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Identification
NameNicotine
Accession NumberDB00184  (APRD00200, EXPT02315, DB09463)
TypeSmall Molecule
GroupsApproved
Description

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. [PubChem]

Structure
Thumb
Synonyms
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(±)-nicotine
(R,S)-nicotine
(RS)-nicotine
Nicotin
Nikotin
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nicorette Invisipatchpatch25 mgtransdermalMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Nicotrolinhalant4 mg/1respiratory (inhalation)Pharmacia and Upjohn Company1997-05-02Not applicableUs
Nicotrolinhalant4 mg/1respiratory (inhalation)Physicians Total Care, Inc.2004-08-04Not applicableUs
Nicotrolspray, metered10 mg/mLnasalPharmacia and Upjohn Company1996-05-22Not applicableUs
Nicotrol (professional Sample)inhalant4 mg/1respiratory (inhalation)U.S. Pharmaceuticals1997-05-02Not applicableUs
Nicotrol (professional Sample)inhalant4 mg/1respiratory (inhalation)US Pharmaceuticals1997-05-02Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
American Fare Nicotine Transdermal Systempatch, extended release14 mg/1transdermalNovartis Consumer Health, Inc.2012-01-02Not applicableUs
Berkley and Jensen Nicotinegum, chewing4 mg/1oralBJWC2006-01-18Not applicableUs
Berkley and Jensen Nicotinelozenge2 mg/1oralBJWC2006-05-02Not applicableUs
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2006-01-19Not applicableUs
Berkley and Jensen Nicotinegum, chewing4 mg/1oralBJWC2007-05-31Not applicableUs
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2007-05-31Not applicableUs
Berkley and Jensen Nicotinegum, chewing2 mg/1oralBJWC2008-09-21Not applicableUs
Berkley and Jensen Nicotine Polacrilexlozenge4 mg/1oralBJWC2006-05-02Not applicableUs
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2006-12-12Not applicableUs
Care One Nicotinegum, chewing4 mg/1oralAmerican Sales Company2005-02-08Not applicableUs
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2008-08-29Not applicableUs
Care One Nicotinegum, chewing2 mg/1oralAmerican Sales Company2005-02-08Not applicableUs
Care One Nicotinelozenge4 mg/1oralAmerican Sales Company2006-03-07Not applicableUs
Care One Nicotinegum, chewing4 mg/1oralAmerican Sales Company2008-07-25Not applicableUs
Careone Mini Nicotine Polacrilexlozenge4 mg/1oralAmerican Sales Company2013-06-22Not applicableUs
Careone Nicotinegum, chewing4 mg/1oralAmerican Sales Company2006-12-18Not applicableUs
Careone Nicotinelozenge2 mg/1oralAmerican Sales Company2013-06-28Not applicableUs
Careone Nicotinelozenge2 mg/1oralAmerican Sales Company2006-03-07Not applicableUs
Careone Nicotine Polacrilexgum, chewing4 mg/1oralAmerican Sales Company2012-09-27Not applicableUs
Careone Nicotine Polacrilexgum, chewing2 mg/1oralAmerican Sales Company2012-09-22Not applicableUs
Careone Nicotine Transdermal System Step 1patch, extended release21 mg/1transdermalNovartis Consumer Health, Inc.2007-11-02Not applicableUs
Careone Nicotine Transdermal System Step 2patch, extended release14 mg/1transdermalNovartis Consumer Health, Inc.2007-11-02Not applicableUs
Careone Nicotine Transdermal System Step 3patch, extended release7 mg/1transdermalNovartis Consumer Health, Inc.2007-12-07Not applicableUs
Equaline Nicotinelozenge2 mg/1oralSupervalu Inc2006-03-28Not applicableUs
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-18Not applicableUs
Equaline Nicotinelozenge4 mg/1oralSupervalu Inc2012-03-03Not applicableUs
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-08Not applicableUs
Equaline Nicotinelozenge4 mg/1oralSupervalu Inc2006-03-28Not applicableUs
Equaline Nicotinelozenge2 mg/1oralSupervalu Inc2012-02-21Not applicableUs
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-23Not applicableUs
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-17Not applicableUs
Equaline Nicotinegum, chewing2 mg/1oralSupervalu Inc2008-09-17Not applicableUs
Equaline Nicotinegum, chewing4 mg/1oralSupervalu Inc2008-09-08Not applicableUs
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc1990-06-15Not applicableUs
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2009-09-10Not applicableUs
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2005-03-22Not applicableUs
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2009-09-10Not applicableUs
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2006-12-15Not applicableUs
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2005-03-08Not applicableUs
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2005-03-09Not applicableUs
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2013-02-14Not applicableUs
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2011-10-04Not applicableUs
Equate Nicotinelozenge4 mg/1oralWal Mart Stores Inc2006-12-15Not applicableUs
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2008-10-14Not applicableUs
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2008-10-14Not applicableUs
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2005-03-08Not applicableUs
Equate Nicotinelozenge2 mg/1oralWal Mart Stores Inc2013-02-14Not applicableUs
Equate Nicotinegum, chewing4 mg/1oralWal Mart Stores Inc2007-05-09Not applicableUs
Equate Nicotinegum, chewing2 mg/1oralWal Mart Stores Inc2007-05-09Not applicableUs
Exchange Select Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2007-11-05Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2014-03-19Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2007-01-30Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2007-09-05Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2013-08-02Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2007-10-10Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-11-27Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2013-07-22Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2005-08-31Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-10-22Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen2014-01-23Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2014-12-02Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2014-01-23Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2005-08-31Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge4 mg/1oralAmerisource Bergen2014-09-07Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing2 mg/1oralAmerisource Bergen2005-08-31Not applicableUs
Good Neighbor Pharmacy Nicotinelozenge2 mg/1oralAmerisource Bergen2014-08-14Not applicableUs
Good Neighbor Pharmacy Nicotinegum, chewing4 mg/1oralAmerisource Bergen1991-09-18Not applicableUs
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2007-03-07Not applicableUs
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company1990-07-15Not applicableUs
Good Sense Nicotinegum, chewing4 mg/1oralL Perrigo Company2005-04-22Not applicableUs
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2012-01-19Not applicableUs
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2013-05-14Not applicableUs
Good Sense Nicotinelozenge4 mg/1oralDispensing Solutions, Inc.2006-12-27Not applicableUs
Good Sense Nicotinelozenge2 mg/1oralL. Perrigo Company2006-07-25Not applicableUs
Good Sense Nicotinelozenge2 mg/1oralDispensing Solutions, Inc.2009-11-28Not applicableUs
Good Sense Nicotinelozenge4 mg/1oralL. Perrigo Company2013-04-27Not applicableUs
Good Sense Nicotinelozenge4 mg/1oralL. Perrigo Company2006-12-27Not applicableUs
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company2005-05-06Not applicableUs
Good Sense Nicotinegum, chewing2 mg/1oralL. Perrigo Company2005-05-06Not applicableUs
Good Sense Nicotinegum, chewing4 mg/1oralL. Perrigo Company2013-05-14Not applicableUs
Good Sense Nicotinelozenge2 mg/1oralL. Perrigo Company2013-04-22Not applicableUs
Good Sense Nicotine Mintgum, chewing2 mg/1oralL. Perrigo Company1991-04-15Not applicableUs
Good Sense Nicotine Stop Smoking Aidgum, chewing4 mg/1oralL. Perrigo Company2012-01-19Not applicableUs
Habitrol Patch Nicotine Transdermal System, Step 1patch, extended release21 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs
Habitrol Patch Nicotine Transdermal System, Step 2patch, extended release14 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs
Habitrol Patch Nicotine Transdermal System, Step 3patch, extended release7 mg/24htransdermalNovartis Consumer Health, Inc.2003-02-26Not applicableUs
Harris Teeter Nicotinelozenge4 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs
Harris Teeter Nicotinelozenge2 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs
Harris Teeter Nicotinelozenge4 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs
Harris Teeter Nicotinelozenge2 mg/1oralHarris Teeter, LLC2015-06-04Not applicableUs
Health Mart Nicotinelozenge4 mg/1oralMcKesson2013-07-02Not applicableUs
Health Mart Nicotinegum, chewing4 mg/1oralMc Kesson2014-04-02Not applicableUs
Health Mart Nicotinegum, chewing2 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Nicotine Polacrilexlozenge2 mg/1oralMc Kesson2013-06-10Not applicableUs
Health Mart Nicotine Polacrilexlozenge4 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Nicotine Polacrilexlozenge2 mg/1oralMc Kesson2011-11-21Not applicableUs
Healthmart Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalMc Kesson2015-08-14Not applicableUs
Healthmart Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalMc Kesson2015-08-14Not applicableUs
Healthmart Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalMc Kesson2015-08-14Not applicableUs
Healthy Accents Nicotinegum, chewing4 mg/1oralDZA Brands LLC2011-05-07Not applicableUs
Healthy Accents Nicotinelozenge2 mg/1oralDZA Brands LLC2011-06-06Not applicableUs
Healthy Accents Nicotinegum, chewing2 mg/1oralDZA Brands LLC2011-06-06Not applicableUs
In Control Nicotinelozenge4 mg/1oralH E B2010-02-15Not applicableUs
In Control Nicotinegum, chewing4 mg/1oralH E B2007-12-13Not applicableUs
In Control Nicotinegum, chewing2 mg/1oralH E B2005-06-15Not applicableUs
In Control Nicotinegum, chewing4 mg/1oralH E B2005-06-15Not applicableUs
In Control Nicotinelozenge2 mg/1oralH E B2014-07-23Not applicableUs
In Control Nicotinelozenge2 mg/1oralH E B2014-06-06Not applicableUs
In Control Nicotinegum, chewing4 mg/1oralH E B2006-10-13Not applicableUs
In Control Nicotinelozenge2 mg/1oralH E B2010-02-15Not applicableUs
In Control Nicotinelozenge4 mg/1oralH E B2014-07-28Not applicableUs
In Control Nicotinegum, chewing2 mg/1oralH E B2005-06-06Not applicableUs
In Control Nicotinegum, chewing2 mg/1oralH E B2006-10-13Not applicableUs
In Control Nicotinegum, chewing4 mg/1oralH E B2005-06-15Not applicableUs
In Control Nicotinelozenge4 mg/1oralH E B2014-07-23Not applicableUs
In Control Nicotinegum, chewing2 mg/1oralH E B2007-12-13Not applicableUs
In Control Nicotinelozenge4 mg/1oralH E B2007-07-25Not applicableUs
In Control Nicotinelozenge2 mg/1oralH E B2007-07-25Not applicableUs
Kirkland Signature Quit 2lozenge2 mg/1oralCostco Wholesale Company2014-09-12Not applicableUs
Kirkland Signature Quit 2gum, chewing2 mg/1oralCostco Wholesale Company2012-05-15Not applicableUs
Kirkland Signature Quit 4lozenge4 mg/1oralCostco Wholesale Company2014-09-12Not applicableUs
Kirkland Signature Quit 4gum, chewing4 mg/1oralCostco Wholesale Company2012-05-07Not applicableUs
Kroger Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Kroger Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Kroger Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2007-01-04Not applicableUs
Leader Nicotinelozenge2 mg/1oralCardinal Health2014-11-10Not applicableUs
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2012-04-18Not applicableUs
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2012-04-11Not applicableUs
Leader Nicotinelozenge4 mg/1oralCardinal Health2014-11-10Not applicableUs
Leader Nicotinelozenge4 mg/1oralCardinal Health2007-10-05Not applicableUs
Leader Nicotinelozenge2 mg/1oralCardinal Health2007-10-05Not applicableUs
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2005-05-25Not applicableUs
Leader Nicotinegum, chewing4 mg/1oralCardinal Health2007-01-04Not applicableUs
Leader Nicotinegum, chewing2 mg/1oralCardinal Health2005-05-25Not applicableUs
Leader Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalCardinal Health2012-01-02Not applicableUs
Leader Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalCardinal Health2012-01-02Not applicableUs
Leader Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalCardinal Health2012-01-02Not applicableUs
Meijer Nicotine Transdermal System Step 1patch, extended release21 mg/1topicalNovartis Consumer Health2007-11-05Not applicableUs
Meijer Nicotine Transdermal System Step 2patch, extended release21 mg/24htopicalNovartis Consumer Health2007-11-05Not applicableUs
Meijer Nicotine Transdermal System Step 3patch, extended release7 mg/1topicalNovartis Consumer Health2007-11-05Not applicableUs
Members Mark Mini Nicotinelozenge4 mg/1oralSam's West Inc2015-07-21Not applicableUs
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2015-05-28Not applicableUs
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2015-07-29Not applicableUs
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2005-09-30Not applicableUs
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2015-08-07Not applicableUs
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2011-06-22Not applicableUs
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2015-05-28Not applicableUs
Members Mark Nicotinegum, chewing2 mg/1oralSam's West Inc2015-06-24Not applicableUs
Members Mark Nicotinelozenge4 mg/1oralSam's West Inc2007-09-07Not applicableUs
Members Mark Nicotinelozenge2 mg/1oralSam's West Inc2015-07-21Not applicableUs
Members Mark Nicotinegum, chewing4 mg/1oralSam's West Inc2005-10-05Not applicableUs
Nicoderm Cqpatch, extended release7 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs
Nicoderm Cqpatch, extended release14 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs
Nicoderm Cqpatch, extended release21 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs
Nicoderm Cqpatch, extended release21 mg/24htransdermalGlaxo Smith Kline Consumer Healthcare Lp2011-05-12Not applicableUs
Nicoderm Trd 114mg Nicotine/21patch114 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada
Nicoderm Trd 36mg Nicotine/7 Sqcm Patchpatch36 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada
Nicoderm Trd 78mg Nicotine/14patch78 mgtransdermalMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1992-12-311998-08-12Canada
Nicorelieflozenge4 mg/1oralMajor Pharmaceuticals2007-11-19Not applicableUs
Nicorelieflozenge2 mg/1oralMajor Pharmaceuticals2007-10-23Not applicableUs
Nicoreliefgum, chewing4 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs
Nicoreliefgum, chewing2 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs
Nicoreliefgum, chewing4 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs
Nicoreliefgum, chewing2 mg/1oralMajor Pharmaceuticals2005-04-12Not applicableUs
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-03-01Not applicableUs
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-10-19Not applicableUs
Nicorettelozenge4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2010-03-01Not applicableUs
Nicorette Cinnamon Surgegum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Cinnamon Surgegum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Fresh Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Fresh Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Fruit Chillgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-09-14Not applicableUs
Nicorette Fruit Chillgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-09-14Not applicableUs
Nicorette Gum 2mggum2 mgoralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1984-12-311998-08-12Canada
Nicorette Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Originalgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Originalgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette Plus 4mggum4 mgoralMerrell Dow Pharmaceuticals (Canada) Inc., Division Of Mmdc1984-12-311998-08-12Canada
Nicorette Spearmint Burstgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2011-11-152015-12-29Us
Nicorette Spearmint Burstgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2011-11-152015-12-29Us
Nicorette White Ice Mintgum, chewing4 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicorette White Ice Mintgum, chewing2 mg/1oralGlaxo Smith Kline Consumer Healthcare Lp2009-06-29Not applicableUs
Nicotinepatch21 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs
Nicotinelozenge4 mg/1oralCVS Pharmacy2009-10-01Not applicableUs
Nicotinelozenge4 mg/1oralSafeway2006-04-13Not applicableUs
Nicotinegum, chewing4 mg/1oralSafeway2006-08-17Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2010-09-14Not applicableUs
Nicotinegum, chewing2 mg/1oralKroger Company2005-12-15Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2007-04-27Not applicableUs
Nicotinegum, chewing2 mg/1oralKroger Company2007-04-27Not applicableUs
Nicotinelozenge2 mg/1oralWalgreen Company2009-09-15Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2013-05-11Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company1998-06-23Not applicableUs
Nicotinelozenge4 mg/1oralWalgreen Company2006-02-23Not applicableUs
Nicotinelozenge2 mg/1oralWalgreens2011-07-14Not applicableUs
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2011-12-14Not applicableUs
Nicotinelozenge4 mg/1oralWalgreens2011-07-14Not applicableUs
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2009-09-16Not applicableUs
Nicotinegum, chewing4 mg/1oralWalgreen Company2014-03-18Not applicableUs
Nicotinelozenge2 mg/1oralHannaford Brothers Company2006-04-21Not applicableUs
Nicotinegum, chewing4 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2006-10-31Not applicableUs
Nicotinelozenge2 mg/1oralCVS Pharmacy2009-10-01Not applicableUs
Nicotinelozenge4 mg/1oralCVS Pharmacy2013-02-13Not applicableUs
Nicotinepatch14 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs
Nicotinegum, chewing4 mg/1oralSafeway2008-01-22Not applicableUs
Nicotinepatch21 mg/24htransdermalTYA Pharmaceuticals1997-10-20Not applicableUs
Nicotinegum, chewing2 mg/1oralSafeway2006-08-14Not applicableUs
Nicotinegum, chewing4 mg/1oralKroger Company2007-02-16Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2011-08-11Not applicableUs
Nicotinegum, chewing4 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs
Nicotinelozenge4 mg/1oralRite Aid Corporation2006-02-24Not applicableUs
Nicotinegum, chewing4 mg/1oralWalgreen Company2007-09-10Not applicableUs
Nicotinelozenge4 mg/1oralWalgreen Company2010-01-12Not applicableUs
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2010-01-15Not applicableUs
Nicotinelozenge2 mg/1oralWalgreens2011-07-14Not applicableUs
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2005-02-01Not applicableUs
Nicotinegum, chewing2 mg/1oralHannaford Brothers Company2006-05-15Not applicableUs
Nicotinepatch7 mg/24htransdermalRugby Laboratories1997-10-20Not applicableUs
Nicotinepatch14 mg/24htransdermalTYA Pharmaceuticals1997-10-20Not applicableUs
Nicotinelozenge4 mg/1oralRite Aid Corporation2013-01-19Not applicableUs
Nicotinegum, chewing2 mg/1oralKroger Company2007-09-15Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company2011-08-11Not applicableUs
Nicotinegum, chewing2 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs
Nicotinelozenge2 mg/1oralRite Aid Corporation2015-02-05Not applicableUs
Nicotinelozenge2 mg/1oralWalgreen Company2006-02-23Not applicableUs
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2005-02-06Not applicableUs
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2013-01-18Not applicableUs
Nicotinegum, chewing4 mg/1oralSafeway2007-07-18Not applicableUs
Nicotinegum, chewing4 mg/1oralRite Aid Corporation2007-12-21Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company2007-04-27Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2011-08-11Not applicableUs
Nicotinegum, chewing2 mg/1oralL. Perrigo Company2012-11-29Not applicableUs
Nicotinegum, chewing4 mg/1oralWalgreen Company2013-03-22Not applicableUs
Nicotinegum, chewing2 mg/1oralWalgreen Company2013-03-22Not applicableUs
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2011-12-14Not applicableUs
Nicotinelozenge4 mg/1oralMeijer Distribution Inc2006-03-01Not applicableUs
Nicotinelozenge4 mg/1oralCVS Pharmacy2006-02-22Not applicableUs
Nicotinelozenge4 mg/1oralCVS Pharmacy2010-05-12Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company2011-08-11Not applicableUs
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2007-09-26Not applicableUs
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc1992-02-21Not applicableUs
Nicotinegum, chewing4 mg/1oralCVS Pharmacy2007-09-15Not applicableUs
Nicotinelozenge2 mg/1oralCVS Pharmacy1998-06-23Not applicableUs
Nicotinegum, chewing2 mg/1oralSafeway2007-07-18Not applicableUs
Nicotinelozenge2 mg/1oralRite Aid Corporation2013-01-19Not applicableUs
Nicotinelozenge2 mg/1oralCVS Pharmacy2013-02-13Not applicableUs
Nicotinegum, chewing2 mg/1oralWalgreen Company2006-10-27Not applicableUs
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2006-03-01Not applicableUs
Nicotinelozenge4 mg/1oralWalgreen Company2014-11-05Not applicableUs
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2013-01-18Not applicableUs
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2014-07-18Not applicableUs
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2007-09-15Not applicableUs
Nicotinegum, chewing2 mg/1oralSafeway2008-01-22Not applicableUs
Nicotinegum, chewing2 mg/1oralRite Aid Corporation2006-10-26Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company1991-05-15Not applicableUs
Nicotinegum, chewing4 mg/1oralKroger Company2007-09-15Not applicableUs
Nicotinelozenge2 mg/1oralWalgreen Company2010-01-12Not applicableUs
Nicotinelozenge4 mg/1oralWalgreens2011-07-14Not applicableUs
Nicotinegum, chewing2 mg/1oralMeijer Distribution Inc2005-01-24Not applicableUs
Nicotinegum, chewing2 mg/1oralWalgreen Company2007-09-10Not applicableUs
Nicotinegum, chewing4 mg/1oralHannaford Brothers Company2009-02-16Not applicableUs
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2009-09-11Not applicableUs
Nicotinegum, chewing4 mg/1oralCVS Pharmacy2006-10-26Not applicableUs
Nicotinelozenge2 mg/1oralCVS Pharmacy2006-02-22Not applicableUs
Nicotinelozenge2 mg/1oralSafeway2006-04-06Not applicableUs
Nicotinelozenge2 mg/1oralRite Aid Corporation2006-02-24Not applicableUs
Nicotinelozenge4 mg/1oralKroger Company2010-09-14Not applicableUs
Nicotinelozenge2 mg/1oralKroger Company2013-05-09Not applicableUs
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2005-07-08Not applicableUs
Nicotinegum, chewing4 mg/1oralHannaford Brothers Company2006-05-15Not applicableUs
Nicotinegum, chewing4 mg/1oralMeijer Distribution Inc2006-10-31Not applicableUs
Nicotinepatch21 mg/24htransdermalClinical Solutions Wholesale1997-10-20Not applicableUs
Nicotinegum, chewing2 mg/1oralCVS Pharmacy2006-10-26Not applicableUs
Nicotinelozenge2 mg/1oralCVS Pharmacy2010-05-12Not applicableUs
Nicotinelozenge4 mg/1oralRite Aid Corporation2015-02-05Not applicableUs
Nicotinegum, chewing4 mg/1oralKroger Company2007-04-27Not applicableUs
Nicotinelozenge2 mg/1oralMeijer Distribution Inc2010-01-15Not applicableUs
Nicotinelozenge4 mg/1oralWalgreen Company2013-01-19Not applicableUs
Nicotine Minilozenge2 mg/1oralShopko Stores Operating Co., LLC2015-05-28Not applicableUs
Nicotine Minilozenge4 mg/1oralShopko Stores Operating Co., LLC2015-06-03Not applicableUs
Nicotine Minilozenge2 mg/1oralWalgreen Company2013-01-19Not applicableUs
Nicotine Minilozenge4 mg/1oralKroger Company2016-04-19Not applicableUs
Nicotine Minilozenge2 mg/1oralKroger Company2016-02-12Not applicableUs
Nicotine Mint Flavorgum, chewing4 mg/1oralMeijer Distribution Inc2005-01-24Not applicableUs
Nicotine Originallozenge4 mg/1oralWalgreens2002-10-31Not applicableUs
Nicotine Originallozenge2 mg/1oralWalgreens2002-10-31Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralBe Better Networks2008-09-10Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs
Nicotine Polacrilexlozenge2 mg/1oralBe Better Networks2008-09-10Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-17Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-07-26Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralPerrigo New York Inc2014-04-09Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralCVS Pharmacy2005-07-08Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralCVS Pharmacy2014-07-18Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2010-02-15Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2010-02-15Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralL. Perrigo Company2012-12-17Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2010-02-15Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2010-02-15Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilexlozenge4 mg/1oralPerrigo New York Inc2014-03-31Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilexlozenge2 mg/1oralPerrigo New York Inc2014-03-31Not applicableUs
Nicotine Polacrilexlozenge4 mg/1oralBe Better Networks2008-09-10Not applicableUs
Nicotine Polacrilexgum, chewing4 mg/1oralKroger Company2005-12-15Not applicableUs
Nicotine Polacrilexgum, chewing2 mg/1oralKroger Company2011-08-04Not applicableUs
Nicotine Polacrilex Stop Smoking Aidgum, chewing4 mg/1oralCVS Pharmacy2005-07-07Not applicableUs
Nicotine Polacrilex, Coated Fruit Flavorgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Coated Fruit Flavorgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-09-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Coated Mint Flavorgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-06-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing4 mg/1buccalChain Drug Consortium, LLC2013-07-01Not applicableUs
Nicotine Polacrilex, Originalgum, chewing2 mg/1buccalChain Drug Consortium, LLC2013-09-01Not applicableUs
Nicotine Stop Smoking Aidgum, chewing2 mg/1oralCVS Pharmacy2005-07-07Not applicableUs
Nicotine Stop Smoking Aidgum, chewing2 mg/1oralKroger Company2007-01-29Not applicableUs
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWalgreen Company2010-02-15Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWalgreens1997-10-20Not applicableUs
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWalgreens1997-10-20Not applicableUs
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWalgreens1997-10-20Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalApotex Corp1997-10-20Not applicableUs
Nicotine Transdermal SystemkittransdermalDr. Reddy's Laboratories Limited2015-05-14Not applicableUs
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalApotex Corp1997-10-20Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalSam's West Inc2012-03-02Not applicableUs
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs
Nicotine Transdermal Systempatch, extended release14 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalApotex Corp1997-10-20Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWal Mart Stores Inc2010-10-19Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalTarget Corporation2000-02-16Not applicableUs
Nicotine Transdermal Systempatch, extended release7 mg/24htransdermalWalgreen Company2010-02-15Not applicableUs
Nicotine Transdermal Systempatch, extended release21 mg/24htransdermalWalgreen Company2010-02-15Not applicableUs
Nicotine Transdermal System Patch KitkitNovartis Consumer Health, Inc.2004-07-21Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalCardinal Health2016-03-31Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Transdermal System Step 1patch, extended release21 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalCardinal Health2016-03-31Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalChain Drug Marketing Association Inc.1999-10-01Not applicableUs
Nicotine Transdermal System Step 2patch, extended release14 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalGolden State Medical Supply, Inc.2015-09-23Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalPreferred Plus (Kinray)1999-10-01Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalCVS Pharmacy2015-08-06Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalCardinal Health2016-03-31Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health, Inc.1999-11-12Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalDr. Reddy's Laboratories Inc.2015-05-14Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalMckesson (Sun Mark)2015-11-02Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalPhysicians Total Care, Inc.2007-09-19Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalThe Kroger Co.2015-08-25Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalCardinal Health (Leader)2015-10-01Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalChain Drug Consortium, LLC1999-10-01Not applicableUs
Nicotine Transdermal System Step 3patch, extended release7 mg/24htransdermalWalgreens Company2015-09-01Not applicableUs
Preferred Plus Nicotinelozenge2 mg/1oralKinray2014-09-29Not applicableUs
Preferred Plus Nicotinelozenge4 mg/1oralKinray2014-10-01Not applicableUs
Preferred Plus Nicotine Polacrilex Gum, Original Flavorgum, chewing2 mg/1buccalPreferred Plus (Kinray)1999-03-15Not applicableUs
Rexall Nicotinegum, chewing2 mg/1oralDolgencorp, LLC2011-05-16Not applicableUs
Rexall Nicotinelozenge4 mg/1oralDolgencorp, LLC2013-08-08Not applicableUs
Rexall Nicotinegum, chewing4 mg/1oralDolgencorp, LLC2011-05-17Not applicableUs
Rite Aid Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Rite Aid Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Rite Aid Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2012-01-02Not applicableUs
Rugby Nicotinelozenge4 mg/1oralRugby Laboratories2014-12-04Not applicableUs
Rugby Nicotinelozenge2 mg/1oralRugby Laboratories2014-12-04Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Cinnamon Flavorgum, chewing4 mg/1buccalRugby Laboratories2009-07-08Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Cinnamon Flavorgum, chewing2 mg/1buccalRugby Laboratories2009-07-08Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Fruit Flavorgum, chewing4 mg/1buccalRugby Laboratories2009-07-08Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Fruit Flavorgum, chewing2 mg/1buccalRugby Laboratories2009-07-08Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Mint Flavorgum, chewing2 mg/1buccalRugby Laboratories2008-12-29Not applicableUs
Rugby Nicotine Polacrilex Gum, Coated Mint Flavorgum, chewing4 mg/1buccalRugby Laboratories2008-12-29Not applicableUs
Rugby Nicotine Polacrilex Gum, Mint Flavorgum, chewing4 mg/1buccalRugby Laboratories2004-07-29Not applicableUs
Rugby Nicotine Polacrilex Gum, Mint Flavorgum, chewing2 mg/1buccalRugby Laboratories2004-07-29Not applicableUs
Rugby Nicotine Polacrilex Gum, Original Flavorgum, chewing4 mg/1buccalRugby Laboratories1999-03-19Not applicableUs
Rugby Nicotine Polacrilex Gum, Original Flavorgum, chewing2 mg/1buccalRugby Laboratories1999-03-15Not applicableUs
Safeway Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs
Safeway Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs
Safeway Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health2007-11-07Not applicableUs
Signature Care Nicotinelozenge2 mg/1oralSafeway2015-10-06Not applicableUs
Signature Care Nicotinelozenge4 mg/1oralSafeway2015-09-28Not applicableUs
Simply Right Nicotinegum, chewing2 mg/1oralSam's West Inc2012-01-26Not applicableUs
Simply Right Nicotinelozenge2 mg/1oralSam's West Inc2012-01-19Not applicableUs
Simply Right Nicotinegum, chewing2 mg/1oralSam's West Inc2012-01-26Not applicableUs
Simply Right Nicotinelozenge2 mg/1oralSam's West Inc2007-09-07Not applicableUs
Simply Right Nicotinegum, chewing4 mg/1oralSam's West Inc2012-01-17Not applicableUs
Simply Right Nicotinegum, chewing4 mg/1oralSam's West Inc2012-01-21Not applicableUs
Simply Right Nicotinelozenge4 mg/1oralSam's West Inc2014-05-05Not applicableUs
Simply Right Nicotinelozenge4 mg/1oralSam's West Inc2012-01-16Not applicableUs
Smart Sense Nicotinelozenge4 mg/1oralKmart Corporation2011-05-10Not applicableUs
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-07-26Not applicableUs
Smart Sense Nicotinegum, chewing2 mg/1oralKmart Corporation2011-02-22Not applicableUs
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-06-06Not applicableUs
Smart Sense Nicotinegum, chewing2 mg/1oralKmart Corporation2011-09-07Not applicableUs
Smart Sense Nicotinegum, chewing4 mg/1oralKmart Corporation2011-03-09Not applicableUs
Smart Sense Nicotinelozenge2 mg/1oralKmart Corporation2011-06-13Not applicableUs
Smart Sense Nicotine Mintgum, chewing2 mg/1oralKmart Corporation2011-06-29Not applicableUs
Smart Sense Nicotine Polacrilexlozenge2 mg/1oralKmart Corporation2011-06-08Not applicableUs
Smart Sense Nicotine Polacrilexlozenge4 mg/1oralKmart Corporation2011-05-09Not applicableUs
Stop Smoking Aidlozenge4 mg/1oralPublix Super Markets Inc2006-04-12Not applicableUs
Stop Smoking Aidgum, chewing4 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs
Stop Smoking Aidlozenge2 mg/1oralPublix Super Markets Inc2006-04-12Not applicableUs
Stop Smoking Aidgum, chewing4 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs
Stop Smoking Aidgum, chewing2 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs
Stop Smoking Aid Nicotinegum, chewing2 mg/1oralPublix Super Markets Inc2005-12-06Not applicableUs
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2005-06-23Not applicableUs
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2005-06-23Not applicableUs
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2005-06-18Not applicableUs
Sunmark Nicotinegum, chewing2 mg/1oralTYA Pharmaceuticals2005-06-23Not applicableUs
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2005-06-18Not applicableUs
Sunmark Nicotinelozenge4 mg/1oralMc Kesson2008-04-30Not applicableUs
Sunmark Nicotinelozenge2 mg/1oralMc Kesson2008-05-07Not applicableUs
Sunmark Nicotinegum, chewing4 mg/1oralMc Kesson2006-12-21Not applicableUs
Sunmark Nicotinegum, chewing2 mg/1oralMc Kesson2006-12-21Not applicableUs
Sunmark Nicotine Transdermal System Step 1patch, extended release21 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs
Sunmark Nicotine Transdermal System Step 2patch, extended release14 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs
Sunmark Nicotine Transdermal System Step 3patch, extended release7 mg/24htopicalNovartis Consumer Health, Inc.2012-01-02Not applicableUs
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2006-10-30Not applicableUs
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2006-12-18Not applicableUs
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2005-04-26Not applicableUs
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2013-02-14Not applicableUs
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2006-12-27Not applicableUs
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2010-01-28Not applicableUs
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2005-04-22Not applicableUs
Topcare Nicotinelozenge2 mg/1oralTopco Associates LLC2013-02-15Not applicableUs
Topcare Nicotinegum, chewing4 mg/1oralTopco Associates LLC2005-04-19Not applicableUs
Topcare Nicotinelozenge4 mg/1oralTopco Associates LLC2013-02-12Not applicableUs
Topcare Nicotinegum, chewing2 mg/1oralTopco Associates LLC2005-04-20Not applicableUs
Topcare Nicotine Polacrilexlozenge2 mg/1oralTopco Associates LLC1998-06-22Not applicableUs
Topcare Nicotine Polacrilexlozenge2 mg/1oralTopco Associates LLC2009-09-03Not applicableUs
Topcare Nicotine Stop Smoking Aidgum, chewing4 mg/1oralTopco Associates LLC2010-01-28Not applicableUs
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2010-03-12Not applicableUs
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2011-02-16Not applicableUs
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2013-08-09Not applicableUs
Up and Up Nicotinelozenge4 mg/1oralTarget Corporation2013-03-13Not applicableUs
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2010-03-11Not applicableUs
Up and Up Nicotinelozenge2 mg/1oralTarget Corporation2013-03-13Not applicableUs
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2011-02-10Not applicableUs
Up and Up Nicotinelozenge4 mg/1oralTarget Corporation2009-07-01Not applicableUs
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2016-03-18Not applicableUs
Up and Up Nicotinelozenge2 mg/1oralTarget Corporation2009-06-16Not applicableUs
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2009-07-09Not applicableUs
Up and Up Nicotinegum, chewing2 mg/1oralTarget Corporation2009-07-01Not applicableUs
Up and Up Nicotinegum, chewing4 mg/1oralTarget Corporation2011-10-06Not applicableUs
Up and Up Nicotine Polacrilexlozenge4 mg/1oralTarget Corporation2011-03-12Not applicableUs
Up and Up Nicotine Polacrilexgum, chewing2 mg/1oralTarget Corporation2011-10-06Not applicableUs
Up and Up Nicotine Polacrilexlozenge2 mg/1oralTarget Corporation2011-02-21Not applicableUs
Up and Up Nicotine Polacrilexgum, chewing4 mg/1oralTarget Corporation2013-08-09Not applicableUs
Zonnic Nicotinegum, chewing4 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs
Zonnic Nicotinegum, chewing4 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2012-06-25Not applicableUs
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs
Zonnic Nicotine Polacrilexgum, chewing2 mg/1oralNiconovum Usa Inc.2013-05-03Not applicableUs
Zonnic Nicotine Polacrilexgum, chewing4 mg/1oralNiconovum Usa Inc.2012-06-27Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nicotine Un1654liquid1 L/LoralNicobrand Ltd1997-07-11Not applicableUs
International Brands
NameCompany
HabitrolNot Available
NicodermNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nicotine polacrilex
ThumbNot applicableDBSALT001599
Categories
UNII6M3C89ZY6R
CAS number54-11-5
WeightAverage: 162.2316
Monoisotopic: 162.115698458
Chemical FormulaC10H14N2
InChI KeyInChIKey=SNICXCGAKADSCV-UHFFFAOYSA-N
InChI
InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
IUPAC Name
3-(1-methylpyrrolidin-2-yl)pyridine
SMILES
CN1CCCC1C1=CN=CC=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassNot Available
Sub ClassNot Available
Direct ParentAlkaloids and derivatives
Alternative Parents
Substituents
  • Nicotine
  • Alkaloid or derivatives
  • Pyrrolidinylpyridine
  • Aralkylamine
  • N-alkylpyrrolidine
  • Pyridine
  • Heteroaromatic compound
  • Pyrrolidine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
PharmacodynamicsNicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.
Mechanism of actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
Related Articles
AbsorptionAbsorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Volume of distribution
  • 2 to 3 L/kg
Protein bindingLess than 5%
Metabolism

Primarily hepatic, cotinine is the primary metabolite.

SubstrateEnzymesProduct
Nicotine
Not Available
N-MethylnicotiniumDetails
Nicotine
Nicotine imineDetails
Nicotine
Not Available
CotinineDetails
Nicotine
Not Available
NornicotineDetails
Nicotine
Nicotine glucuronideDetails
Nicotine
Not Available
NorcotinineDetails
Nicotine
Nicotine-1'-N-oxideDetails
Nicotine
Not Available
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanoneDetails
Nicotine
Not Available
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanolDetails
Nicotine imine
CotinineDetails
Cotinine
Not Available
Cotinine N-oxideDetails
Cotinine
3'-HydroxycotinineDetails
Cotinine
Not Available
NornicotineDetails
Cotinine
Nicotine-1'-N-oxideDetails
Cotinine
Cotinine glucuronideDetails
Route of eliminationAbout 10% of the nicotine absorbed is excreted unchanged in the urine.
Half lifeCotinine has a half life of 15-20 hours, while nicotine has a half life of 1-3 hours
Clearance
  • 1.2 L/min [healthy adult smoker]
ToxicitySymptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Nicotine Action PathwayDrug actionSMP00431
Nicotine Metabolism PathwayDrug metabolismSMP00628
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9748
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.5
P-glycoprotein inhibitor INon-inhibitor0.8998
P-glycoprotein inhibitor IINon-inhibitor0.9368
Renal organic cation transporterInhibitor0.6868
CYP450 2C9 substrateNon-substrate0.7998
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateNon-substrate0.5
CYP450 1A2 substrateNon-inhibitor0.6347
CYP450 2C9 inhibitorNon-inhibitor0.8433
CYP450 2D6 inhibitorNon-inhibitor0.8838
CYP450 2C19 inhibitorNon-inhibitor0.8543
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7589
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9626
BiodegradationNot ready biodegradable0.9478
Rat acute toxicity3.4798 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8851
hERG inhibition (predictor II)Non-inhibitor0.7978
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Novartis consumer health inc
  • Sanofi aventis us llc
  • Aveva drug delivery systems inc
  • Mcneil consumer healthcare
  • Pharmacia and upjohn co
  • Pfizer inc
  • Glaxosmithkline
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Perrigo co
  • Perrigo r and d co
  • Watson laboratories inc
  • Glaxosmithkline consumer healthcare
Packagers
Dosage forms
FormRouteStrength
Patch, extended releasetransdermal14 mg/1
Patch, extended releasetransdermal21 mg/1
Patch, extended releasetransdermal7 mg/1
Gum, chewingoral2 mg/1
Gum, chewingoral4 mg/1
Lozengeoral2 mg/1
Lozengeoral4 mg/1
Patch, extended releasetransdermal21 mg/24h
Patch, extended releasetransdermal14 mg/24h
Patch, extended releasetransdermal7 mg/24h
Patch, extended releasetopical21 mg/1
Patch, extended releasetopical7 mg/1
Patchtransdermal114 mg
Patchtransdermal36 mg
Patchtransdermal78 mg
Gumoral2 mg
Patchtransdermal25 mg
Gumoral4 mg
Patchtransdermal14 mg/24h
Patchtransdermal21 mg/24h
Patchtransdermal7 mg/24h
Kittransdermal
Kit
Liquidoral1 L/L
Inhalantrespiratory (inhalation)4 mg/1
Spray, meterednasal10 mg/mL
Gum, chewingbuccal2 mg/1
Gum, chewingbuccal4 mg/1
Patch, extended releasetopical21 mg/24h
Patch, extended releasetopical14 mg/24h
Patch, extended releasetopical7 mg/24h
Prices
Unit descriptionCostUnit
Nicotrol 168 10 mg Inhalant Inhaler223.5USD inhaler
Nicotine 30 21 mg/24hr Patches Box206.52USD box
Nicotine 30 14 mg/24hr Patches Box196.27USD box
Nicotrol NS 10 mg/ml Solution 10ml Bottle55.88USD bottle
Nicotine polacrilex powder11.25USD g
Nicotrol ns 10 mg/ml spray5.37USD ml
Nicoderm cq 21 mg/24hr patch4.08USD patch
Nicoderm cq 14 mg/24hr patch3.52USD patch
Nicoderm cq 7 mg/24hr patch3.52USD patch
Nicotine 11 mg/24hr patch3.14USD patch
Nicotine 22 mg/24hr patch3.14USD patch
Nicotine transdermal system1.83USD each
Nicotrol cartridge inhaler1.28USD each
Commit 2 mg lozenge0.55USD lozenge
Commit 4 mg lozenge0.55USD lozenge
Nicorette 4 mg chewing gum0.52USD each
Nicorette 2 mg chewing gum0.45USD each
Thrive nicotine 2 mg gum0.42USD each
Thrive nicotine 4 mg gum0.42USD each
CVS Pharmacy nicotine 4 mg chewing gum0.38USD each
CVS Pharmacy nicotine 2 mg chewing gum0.34USD each
Nicotine 4 mg chewing gum0.3USD each
Nicotine 2 mg chewing gum0.25USD each
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA1333051 No1994-11-152011-11-15Canada
US5501236 No1993-06-082010-06-08Us
US5656255 No1994-08-122014-08-12Us
US8075911 No2001-05-222021-05-22Us
US8323683 No2008-04-302028-04-30Us
US8501164 No2009-06-142029-06-14Us
US8663680 No2000-02-132020-02-13Us
US8940772 No2009-04-302029-04-30Us
US8999379 No2000-02-132020-02-13Us
US9205059 No1999-12-152019-12-15Us
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point-79 °CPhysProp
boiling point247 °CPhysProp
water solubility1E+006 mg/LSEIDELL,A (1941)
logP1.17HANSCH,C ET AL. (1995)
logS0.79ADME Research, USCD
Caco2 permeability-4.71ADME Research, USCD
pKa3.1TOMLIN,C (1997); pKa1
Predicted Properties
PropertyValueSource
Water Solubility93.3 mg/mLALOGPS
logP0.87ALOGPS
logP1.16ChemAxon
logS-0.24ALOGPS
pKa (Strongest Basic)8.86ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity49.66 m3·mol-1ChemAxon
Polarizability18.62 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
SpectraNot Available
References
Synthesis Reference

Charles G. Chavdarian, Edward B. Sanders, “Process for the preparation of optically active nicotine analogs.” U.S. Patent US4321387, issued September, 1959.

US4321387
General References
  1. Nolley EP, Kelley BM: Adolescent reward system perseveration due to nicotine: studies with methylphenidate. Neurotoxicol Teratol. 2007 Jan-Feb;29(1):47-56. Epub 2006 Oct 4. [PubMed:17129706 ]
  2. de Leon J, Tracy J, McCann E, McGrory A, Diaz FJ: Schizophrenia and tobacco smoking: a replication study in another US psychiatric hospital. Schizophr Res. 2002 Jul 1;56(1-2):55-65. [PubMed:12084420 ]
  3. de Leon J, Dadvand M, Canuso C, White AO, Stanilla JK, Simpson GM: Schizophrenia and smoking: an epidemiological survey in a state hospital. Am J Psychiatry. 1995 Mar;152(3):453-5. [PubMed:7864277 ]
  4. Aguilar MC, Gurpegui M, Diaz FJ, de Leon J: Nicotine dependence and symptoms in schizophrenia: naturalistic study of complex interactions. Br J Psychiatry. 2005 Mar;186:215-21. [PubMed:15738502 ]
External Links
ATC CodesN07BA01
AHFS Codes
  • 12:92.00
  • 24:06.92
  • 88:08.00
  • 92:02.00*
PDB Entries
FDA labelDownload (11.2 MB)
MSDSDownload (77.6 KB)
Interactions
Drug Interactions
Drug
AdenosineNicotine may increase the atrioventricular blocking (AV block) activities of Adenosine.
AmiodaroneThe metabolism of Nicotine can be decreased when combined with Amiodarone.
AmobarbitalThe metabolism of Nicotine can be increased when combined with Amobarbital.
CimetidineThe serum concentration of Nicotine can be increased when it is combined with Cimetidine.
Cyproterone acetateThe serum concentration of Nicotine can be decreased when it is combined with Cyproterone acetate.
DisulfiramThe metabolism of Nicotine can be decreased when combined with Disulfiram.
Hydroxyprogesterone caproateThe metabolism of Nicotine can be increased when combined with Hydroxyprogesterone caproate.
IsoniazidThe metabolism of Nicotine can be decreased when combined with Isoniazid.
KetoconazoleThe metabolism of Nicotine can be decreased when combined with Ketoconazole.
LetrozoleThe metabolism of Nicotine can be decreased when combined with Letrozole.
MethoxsalenThe metabolism of Nicotine can be decreased when combined with Methoxsalen.
PentobarbitalThe metabolism of Nicotine can be increased when combined with Pentobarbital.
PhenobarbitalThe metabolism of Nicotine can be increased when combined with Phenobarbital.
RifampicinThe metabolism of Nicotine can be increased when combined with Rifampicin.
SecobarbitalThe metabolism of Nicotine can be increased when combined with Secobarbital.
TranylcypromineThe metabolism of Nicotine can be decreased when combined with Tranylcypromine.
VareniclineThe risk or severity of adverse effects can be increased when Varenicline is combined with Nicotine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Gene Name:
CHRNA4
Uniprot ID:
P43681
Molecular Weight:
69956.47 Da
References
  1. Espeseth T, Endestad T, Rootwelt H, Reinvang I: Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience. 2007 Jul 29;147(4):974-85. Epub 2007 Jun 27. [PubMed:17590520 ]
  2. Winterer G, Musso F, Konrad A, Vucurevic G, Stoeter P, Sander T, Gallinat J: Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum Mol Genet. 2007 Sep 15;16(18):2165-74. Epub 2007 Jul 5. [PubMed:17613539 ]
  3. Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):596-604. [PubMed:17226798 ]
  4. Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J: Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7. Epub 2006 Dec 4. [PubMed:17146052 ]
  5. De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. [PubMed:16636791 ]
  6. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  7. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  8. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  9. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Toxic substance binding
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Gene Name:
CHRNA7
Uniprot ID:
P36544
Molecular Weight:
56448.925 Da
References
  1. Mexal S, Jenkins PM, Lautner MA, Iacob E, Crouch EL, Stitzel JA: alpha7 nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion. J Biol Chem. 2007 May 4;282(18):13220-7. Epub 2007 Mar 14. [PubMed:17360707 ]
  2. Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R: Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006 Jun;63(6):630-8. [PubMed:16754836 ]
  3. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  4. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  5. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  6. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Gene Name:
CHRNB2
Uniprot ID:
P17787
Molecular Weight:
57018.575 Da
References
  1. Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS: Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):596-604. [PubMed:17226798 ]
  2. De Luca V, Voineskos S, Wong G, Kennedy JL: Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia. Exp Brain Res. 2006 Sep;174(2):292-6. Epub 2006 Apr 25. [PubMed:16636791 ]
  3. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  4. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  5. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  6. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Drug binding
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNA2
Uniprot ID:
Q15822
Molecular Weight:
59764.82 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
  5. Sullivan PF, Neale BM, van den Oord E, Miles MF, Neale MC, Bulik CM, Joyce PR, Straub RE, Kendler KS: Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics. Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):23-36. [PubMed:15048644 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNA3
Uniprot ID:
P32297
Molecular Weight:
57479.54 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNA5
Uniprot ID:
P30532
Molecular Weight:
53053.965 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Acetylcholine-activated cation-selective channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNA6
Uniprot ID:
Q15825
Molecular Weight:
56897.745 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Calcium channel activity
Specific Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the ...
Gene Name:
CHRNA9
Uniprot ID:
Q9UGM1
Molecular Weight:
54806.63 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Receptor binding
Specific Function:
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes t...
Gene Name:
CHRNA10
Uniprot ID:
Q9GZZ6
Molecular Weight:
49704.295 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Drug binding
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNB3
Uniprot ID:
Q05901
Molecular Weight:
52728.215 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Ligand-gated ion channel activity
Specific Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Gene Name:
CHRNB4
Uniprot ID:
P30926
Molecular Weight:
56378.985 Da
References
  1. Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22. [PubMed:19560048 ]
  2. Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202. [PubMed:11006350 ]
  3. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16. [PubMed:20400469 ]
  4. Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. [PubMed:20081230 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Barbieri RL, Gochberg J, Ryan KJ: Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. J Clin Invest. 1986 Jun;77(6):1727-33. [PubMed:3711333 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Choline o-acetyltransferase activity
Specific Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Gene Name:
CHAT
Uniprot ID:
P28329
Molecular Weight:
82535.025 Da
References
  1. FAHMY AR, RYMAN BE, WALSH EO: The inhibition of choline acetylase by nicotine. J Pharm Pharmacol. 1954 Sep;6(9):607-9. [PubMed:13192619 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
Gene Name:
CYP2A13
Uniprot ID:
Q16696
Molecular Weight:
56687.095 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Serotonin binding
Specific Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Gene Name:
MAOA
Uniprot ID:
P21397
Molecular Weight:
59681.27 Da
References
  1. Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2012 Jan;21(1):39-43. doi: 10.1136/tc.2010.040287. Epub 2011 Jun 2. [PubMed:21636610 ]
  2. Leroy C, Bragulat V, Berlin I, Gregoire MC, Bottlaender M, Roumenov D, Dolle F, Bourgeois S, Penttila J, Artiges E, Martinot JL, Trichard C: Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone. J Clin Psychopharmacol. 2009 Feb;29(1):86-8. doi: 10.1097/JCP.0b013e31819e98f. [PubMed:19142115 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Primary amine oxidase activity
Specific Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Gene Name:
MAOB
Uniprot ID:
P27338
Molecular Weight:
58762.475 Da
References
  1. Lewis AJ, Truman P, Hosking MR, Miller JH: Monoamine oxidase inhibitory activity in tobacco smoke varies with tobacco type. Tob Control. 2012 Jan;21(1):39-43. doi: 10.1136/tc.2010.040287. Epub 2011 Jun 2. [PubMed:21636610 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
  3. Okuda M, Urakami Y, Saito H, Inui K: Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. [PubMed:10082798 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
  2. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. [PubMed:9655880 ]
  3. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Toxin transporter activity
Specific Function:
Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
Gene Name:
SLC22A3
Uniprot ID:
O75751
Molecular Weight:
61279.485 Da
References
  1. Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998 Jun 26;273(26):15971-9. [PubMed:9632645 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. [PubMed:9618255 ]
  2. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. [PubMed:10525100 ]
  3. Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. [PubMed:10454528 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Molecular Weight:
62154.48 Da
References
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
  2. Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. [PubMed:10825452 ]
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Drug created on June 13, 2005 07:24 / Updated on May 26, 2016 02:10