-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2009-09-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralHannaford Brothers Company2006-04-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotinelozenge2 mg/1oralSafeway2006-04-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Minilozenge4 mg/1oralShopko Stores Operating Co., LLC2015-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Minilozenge2 mg/1oralWalgreen Company2013-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Minilozenge2 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Mint Flavorgum, chewing4 mg/1oralMeijer Distribution Inc2005-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Originallozenge4 mg/1oralWalgreens2002-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Originallozenge2 mg/1oralWalgreens2002-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralCVS Pharmacy2014-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralBe Better Networks2008-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralL. Perrigo Company2012-12-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralCVS Pharmacy2005-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-07-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexlozenge4 mg/1oralPerrigo New York Inc2014-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexlozenge2 mg/1oralPerrigo New York Inc2014-03-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexlozenge4 mg/1oralBe Better Networks2008-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexlozenge2 mg/1oralBe Better Networks2008-09-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2010-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2005-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex Stop Smoking Aidgum, chewing4 mg/1oralCVS Pharmacy2005-07-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Fruit Flavorgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Fruit Flavorgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Stop Smoking Aidgum, chewing2 mg/1oralCVS Pharmacy2005-07-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Stop Smoking Aidgum, chewing2 mg/1oralKroger Company2007-01-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWalgreen Company2010-02-152016-08-01Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalSam's West Inc2012-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalApotex Corp1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWalgreens1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalApotex Corp1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWalgreens1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalApotex Corp1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWalgreens1997-10-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal SystemkittransdermalDr. Reddy's Laboratories Limited2015-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWalgreen Company2010-02-152016-12-01Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWalgreen Company2010-02-152016-05-01Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Patch KitkitNovartis Consumer Health, Inc.2004-07-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalChain Drug Marketing Association Inc.1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Preferred Plus Nicotinelozenge2 mg/1oralKinray2014-09-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Preferred Plus Nicotinelozenge4 mg/1oralKinray2014-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Preferred Plus Nicotine Polacrilex Gum, Original Flavorgum, chewing2 mg/1buccalPreferred Plus (Kinray)1999-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rexall Nicotinelozenge4 mg/1oralDolgencorp, LLC2013-08-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rexall Nicotinegum, chewing4 mg/1oralDolgencorp, LLC2011-05-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rexall Nicotinegum, chewing2 mg/1oralDolgencorp, LLC2011-05-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rite Aid Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rite Aid Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rite Aid Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotinelozenge4 mg/1oralRugby Laboratories2014-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotinelozenge2 mg/1oralRugby Laboratories2014-12-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Cinnamon Flavorgum, chewing4 mg/1buccalRugby Laboratories2009-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Cinnamon Flavorgum, chewing2 mg/1buccalRugby Laboratories2009-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Fruit Flavorgum, chewing4 mg/1buccalRugby Laboratories2009-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Fruit Flavorgum, chewing2 mg/1buccalRugby Laboratories2009-07-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Mint Flavorgum, chewing2 mg/1buccalRugby Laboratories2008-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Coated Mint Flavorgum, chewing4 mg/1buccalRugby Laboratories2008-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Mint Flavorgum, chewing4 mg/1buccalRugby Laboratories2004-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Mint Flavorgum, chewing2 mg/1buccalRugby Laboratories2004-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Original Flavorgum, chewing4 mg/1buccalRugby Laboratories1999-03-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rugby Nicotine Polacrilex Gum, Original Flavorgum, chewing2 mg/1buccalRugby Laboratories1999-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Safeway Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Safeway Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Safeway Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Signature Care Nicotinelozenge4 mg/1oralSafeway2015-09-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Signature Care Nicotinelozenge2 mg/1oralSafeway2015-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinelozenge2 mg/1oralSam's West Inc2007-09-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinegum, chewing4 mg/1oralSam's West Inc2012-01-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinelozenge4 mg/1oralSam's West Inc2012-01-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinelozenge4 mg/1oralSam's West Inc2014-05-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinelozenge2 mg/1oralSam's West Inc2012-01-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinegum, chewing2 mg/1oralSam's West Inc2012-01-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinegum, chewing4 mg/1oralSam's West Inc2012-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Nicotinegum, chewing2 mg/1oralSam's West Inc2012-01-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinelozenge4 mg/1oralKmart Corporation2011-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-07-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinegum, chewing2 mg/1oralKmart Corporation2011-02-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinegum, chewing2 mg/1oralKmart Corporation2011-09-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotinelozenge2 mg/1oralKmart Corporation2011-06-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotine Mintgum, chewing2 mg/1oralKmart Corporation2011-06-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotine Polacrilexlozenge4 mg/1oralKmart Corporation2011-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Nicotine Polacrilexlozenge2 mg/1oralKmart Corporation2011-06-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aidlozenge2 mg/1oralPublix Super Markets Inc2006-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aidgum, chewing4 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aidgum, chewing2 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aidlozenge4 mg/1oralPublix Super Markets Inc2006-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aidgum, chewing4 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Stop Smoking Aid Nicotinegum, chewing2 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2006-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing2 mg/1oralTYA Pharmaceuticals2005-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2005-06-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2005-06-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinelozenge4 mg/1oralMc Kesson2008-04-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinelozenge2 mg/1oralMc Kesson2008-05-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2005-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2006-12-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2005-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinelozenge2 mg/1oralTopco Associates LLC2013-02-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2005-04-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2006-12-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2005-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2010-01-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2013-02-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinelozenge2 mg/1oralTopco Associates LLC2009-09-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2006-12-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2005-04-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2013-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2005-04-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2006-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotine Polacrilexlozenge2 mg/1oralTopco Associates LLC1998-06-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Nicotine Stop Smoking Aidgum, chewing4 mg/1oralTopco Associates LLC2010-01-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinelozenge2 mg/1oralTarget Corporation2013-03-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2010-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2009-07-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2011-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinelozenge4 mg/1oralTarget Corporation2013-03-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2013-08-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinelozenge4 mg/1oralTarget Corporation2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2011-02-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2011-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinelozenge2 mg/1oralTarget Corporation2009-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2010-03-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2011-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2013-08-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotine Polacrilexlozenge2 mg/1oralTarget Corporation2011-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Nicotine Polacrilexlozenge4 mg/1oralTarget Corporation2011-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotinegum, chewing4 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotinegum, chewing4 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotine Polacrilexgum, chewing4 mg/1oralNiconovum Usa Inc.2012-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2012-06-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International Brands
NameCompany
HabitrolNot Available
NicodermNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nicotine polacrilex
ThumbNot applicableDBSALT001599
Categories
CAS number54-11-5
WeightAverage: 162.2316
Monoisotopic: 162.115698458
Chemical FormulaC10H14N2
InChI KeyInChIKey=SNICXCGAKADSCV-UHFFFAOYSA-N
InChI
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
IUPAC Name
3-(1-methylpyrrolidin-2-yl)pyridine
SMILES
CN1CCCC1C1=CN=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassNot Available
Sub ClassNot Available
Direct ParentAlkaloids and derivatives
Alternative Parents
Substituents
  • Nicotine
  • Alkaloid or derivatives
  • Pyrrolidinylpyridine
  • Aralkylamine
  • N-alkylpyrrolidine
  • Pyridine
  • Heteroaromatic compound
  • Pyrrolidine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
PharmacodynamicsNicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.
Mechanism of actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
AbsorptionAbsorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Volume of distribution
  • 2 to 3 L/kg
Protein bindingLess than 5%
Metabolism

Primarily hepatic, cotinine is the primary metabolite.

SubstrateEnzymesProduct
Nicotine
Not Available
N-MethylnicotiniumDetails
Nicotine
Nicotine imineDetails
Nicotine
Not Available
CotinineDetails
Nicotine
Not Available
NornicotineDetails
Nicotine
Nicotine glucuronideDetails
Nicotine
Not Available
NorcotinineDetails
Nicotine
Nicotine-1'-N-oxideDetails
Nicotine
Not Available
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneDetails
Nicotine
Not Available
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanolDetails
Nicotine imine
CotinineDetails
Cotinine
Not Available
Cotinine N-oxideDetails
Cotinine
3'-HydroxycotinineDetails
Cotinine
Not Available
NornicotineDetails
Cotinine
Nicotine-1'-N-oxideDetails
Cotinine
Cotinine glucuronideDetails
Route of eliminationAbout 10% of the nicotine absorbed is excreted unchanged in the urine.
Half lifeCotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours
Clearance
  • 1.2 L/min [healthy adult smoker]
ToxicitySymptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9748
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.5
P-glycoprotein inhibitor INon-inhibitor0.8998
P-glycoprotein inhibitor IINon-inhibitor0.9368
Renal organic cation transporterInhibitor0.6868
CYP450 2C9 substrateNon-substrate0.7998
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.6347
CYP450 2C9 inhibitorNon-inhibitor0.8433
CYP450 2D6 inhibitorNon-inhibitor0.8838
CYP450 2C19 inhibitorNon-inhibitor0.8543
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7589
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9626
BiodegradationNot ready biodegradable0.9478
Rat acute toxicity3.4798 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8851
hERG inhibition (predictor II)Non-inhibitor0.7978
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novartis consumer health inc
  • Sanofi aventis us llc
  • Aveva drug delivery systems inc
  • Mcneil consumer healthcare
  • Pharmacia and upjohn co
  • Pfizer inc
  • Glaxosmithkline
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Perrigo co
  • Perrigo r and d co
  • Watson laboratories inc
  • Glaxosmithkline consumer healthcare
Packagers
Dosage forms
FormRouteStrength
Patch, extended releasetransdermal14 mg/1
Patch, extended releasetransdermal21 mg/1
Patch, extended releasetransdermal7 mg/1
Gum, chewingoral2 mg/1
Gum, chewingoral4 mg/1
Lozengeoral2 mg/1
Lozengeoral4 mg/1
Patch, extended releasetransdermal21 mg/24h
Patch, extended releasetransdermal14 mg/24h
Patch, extended releasetransdermal7 mg/24h
Patch, extended releasetopical21 mg/1
Patch, extended releasetopical7 mg/1
Patchtransdermal114 mg
Patchtransdermal36 mg
Patchtransdermal78 mg
Gumoral2 mg
Patchtransdermal25 mg
Gumoral4 mg
Patchtransdermal14 mg/24h
Patchtransdermal21 mg/24h
Patchtransdermal7 mg/24h
Kittransdermal
Kit
Liquidoral1 L/L
Inhalantrespiratory (inhalation)4 mg/1
Spray, meterednasal10 mg/mL
Gum, chewingbuccal2 mg/1
Gum, chewingbuccal4 mg/1
Patch, extended releasetopical21 mg/24h
Patch, extended releasetopical14 mg/24h
Patch, extended releasetopical7 mg/24h
Prices
Unit descriptionCostUnit
Nicotrol 168 10 mg Inhalant Inhaler223.5USD inhaler
Nicotine 30 21 mg/24hr Patches Box206.52USD box
Nicotine 30 14 mg/24hr Patches Box196.27USD box
Nicotrol NS 10 mg/ml Solution 10ml Bottle55.88USD bottle
Nicotine polacrilex powder11.25USD g
Nicotrol ns 10 mg/ml spray5.37USD ml
Nicoderm cq 21 mg/24hr patch4.08USD patch
Nicoderm cq 14 mg/24hr patch3.52USD patch
Nicoderm cq 7 mg/24hr patch3.52USD patch
Nicotine 11 mg/24hr patch3.14USD patch
Nicotine 22 mg/24hr patch3.14USD patch
Nicotine transdermal system1.83USD each
Nicotrol cartridge inhaler1.28USD each
Commit 2 mg lozenge0.55USD lozenge
Commit 4 mg lozenge0.55USD lozenge
Nicorette 4 mg chewing gum0.52USD each
Nicorette 2 mg chewing gum0.45USD each
Thrive nicotine 2 mg gum0.42USD each
Thrive nicotine 4 mg gum0.42USD each
CVS Pharmacy nicotine 4 mg chewing gum0.38USD each
CVS Pharmacy nicotine 2 mg chewing gum0.34USD each
Nicotine 4 mg chewing gum0.3USD each
Nicotine 2 mg chewing gum0.25USD each
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada13330511994-11-152011-11-15
United States55012361993-06-082010-06-08
United States56562551994-08-122014-08-12
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point-79 °CPhysProp
boiling point247 °CPhysProp
water solubility1E+006 mg/LSEIDELL,A (1941)
logP1.17HANSCH,C ET AL. (1995)
logS0.79ADME Research, USCD
Caco2 permeability-4.71ADME Research, USCD
pKa3.1TOMLIN,C (1997); pKa1
Predicted Properties
PropertyValueSource
Water Solubility93.3 mg/mLALOGPS
logP0.87ALOGPS
logP1.16ChemAxon
logS-0.24ALOGPS
pKa (Strongest Basic)8.86ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity49.66 m3·mol-1ChemAxon
Polarizability18.62 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
SpectraNot Available
References
Synthesis Reference

Charles G. Chavdarian, Edward B. Sanders, “Process for the preparation of optically active nicotine analogs.” U.S. Patent US4321387, issued September, 1959.

US4321387
General References
  1. Nolley EP, Kelley BM: Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicol Teratol. 2007 Jan-Feb;29(1):47-56. Epub 2006 Oct 4. Pubmed
  2. de Leon J, Tracy J, McCann E, McGrory A, Diaz FJ: Schizophrenia and tobacco smoking: a replication study in another US psychiatric hospital. Schizophr Res. 2002 Jul 1;56(1-2):55-65. Pubmed
  3. de Leon J, Dadvand M, Canuso C, White AO, Stanilla JK, Simpson GM: Schizophrenia and smoking: an epidemiological survey in a state hospital. Am J Psychiatry. 1995 Mar;152(3):453-5. Pubmed
  4. Aguilar MC, Gurpegui M, Diaz FJ, de Leon J: Nicotine dependence and symptoms in schizophrenia: naturalistic study of complex interactions. Br J Psychiatry. 2005 Mar;186:215-21. Pubmed
External Links
ATC CodesN07BA01
AHFS Codes
  • 12:92.00
  • 24:06.92
  • 88:08.00
  • 92:02.00*
PDB Entries
FDA labelDownload (11.2 MB)
MSDSDownload (77.6 KB)
Interactions
Drug Interactions
Drug
AdenosineNicotine may increase the atrioventricular blocking (AV block) activities of Adenosine.
AmiodaroneThe metabolism of Nicotine can be decreased when combined with Amiodarone.
AmobarbitalThe metabolism of Nicotine can be increased when combined with Amobarbital.
CimetidineThe serum concentration of Nicotine can be increased when it is combined with Cimetidine.
Cyproterone acetateThe serum concentration of Nicotine can be decreased when it is combined with Cyproterone acetate.
DisulfiramThe metabolism of Nicotine can be decreased when combined with Disulfiram.
Hydroxyprogesterone caproateThe metabolism of Nicotine can be increased when combined with Hydroxyprogesterone caproate.
IsoniazidThe metabolism of Nicotine can be decreased when combined with Isoniazid.
KetoconazoleThe metabolism of Nicotine can be decreased when combined with Ketoconazole.
LetrozoleThe metabolism of Nicotine can be decreased when combined with Letrozole.
MethoxsalenThe metabolism of Nicotine can be decreased when combined with Methoxsalen.
PentobarbitalThe metabolism of Nicotine can be increased when combined with Pentobarbital.
PhenobarbitalThe metabolism of Nicotine can be increased when combined with Phenobarbital.
RifampicinThe metabolism of Nicotine can be increased when combined with Rifampicin.
SecobarbitalThe metabolism of Nicotine can be increased when combined with Secobarbital.
TranylcypromineThe metabolism of Nicotine can be decreased when combined with Tranylcypromine.
VareniclineThe risk or severity of adverse effects can be increased when Varenicline is combined with Nicotine.
Food InteractionsNot Available

Targets

1. Neuronal acetylcholine receptor subunit alpha-4

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-4 P43681 Details

References:

  1. Espeseth T, Endestad T, Rootwelt H, Reinvang I: Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience. 2007 Jul 29;147(4):974-85. Epub 2007 Jun 27. Pubmed
  2. Winterer G, Musso F, Konrad A, Vucurevic G, Stoeter P, Sander T, Gallinat J: Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum Mol Genet. 2007 Sep 15;16(18):2165-74. Epub 2007 Jul 5. Pubmed
  3. Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):596-604. Pubmed
  4. Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J: Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7. Epub 2006 Dec 4. Pubmed
  5. De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. Pubmed
  6. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  7. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  8. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  9. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

2. Neuronal acetylcholine receptor subunit alpha-7

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-7 P36544 Details

References:

  1. Mexal S, Jenkins PM, Lautner MA, Iacob E, Crouch EL, Stitzel JA: alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion. J Biol Chem. 2007 May 4;282(18):13220-7. Epub 2007 Mar 14. Pubmed
  2. Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R: Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006 Jun;63(6):630-8. Pubmed
  3. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  4. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  5. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  6. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

3. Neuronal acetylcholine receptor subunit beta-2

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit beta-2 P17787 Details

References:

  1. Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):596-604. Pubmed
  2. De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. Pubmed
  3. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  4. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  5. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  6. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

4. Neuronal acetylcholine receptor subunit alpha-2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-2 Q15822 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed
  5. Sullivan PF, Neale BM, van den Oord E, Miles MF, Neale MC, Bulik CM, Joyce PR, Straub RE, Kendler KS: Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):23-36. Pubmed

5. Neuronal acetylcholine receptor subunit alpha-3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-3 P32297 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

6. Neuronal acetylcholine receptor subunit alpha-5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-5 P30532 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

7. Neuronal acetylcholine receptor subunit alpha-6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-6 Q15825 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

8. Neuronal acetylcholine receptor subunit alpha-9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-9 Q9UGM1 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

9. Neuronal acetylcholine receptor subunit alpha-10

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit alpha-10 Q9GZZ6 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

10. Neuronal acetylcholine receptor subunit beta-3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit beta-3 Q05901 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

11. Neuronal acetylcholine receptor subunit beta-4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Neuronal acetylcholine receptor subunit beta-4 P30926 Details

References:

  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. Epub 2009 Jan 22. Pubmed
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. Pubmed
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. Epub 2010 Apr 16. Pubmed
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence – human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. Pubmed

12. Cytochrome P450 19A1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Aromatase P11511 Details

References:

  1. Barbieri RL, Gochberg J, Ryan KJ: Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin Invest. 1986 Jun;77(6):1727-33. Pubmed

13. Choline O-acetyltransferase

Kind: Protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Choline O-acetyltransferase P28329 Details

References:

  1. FAHMY AR, RYMAN BE, WALSH EO: The inhibition of choline acetylase by nicotine. J Pharm Pharmacol. 1954 Sep;6(9):607-9. Pubmed

Enzymes

1. Cytochrome P450 2A6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2A6 P11509 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  2. Lexicomp.

2. Cytochrome P450 2E1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2E1 P05181 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  2. Lexicomp.

3. Cytochrome P450 2A13

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2A13 Q16696 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 2B6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 1A1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inducer

Components

Name UniProt ID Details
Cytochrome P450 1A1 P04798 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

6. Cytochrome P450 1A2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inducer

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

7. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

8. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

9. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

10. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

11. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

12. Amine oxidase [flavin-containing] A

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] A P21397 Details

References:

  1. Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2011 Jun 2. Pubmed
  2. Leroy C, Bragulat V, Berlin I, Gregoire MC, Bottlaender M, Roumenov D, Dolle F, Bourgeois S, Penttila J, Artiges E, Martinot JL, Trichard C: Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone. J Clin Psychopharmacol. 2009 Feb;29(1):86-8. Pubmed

13. Amine oxidase [flavin-containing] B

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Amine oxidase [flavin-containing] B P27338 Details

References:

  1. Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2011 Jun 2. Pubmed

Transporters

1. Solute carrier family 22 member 2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 2 O15244 Details

References:

  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. Pubmed
  2. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. Pubmed
  3. Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. Pubmed

2. Solute carrier family 22 member 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 1 O15245 Details

References:

  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. Pubmed
  2. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. Pubmed
  3. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. Pubmed

3. Solute carrier family 22 member 3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 3 O75751 Details

References:

  1. Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. Pubmed

4. Solute carrier family 22 member 5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 5 O76082 Details

References:

  1. Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. Pubmed
  2. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. Pubmed
  3. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. Pubmed

5. Solute carrier family 22 member 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Solute carrier family 22 member 4 Q9H015 Details

References:

  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. Pubmed
  2. Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. Pubmed

Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on December 03, 2015 13:38